RESUMO
The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer was published in 2022. It was therefore decided, by both the ESMO and the Indian Society of Medical and Paediatric Oncology (ISMPO), to convene a virtual meeting in July 2022 to adapt the ESMO 2022 guidelines to take into account the variations in the management of endometrial cancer in Asia. These guidelines represent the consensus opinion of a panel of Asian experts representing the oncological societies of China (CSCO), India (ISMPO), Indonesia (ISHMO), Japan (JSMO), Korea (KSMO), Malaysia (MOS), the Philippines (PSMO), Singapore (SSO), Taiwan (TOS) and Thailand (TSCO). Voting was based on scientific evidence and was conducted independently of the current treatment practices and treatment access constraints in the different Asian countries, which were discussed when appropriate. The aim of this guideline manuscript is to provide guidance for the optimisation and harmonisation of the management of patients with endometrial cancer across the different regions of Asia, drawing on the evidence provided by Western and Asian trials whilst respecting the variations in clinical presentation, diagnostic practices including molecular profiling and disparities in access to therapeutic options, including drug approvals and reimbursement strategies.
Assuntos
Neoplasias do Endométrio , Sociedades Médicas , Criança , Feminino , Humanos , Ásia , Neoplasias do Endométrio/diagnóstico , OncologiaAssuntos
Neoplasias da Mama/terapia , Conferências de Consenso como Assunto , Oncologia/normas , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Biópsia com Agulha de Grande Calibre , Mama/diagnóstico por imagem , Mama/patologia , Mama/cirurgia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Quimiorradioterapia Adjuvante/métodos , Quimiorradioterapia Adjuvante/normas , Ensaios Clínicos como Assunto , Europa (Continente) , Medicina Baseada em Evidências/métodos , Medicina Baseada em Evidências/normas , Feminino , Humanos , Medicina Integrativa/métodos , Medicina Integrativa/normas , Mastectomia/métodos , Mastectomia/normas , Oncologia/métodos , Terapia Neoadjuvante/métodos , Terapia Neoadjuvante/normas , Estadiamento de Neoplasias , Sociedades Médicas/normas , Resultado do TratamentoRESUMO
OBJECTIVE: To update our earlier systematic reviews which evaluated all published randomized controlled trials (RCTs) evaluating pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (OA). Surgical therapies were not evaluated. DESIGN: RCTs published between March 2008 and December 2015 were added to the previous systematic reviews. RESULTS: A total of 95 RCTs evaluating various pharmacological and non-pharmacological therapies in hand OA were analyzed in this update. Generally, the methodological quality of these RCTs has improved since the last update, with more studies describing their methods for randomization, blinding, and allocation concealment. However, RCTs continue to be weakened by a lack of consistent case definition and a lack of standardized outcome assessments specific to hand OA. The number and location of evaluated hand joints continues to be underreported, and only 25% of RCTs adequately described the method used to ensure allocation concealment. These remain major weaknesses of published RCTs. A meta-analysis could not be performed because of marked study heterogeneity, insufficient statistical data available in the published RCTs, and a small number of identical comparators. CONCLUSION: Hand OA is a complex area in which to study the efficacy of therapies. There has been an improvement in the overall design and conduct of RCTs, however, additional large RCTs with a more robust methodological approach specific to hand OA are needed in order to make clinically relevant conclusions about the efficacy of the diverse treatment options available.
Assuntos
Articulação da Mão , Osteoartrite/terapia , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Projetos de PesquisaRESUMO
A validated in vitro model of cartilage damage and published data were used showing that this model measures the chondroprotective and antiinflammatory effects of different antiarthritic drugs. In this report, this model was used to evaluate the effects of a new antiarthritic Ayurvedic formulation containing Zingiber officinale root, Tinospora cordifolia stem, Phyllanthus emblica fruit and oleoresin of Boswellia serrata. Glucosamine sulphate was used as a positive control in the study. Aqueous extracts of each drug were tested on explant cultures of knee cartilage obtained from osteoarthritis patients undergoing knee replacement surgery. The new formulation caused a sustained and statistically significant inhibition in the release of glycosaminoglycans and aggrecan by cartilage explants from these patients. This formulation also induced a transient antiinflammatory effect as measured by a reduction in the levels of nitric oxide released by explants. Furthermore, the data strongly suggest that oleoresin of B. serrata plays a crucial role in the chondroprotective and antiinflammatory activity of this formulation. In summary, this report provides the first, direct, in vitro biochemical evidence of anti-arthritic activity a new Ayurvedic formulation. This formulation significantly reduced damage of articular knee cartilage from chronic osteoarthritis patients.
