RESUMO
Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus septicemia was fatal in a previously healthy 47-year-old woman. The patient died suddenly in less than 12 hours after presentation, in spite of supportive measures, including ventilation, antibiotic coverage, pressor therapy, and multiple transfusions of blood products. The diagnosis of infection due to an unusual organism was suspected earlier in the course of management after review of the peripheral blood smear. The importance of the findings in the blood smear and their correlation with infection due to this organism are discussed.
Assuntos
Bacteriemia/diagnóstico , Capnocytophaga , Infecções por Bactérias Gram-Negativas/induzido quimicamente , Sepse/diagnóstico , Síndrome de Waterhouse-Friderichsen/diagnóstico , Glândulas Suprarrenais/patologia , Autopsia , Bacteriemia/complicações , Bacteriemia/patologia , Coleta de Amostras Sanguíneas , Evolução Fatal , Feminino , Infecções por Bactérias Gram-Negativas/complicações , Infecções por Bactérias Gram-Negativas/patologia , Humanos , Córtex Renal/patologia , Pessoa de Meia-Idade , Neutrófilos/patologia , Sepse/complicações , Sepse/patologia , Síndrome de Waterhouse-Friderichsen/sangue , Síndrome de Waterhouse-Friderichsen/patologiaAssuntos
Ehrlichia/isolamento & purificação , Ehrlichiose/transmissão , Granulócitos/microbiologia , Transmissão Vertical de Doenças Infecciosas , Complicações Infecciosas na Gravidez , Adulto , Antibacterianos/uso terapêutico , Anticorpos Antibacterianos/sangue , Grupo Borrelia Burgdorferi/imunologia , DNA Bacteriano/análise , Doxiciclina/uso terapêutico , Ehrlichia/genética , Ehrlichia/imunologia , Ehrlichiose/tratamento farmacológico , Feminino , Humanos , Recém-Nascido , GravidezRESUMO
Pseudo-Chédiak-Higashi (PCH) anomaly was seen in a patient with a myelodysplastic syndrome evolving from pancytopenia with normocellular marrow to a myeloblastic leukemia over a period of 72 months. This case is reported.
Assuntos
Síndrome de Chediak-Higashi/patologia , Idoso , Medula Óssea/patologia , Medula Óssea/ultraestrutura , Síndrome de Chediak-Higashi/complicações , Grânulos Citoplasmáticos/ultraestrutura , Humanos , Masculino , Síndromes Mielodisplásicas/complicações , Pancitopenia/complicaçõesRESUMO
Liver scanning with 131Iodine Rose bengal was performed on two patients with histiocytic medullary reticulosis. The diagnosis was confirmed in both cases on subsequent autopsies. The studies demonstrated obstructive pattern in both cases on scanning and correlated well with the biochemical and histological findings. The pathogenesis of jaundice in this condition is reviewed and it is suggested that intrahepatic obstruction plays a significant role in its causation.
Assuntos
Colestase/etiologia , Fígado/diagnóstico por imagem , Doenças Linfáticas/complicações , Idoso , Colestase/diagnóstico por imagem , Colestase/metabolismo , Colestase/patologia , Feminino , Humanos , Fígado/patologia , Masculino , CintilografiaRESUMO
A 70-year-old man experienced pure RBC aplasia after high-dose chlorpropamide therapy. This is the second reported case of pure RBC aplasia associated with chlorpropamide. Cessation of the drug therapy was followed by rapid and sustained complete return to a normal hemoglobin level. A brief review of pure RBC aplasia is presented.