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Following cardiovascular disease, cancer is the second leading cause of death in most affluent countries. The 13.3 million new cases of cancer in 2010 were predicted to cost US$ 290 billion, but the total costs were expected to increases to US$ 458 billion in the year 2030 on basis of World Economic Forum in 2011. More than half of all cancer cases and deaths worldwide are consider being preventable. From its inception, the disease control priorities series has focused attention on delivering efficacious health interventions that can result in dramatic reductions in mortality and disability at relatively modest cost. The approach has been multidisciplinary, and the recommendations have been evidence-based, scalable, and adaptable in multiple settings. Better and more equitable health care is the shared responsibility of governments and international agencies, public and private sectors, and societies and individuals, and all of these partners have been involved in the development of the series. Functional foods are foods and food components that supply health benefits beyond basic nutrition. It's-believed these functional foods do more than simply provide nutrients because they help to maintaining health and thereby reducing the risk of disease. There are some reported evidences showing association between functional foods and cancer. For example, S-ally cysteine of garlic and lycopene from tomatoes in combination form suppressed the development of chemically induced gastric cancer by modulation of apoptosis-associated proteins (reduced Bcl-2/Bax ratio and up-regulation of Bim and caspases 8 and 3) at considerably lower intakes than when these substances were given in isolation. Similarly, vitamin D3 with genistein in combination form precipitated a growth inhibition of prostate cancer cells at much lower concentration than when these substances were provided individually. There are very few studies conducted worldwide to see the effects of functional foods on health or cancer or related states. This review, presents the complex patterns of cancer incidence and death around the world and evidence on effective and cost-effective ways to control cancers. The evaluation of cancer will indicate where cancer treatment is ineffective and wasteful, and offer alternative cancer care packages that are cost-effective and suited to low-resource settings. In the present paper, cancer prevention by functional foods is reviewed and the possible mechanisms of action are described.
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The amount of data in electronic and real world is constantly on the rise. Therefore, extracting useful knowledge from the total available data is very important and time consuming task. Data mining has various techniques for extracting valuable information or knowledge from data. These techniques are applicable for all data that are collected inall fields of science. Several research investigations are published about applications of data mining in various fields of sciences such as defense, banking, insurances, education, telecommunications, medicine and etc. This investigation attempts to provide a comprehensive survey about applications of data mining techniques in breast cancer diagnosis, treatment & prognosis till now. Further, the main challenges in these area is presented in this investigation. Since several research studies currently are going on in this issues, therefore, it is necessary to have a complete survey about all researches which are completed up to now, along with the results of those studies and important challenges which are currently exist in this area for helping young researchers and presenting to them the main problems that are still exist in this area.
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It is shown that diabetes can change hematological parameters and some microalgae, i.e. Spirulina platensis, could improve hematological parameters in non-diabetic rats. The purpose of this study was to investigate the effects of Spirulina platensis (SPM) microalgae on hematological parameters in diabetic rats induced by Streptozotocin. Rats, 2.5 males old, were grouped into two sections including healthy and diabetic and received orally 15 and 30 mg/kg body weight SPM for 5 weeks. Control rats received 0.3 ml of distilled water. The experimental groups were as follows; (SH15), healthy rats fed SPM (SH30) 30 mg/kg, diabetic rats fed 15 mg/kg SPM (SD15), diabetic rats fed SPM (SD30) 15 mg/kg, and diabetic control (DC). At the end of the test, blood samples were collected to measure red blood cells, white blood cells, mean corpuscular hemoglobin concentration (MCHC), mean cell volume (MCV) and packed cell volume (PCV). The induction of diabetes decreased RBC, MCHC, PCV, MCV and WBC (P < 0.05), but the oral supplement of SPM (30 mg/kg body weight) could improve RBC, WBC, MCHC, PCV and MCV in rats (P < 0.05). The oral complement of SPM, at high levels, seems to be an effective strategy against the negative effects of diabetes on hematological parameters.
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INTRODUCTION: Peppermint is an efficient medicinal plant for the treatment of diseases, and it also can be used to produce raw materials in the pharmaceutical industry. The purpose of the current study was to evaluate the effects of various levels of peppermint alcoholic extract on body-weight gain and blood biochemical parameters in adult male Wistar rats. METHODS: This experiment was conducted using a completely randomized design (CRD). Fifty adult, healthy, male Wistar rats (ages of 2.5-3 months; weights of 190-210 g) were allocated randomly into five groups. T1 was the control group in which the rats received 0.3 ml of distilled water). Groups T2, T3, T4, and T5 received 75, 150, 300, and 600 mg/kg of peppermint extract, respectively. The rats received daily pretreatment by oral gavages for 21 days. We recorded body weights at the beginning and at the end of the study to determine the changes in the body weights. Blood samples were collected for the measurement of glucose, cholesterol, triglycerides, HDL, LDL, albumin, globulin, and total protein. Statistical analysis of the data was done by SAS software. The data statistically analyzed using one-way analysis of variance (ANOVA), which was conducted through Dennett's multiple comparison post-test. RESULTS: The results indicated that the rats treated with peppermint gained more weight (p < 0.05) and also decreased the serum concentrations of triglycerides, total cholesterol, LDL, and glucose in T3, T4 and T5 than the other groups (p < 0.05). CONCLUSION: Peppermint extract had a positive effect on body-weight gain and some blood parameters in adult male Wistar rats. The findings showed that peppermint is a crucial substance at high temperature, and future research should be focused on determining the details of the mechanisms involved in producing the observed effects of peppermint extract.