Assuntos
Anti-Inflamatórios/farmacologia , Boswellia/química , Cartilagem Articular/efeitos dos fármacos , Articulação do Joelho/efeitos dos fármacos , Preparações de Plantas/farmacologia , Idoso , Agrecanas/metabolismo , Glicosaminoglicanos/metabolismo , Humanos , Técnicas In Vitro , Ayurveda , Pessoa de Meia-Idade , Óxido Nítrico/metabolismo , Osteoartrite/tratamento farmacológico , Extratos Vegetais/farmacologiaRESUMO
Natural killer (NK) activity and natural killer cytotoxic factors (NKCF) were found to be depressed in large granular lymphocytes (LGL) from the peripheral blood and lymph node lymphocytes (LNL) from untreated non-Hodgkin's lymphoma (NHL) patients. The LGL number was also reduced in NHL patients as compared to the normal subjects. The depression in all the activities mentioned above showed a correlation with the clinical status of the patients. Exogenous interferon-alpha (IFN-alpha) treatment of the effector cells could augment the NK activity to a comparable extent in normal as well as patient's LNL. The results indicate that the production of interferon may be affected in cases of NHL and therefore it would be worthwhile to test the tolerance and efficacy of IFN-alpha in these patients.
Assuntos
Citotoxicidade Imunológica , Células Matadoras Naturais/imunologia , Linfoma não Hodgkin/imunologia , Adulto , Citotoxicidade Imunológica/efeitos dos fármacos , Humanos , Interferon Tipo I/farmacologia , Células Matadoras Naturais/efeitos dos fármacos , Linfonodos/citologia , Linfonodos/imunologia , Linfócitos/efeitos dos fármacos , Linfócitos/imunologia , Células Tumorais CultivadasAssuntos
Crise Blástica/tratamento farmacológico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Adolescente , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Criança , Feminino , Hepatomegalia , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , EsplenomegaliaRESUMO
We observed 50 patients receiving high-dose cisplatin-based chemotherapy in a prospective, randomized double-blind trial. One group received metoclopramide (MCP) alone (total dose, 6 mg/kg), whereas the other group was given dexamethasone (DMS) (total dose, 60 mg) in addition to MCP. The patient characteristics of the two groups were comparable, confirming satisfactory randomization. Multivariate regression analysis failed to show any statistical significance in the antiemetic response between the two treatment groups. However, female patients receiving Adriamycin (Adria Laboratories, Columbus, OH) concurrently and obese persons exhibited more vomiting. The overall antiemetic response rate was 66%. Because the side effects were minimal, a higher dose of MCP is expected to improve emetic control without increasing toxicity. The use of a 36-hour assessment period in our study gave more meaningful data. An exponential increase in the dose of MCP is probably required, with respect to weight, to obtain the same antiemetic efficacy.
Assuntos
Cisplatino/efeitos adversos , Dexametasona/uso terapêutico , Metoclopramida/uso terapêutico , Neoplasias/tratamento farmacológico , Vômito/prevenção & controle , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Cisplatino/administração & dosagem , Cisplatino/uso terapêutico , Ensaios Clínicos como Assunto , Método Duplo-Cego , Doxorrubicina/administração & dosagem , Quimioterapia Combinada , Feminino , Humanos , Masculino , Estudos Prospectivos , Distribuição Aleatória , Vômito/induzido quimicamenteRESUMO
One hundred fifty patients with nasopharyngeal carcinoma were treated at the Tata Memorial Hospital from January 1980 to December 1984. Lymphoepithelioma was the most common histologic subtype. Advanced disease in stages III and IV was seen in 22.66% and 72% of the patients, respectively. Complete remission was obtained in 80 of 120 patients (66.66%) with radiation alone and in 19 of 30 patients (63.3%) who received preradiation chemotherapy and radiation. Age, sex, and histology did not influence the rate of complete remission. The N0-1 nodal status group had a significantly better response of 81% and 36% survival, as compared with the N2-3 group with a 55% response and 20% survival. Only 30 of those who received radiation alone and 10 of those who received preradiation chemotherapy are disease-free for a median period of 24 months. Twenty-six relapses have occurred within a median period of 12 months. The 5-year actuarial disease-free survival is 13%. This indicates the need for an early diagnosis and combined aggressive treatment to improve survival.
