[Personalized approach in the diagnostics and treatment of symptomatic epilepsy with déjà vu seizures].

The phenomenon of déjà vu (DV) is of interest, occurring in 97% of healthy individuals, while DV can be a manifestation of a number of pathologies, such as Charles Bonnet syndrome, depression, schizophrenia, or temporal lobe epilepsy. Most cases of DV type epiphenomena are associated with hippocampal sclerosis, while up to 90% of patients with mesial temporal sclerosis are drug resistant. Despite the success of pharmacotherapy, the frequency of «uncontrolled¼ epilepsy in industrialized countries that adhere to modern standards of treatment is from 30 to 40%, and this percentage is higher among patients with symptomatic and cryptogenic forms than among patients with idiopathic epilepsy (respectively: 40% and 26%). In turn, when studying the DV phenomenon and choosing a therapy strategy, it is necessary to establish its origin, determine its clinical significance (whether it is initially pathological or not), and the need for treatment. During the analysis of exome data, a search was made for substitutions in genes associated with arteriovenous malformations, both with autosomal dominant and autosomal recessive types of inheritance. The genes KRIT1, RASA1, IL6, FAM58A, GLML, EPHB4, CCM2, and ELMO2 were analyzed especially carefully. The analysis of genetic data is of great importance in the aspect of preventing cerebrovascular accidents, at the same time, in order to obtain reliable and significant results, in addition to time and financial costs, examination of relatives is also required. Meanwhile, this fact does not mean that every patient needs to conduct a genetic study. The paper presents detailed instructions for supplementing anamnestic information, as well as the results of personalized instrumental and laboratory diagnostics, which made it possible to carry out timely correction of therapy and achieve a prolonged positive effect.

[Sleep disorders in nurses working during the COVID-19 pandemic]. / Rasstroistva sna u meditsinskikh sester, rabotayushchikh v period pandemii COVID-19.

The reorganization of treatment facilities during the COVID-19 pandemic has altered the working conditions of large numbers of the health workers (HW) worldwide. The implementation of professional activities in such realities has led to an increased risk of developing a number of psychological disorders, including insomnia. The percentage of insomnia in HW has increased significantly. The nurses were the most vulnerable, because they are women and they work in an understaffed environment. The influence of shift work and stress conditions on the risk of insomnia, methods of prevention and treatment of this disorder are thoroughly examined in the article.

[Influence of graduated physical exercises combined with soft tissue manual therapy on the psychoemotional status and cognitive functions of patients].

The results of treatment patients with psychovegetative syndrome, including graduated physical exercises combined with soft tissue manual therapy, are represented. Course of medical correction assisted in elimination of hypersympathicotonia, regress of worried disturbances, improvement of memory, physical efficiency, activity and mood. Efficiency of treatment is higher in patients with insignificant decrease in physical efficiency.

[Effects of electromagnetic fields on tonicity of cerebral vessels and arterial pressure].

Investigations performed by the authors show that normalization of the mechanisms of vegetative regulation of arterial pressure and cerebral vessels tonicity in young patients with sympathico-tonic vegetative dystonia can be achieved by combined use of constant magnetic field (magnetic induction 60 mTl, penetration 10 mm, area 1.5 cm2) and monochromatic electromagnetic wave (length 0.47 mcm, frequency 6 x 10(14) Hz, penetration 1.5 mm and light spot 7 mm) which are directed to a biologically active point C7 shen-men from both sides simultaneously for 3 min, at 11 a.m. to 13 p.m. once a day, for 10 days.

[Color-physiopuncture corrections of autonomic disorders]. / Tsvetofiziopunkturnaia korrektsiia vegetativnykh narushenii.

Investigations have shown that electromagnetic waves of color band used for physiopuncture correction of functional-dynamic condition of channel-meridional system of the body in young patients with vegetovascular asthenia of a hypertensive type lead to a regress of the clinical symptoms, normalization of arterial pressure, correction of cerebral hemodynamic disorders, recovery of normal bioelectric activity of the brain.

[Changes in the autonomic status in vegetovascular dystonia syndrome during exposure to permanent magnetic field ]. / Izmenenie vegetativnogo statusa pri sindrome vegetososudistoi distonii pod vliianiem postoiannogo magnitnogo polia.

Permanent magnetic field was applied by placing two magnetic discs (induction 60 mT) in the projection of great arteries on both sides symmetrically. The treatment was given to hypertensive patients with vegetovascular asthenia. A course of such magnetic treatment affects pathogenetic mechanisms of vegetative disorders due to the ability of permanent magnetic field to restore vegetative homeostasis, normalize sympathicotony and vegetative regulation.