Trends, events and potential sources of Xe-detections in the German radioxenon network.

The measurement of radioxenons (133Xe, 131mXe, 133mXe, 135Xe) in the atmosphere is a keystone for the verification of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). At the German Federal Office for Radiation Protection (Bundesamt für Strahlenschutz, BfS) activity concentrations of radioactive noble gases at several sites in Germany have been measured for more than 5 decades, initially to monitor nuclear facilities and since the mid-1990s also to support the development of measurement and monitoring systems and procedures for verification of the CTBT. Average 133Xe activity concentration in air measured daily at station RN33 of the International Monitoring System (IMS) of the CTBTO on Mt Schauinsland has decreased since 2008. Due to the decreasing radioxenon background in the atmosphere, laboratory measurements with less sensitive proportional counters developed in-house are increasingly replaced by an isotope specific ß-γ laboratory system for radioxenon analyses. Six years of radioxenon activity concentrations measured with the ß-γ laboratory system in weekly samples from monitoring sites in Germany are presented. Activity concentrations of 133Xe in southern Germany are now typically below 1 mBq m-3 and have decreased by an order of magnitude in the past 25 years. Magnitude and variability of 133Xe activity concentrations are generally larger in northern and western Germany compared to the south, most likely due to the prevailing wind directions in the region. Selected, but typical, periods of elevated radioxenon levels at the stations are investigated and the value of stack emission data is demonstrated.

Analysis of radioxenon and Krypton-85 at the BfS noble gas laboratory.

Proportional counters and a ß-γ coincidence system and their performance characteristics are described, with emphasis on internal and external quality controls. Typical limits of detection (LD) are 8mBqm-3 for 85Kr and 4mBqm-3 for 133Xe for the proportional counters, while for similar xenon volumes the LD for 133Xe in the ß-γ system is approximately 4 times lower. Results of comparative analyses agree above the limit of quantification. Xenon-133 levels in southern Germany are presently at or below the LD of the proportional counters, but above the LD of the ß-γ system, which is now routinely used for analysis of environmental samples.

Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase.

As PET candidate tracers for EGFr-TK, five 4-(anilino)quinazoline derivatives, each fluorinated in the aniline moiety, were prepared. Each was tested in vitro for inhibition of EGFr autophosphorylation in A431 cell line. The leading compounds were then radiolabeled with (18)F and cell binding experiments, biodistribution and PET studies in A431 tumor-bearing mice were performed. Metabolic studies were carried out in a mice control group. From our results, we concluded that while in vitro experiments indicates efficacy of 4-(anilino)quinazoline compounds, kinetic factors and rapid blood clearance make them unsuitable as tracers for nuclear medicine imaging of EGFr-TK.