Assuntos
Carcinoma de Células Escamosas/radioterapia , Neoplasias Nasofaríngeas/radioterapia , Adolescente , Adulto , Idoso , Carcinoma de Células Escamosas/patologia , Criança , Terapia Combinada , Interpretação Estatística de Dados , Humanos , Índia , Pessoa de Meia-Idade , Neoplasias Nasofaríngeas/patologia , Metástase Neoplásica , Recidiva Local de Neoplasia , Radioterapia de Alta Energia/métodos , Indução de RemissãoAssuntos
Neoplasias Encefálicas/prevenção & controle , Leucemia-Linfoma Linfoblástico de Células Precursoras/prevenção & controle , Neoplasias da Medula Espinal/prevenção & controle , Adolescente , Encéfalo/efeitos da radiação , Neoplasias Encefálicas/radioterapia , Criança , Pré-Escolar , Feminino , Humanos , Injeções Espinhais , Masculino , Metotrexato/administração & dosagem , Metotrexato/uso terapêutico , Leucemia-Linfoma Linfoblástico de Células Precursoras/radioterapia , Recidiva , Estudos Retrospectivos , Neoplasias da Medula Espinal/radioterapiaAssuntos
HDL-Colesterol/isolamento & purificação , LDL-Colesterol/isolamento & purificação , VLDL-Colesterol/isolamento & purificação , HDL-Colesterol/sangue , LDL-Colesterol/sangue , VLDL-Colesterol/sangue , Cromatografia em Gel , Eletroforese em Gel de Poliacrilamida , Feminino , Humanos , MasculinoRESUMO
We report a patient with Poland's syndrome who developed acute lymphoblastic leukemia (ALL) at 28 years of age. This is the first time that such an association has been reported from outside the United States or in an adult. The relevant literature is reviewed.
Assuntos
Leucemia Linfoide/patologia , Síndrome de Poland/patologia , Sindactilia/patologia , Adulto , Humanos , Leucemia Linfoide/diagnóstico , Masculino , Síndrome de Poland/diagnósticoAssuntos
Mitocôndrias Hepáticas/efeitos dos fármacos , Tri-Iodotironina/farmacologia , Animais , Fracionamento Celular , Centrifugação com Gradiente de Concentração , Eletroforese , Fígado/citologia , Masculino , Mitocôndrias Hepáticas/análise , Ratos , Ratos Endogâmicos , Tireoidectomia , Fatores de TempoRESUMO
1. A water-soluble lipoprotein was isolated and purified from osmotically shocked preparations of rat liver mitochondria by using a technique of Sephadex-sandwich disc electrophoresis. 2. The purified lipoprotein migrates as a distinct sharp zone in high-resolution electrophoretic systems, indicating high degree of purity. 3. The lipoprotein resembles mitochondrial membranes with respect to lipid composition and lipid/protein ratio. 4. The lipoprotein and its apoprotein fraction obtained by delipidization at -18 degrees C to -20 degrees C have common properties with respect to their fluorescence spectra, instability to storage and electrophoretic mobility. 5. The purified lipoprotein has an excitation maximum at 325nm and a fluorescence maximum at 418nm. 6. Storage at 4 degrees C for 4 days or repeated freezing and thawing results in 15-30% decrease in electrophoretic mobility. 7. The patterns of incorporation in vitro of [1-(14)C]leucine into proteins of the soluble lipoprotein and of mitochondrial membrane of isolated rat liver mitochondria suggest a probable precursor role for the apoprotein in the formation of mitochondrial membrane protein. 8. Lipoprotein preparations isolated from mitochondrial fractions of rat kidney, brain and heart and of chicken and mouse liver resemble closely that obtained from rat liver mitochondria, suggesting that the soluble lipoprotein could be a distinct entity of mitochondrial origin.