Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies.

In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.

[Extracorporeal treatments for some autoimmune eye diseases].

Fifty-three patients with eye diseases caused by autoimmune disorders received complex treatment involving extracorporeal techniques, such as hemosorption, plasmapheresis, and double cascade plasma filtration in combination with pulse therapy. Clinical, laboratory, morphometric, and biochemical studies show the efficacy of hemosorption in relieving acute manifestations of an inflammatory process and the stabilizing action of these methods on ocular epithelial tissue, immunological activity, and systemic manifestations of the underlying disease.

[Non-specific hemosorption: current state and prospects].

Results of experimental and clinical evaluation of the method of nonspecific hemosorption obtained in the Laboratory of Clinical Immunology and Republican Centre for Application of Extracorporeal Therapies, Research Institute of Physical and Clinical Medicine, since 1985 are presented. Analysis of these and literature data on the efficiency of hemosorption in non-toxicological practice allows for the conclusion of socio-medical and economic feasibility of more extensive application of the method.