RESUMO
Data on human lung histamine H1- and H2-receptors in cancer and chronic inflammatory processes are reported. It has been found that the number of histamine H1-receptors significantly increases both in cancer and chronic pneumonia and does not practically change in tuberculosis lung parenchyma. The binding parameters of histamine H2-receptors both in cancer and inflammatory processes were similar to those obtained for the normal tissue. The important role of parenchymal histamine H1-receptors in the neuromodulation of airways in human lung adenocarcinoma is discussed.
Assuntos
Adenocarcinoma/química , Neoplasias Pulmonares/química , Proteínas de Neoplasias/análise , Receptores Histamínicos H1/análise , Receptores Histamínicos H2/análise , Adenocarcinoma/complicações , Adenocarcinoma/fisiopatologia , Adulto , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/fisiopatologia , Doença Crônica , Cimetidina/metabolismo , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/fisiopatologia , Pessoa de Meia-Idade , Proteínas de Neoplasias/fisiologia , Pneumonia/metabolismo , Pirilamina/metabolismo , Receptores Histamínicos H1/fisiologia , Receptores Histamínicos H2/fisiologia , Tuberculoma/metabolismo , Tuberculose Pulmonar/metabolismoRESUMO
Data on human lung alpha 1- and beta-adrenoceptors and the alpha 1/beta adrenergic ratio in cancer and chronic inflammatory processes are reported. The number of alpha 1-adrenergic sites markedly increased in lung cancer parenchyma, giving a ratio of alpha 1/beta binding sites of 12/1 in cancer but almost 1:1 in control specimens. The alpha 1/beta adrenergic ratio obtained both for mild and severe chronic pneumonia and tuberculosis lung parenchyma was similar to that demonstrated for normal tissue. The above findings suggest the cancer-induced enhancement in parenchymal alpha 1-adrenergic activity.
Assuntos
Adenocarcinoma/metabolismo , Neoplasias Pulmonares/metabolismo , Receptores Adrenérgicos alfa/metabolismo , Receptores Adrenérgicos beta/metabolismo , Adulto , Sítios de Ligação , Doença Crônica , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonia/metabolismo , Ensaio Radioligante , Tuberculose Pulmonar/metabolismoRESUMO
In the present study adrenergic and muscarinic cholinergic receptors have been investigated in human lung parenchyma in cancer and previous airways diseases (chronic pneumonia, tuberculosis). It has been found that the number of muscarinic sites significantly increases in cancer and does not change both in chronic pneumonia and tuberculosis lung parenchyma in comparison with the normal tissue; the number of beta-adrenergic sites decreases in cancer, chronic pneumonia, as well as severe tuberculosis lung parenchyma. The important role of beta-adrenergic and muscarinic receptors in the formation of human lung adenocarcinoma is discussed.