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OBJECTIVE: To determine the values of amniotic fluid (AF) progesterone and biochemical constituents and its associated placenta traits in Iranian crossbred ewes (Arkhar-Merino×Ghezel). METHODS: Sixty ewes (2-5 years old, weighing 40-50 kg) were treated with controlled internal drug release induced 30 mg progesterone for 14 d and were injected with 400 IU pregnant mare serum gonadotropin at the time of CIDR withdrawal. After the detection of estrus, ewes were hand-mated. After expelling of each fetus accompanied by fetal membranes, 10 mL AF was taken from fetal sac for spectrophotometer methods (glucose, urea, creatinine, total protein, cholesterol, triglycerides, calcium and phosphorus) and radioimmunoassay (progesterone) analysis. RESULTS: Results indicated that there were highly positive correlations between placental efficiency and cotyledon density (r=0.764, P<0.01), and negative correlation between placental weight (PW) with the total volume amniotic fluid (TVAF) (r=-0.872, P<0.01). A positive relationship was calculated between TVAF with total protein and creatinine (r=0.418, P<0.01 and r=0.639, P<0.05, respectively). However, the correlation between the glucose and PW, cotyledon length and calcium were significantly positive (r=0.704 and r=0.712; P<0.01, respectively). The findings of this study demonstrated that there were no relationships between progesterone concentrations and placental traits (P>0.01), except for PW (r=0.665). CONCLUSIONS: In conclusion, the significant correlation between the AF biochemical and progesterone with placental traits for the above-mentioned metabolites suggests that metabolic changes in AF levels will reflect the condition in the AF.
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OBJECTIVE: To investigate the effect of the presence or absence of corpus luteum on hormonal composition of follicular fluid (FF) from different sized follicles and their relationship to serum concentrations in dairy cows. METHODS: Ovaries were collected from 30 clinically healthy adult female cows (Holstein Friesian) 4-7 years of age with clinically normal reproductive tracts after slaughtering. Blood samples were collected from the jugular vein before slaughter from each cow. The stage of the cycle in the cows was determined postmortem. The ovaries collected from per cow were classified with corpus luteum (CL(+)) and without corpus luteum (CL(-)). FF was aspirated from small (3-5 mm), medium (6-9 mm), and large (10-20 mm) follicles in CL(+) and CL(-) ovaries. Serum and FF samples were analyzed for estradiol-17ß, progesterone, testosterone, T3 and T4 concentrations. RESULTS: Results demonstrated that the FF concentrations of estradiol-17ß, progesterone and testosterone in different sized follicles categories (small, medium and large follicles in CL(+) and CL(-) ovaries) were significantly higher (P≤0.05) when compared with the serum. The FF concentrations of estradiol-17ß and testosterone in same follicle size categories in CL(+) and CL(-) ovaries were also significant (P<0.05). Indeed, concentrations of these hormones in the CL(-) ovaries were higher than those of the CL(+) ovaries. However, there was a statistically significant difference between medium and large follicles for progesterone concentration in CL(+) and CL(-) ovaries (P<0.05). There was a significant correlation between concentration of hormones in serum and FF with increased follicular diameter. CONCLUSIONS: These results indicated that the levels of hormonal composition in the FF were related to follicular size and interestingly to the presence or absence of a corpus luteum. Indeed, the corpus luteum locally affects neighboring follicular compositions during the luteal phase of the estrous cycle in dairy cows.
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The presence of corpus luteum may have a local effect on metabolite composition of follicular fluid (FF) and could indirectly influence follicular development and oocyte quality. The purpose of this study was to examine the influence of the corpus luteum on metabolite composition of follicular fluid (FF), harvested from different-sized follicles and the relationship between metabolite composition of FF to blood serum in dairy cows. Ovaries and blood samples were collected from 30 female adult Holstein Friesian cows, 4-7 years old, with clinically normal reproductive tracts. The animals were in the diestrus stage and selected post mortem. The ovaries collected were classified based on the presence and absence of corpus luteum (CL(+/-)). Visible follicles on the surface of the ovaries were classified into (i) small (3-5mm), (ii) medium (6-9 mm) and (iii) large (10-20mm) based on their diameter. Follicular fluid was aspirated from follicles with different sizes in CL(+) and CL(-) ovaries. Blood and FF samples were analyzed for various biochemical constituents including glucose, cholesterol, triglyceride, total protein, albumin and globulin. The results showed that serum concentration of glucose, cholesterol and triglyceride was significantly different (p≤0.05) in FF from follicles of different size categories. Differences between various follicle size categories in CL(-) ovaries were only significant for concentrations of glucose, cholesterol and triglyceride. FF concentration of glucose and cholesterol in the same follicle size categories in CL(+) ovaries was significantly lower than that of CL(-) ovaries. These results indicate that levels of the biochemical metabolites in serum and FF differ significantly. In addition, FF concentrations of biochemical metabolites were related to follicular size and to the presence or absence of corpus luteum.