Compact realization of all-attosecond pump-probe spectroscopy.

The ability to perform attosecond-pump attosecond-probe spectroscopy (APAPS) is a longstanding goal in ultrafast science. While first pioneering experiments demonstrated the feasibility of APAPS, the low repetition rates (10 to 120 Hz) and the large footprints of existing setups have so far hindered the widespread exploitation of APAPS. Here, we demonstrate two-color APAPS using a commercial laser system at 1 kHz, straightforward post-compression in a hollow-core fiber, and a compact high-harmonic generation (HHG) setup. The latter enables the generation of intense extreme-ultraviolet (XUV) pulses by using an out-of-focus HHG geometry and by exploiting a transient blueshift of the driving laser in the HHG medium. Near-isolated attosecond pulses are generated, as demonstrated by one-color and two-color XUV-pump XUV-probe experiments. Our concept allows selective pumping and probing on extremely short timescales in many laboratories and permits investigations of fundamental processes that are not accessible by other pump-probe techniques.

Thin-disk laser-pumped OPCPA system delivering 4.4 TW few-cycle pulses.

We present an optical parametric chirped pulse amplification (OPCPA) system delivering 4.4 TW pulses centered at 810 nm with a sub-9 fs duration and a carrier-envelope phase stability of 350 mrad. The OPCPA setup pumped by sub-10 ps pulses from two Yb:YAG thin-disk lasers at 100 Hz repetition rate is optimized for a high conversion-efficiency. The terawatt pulses of the OPCPA are utilized for generating intense extreme ultraviolet (XUV) pulses by high-order harmonic generation, achieving XUV pulse energies approaching the microjoule level.

Generation of above-terawatt 1.5-cycle visible pulses at 1 kHz by post-compression in a hollow fiber.

We report on the generation of 6.1 mJ, 3.8 fs pulses by the compression of a kilohertz Ti:sapphire laser in a large-aperture long hollow fiber. In order to find optimal conditions for spectral broadening at high pulse energies, we explore different parameter ranges where ionization or the Kerr effect dominates. After identifying the optimum parameter settings, large spectral broadening at high waveguide transmission is obtained. The intense 1.5-cycle pulses are used for high-harmonic generation in argon and neon.

Full characterization of 8 fs deep UV pulses via a dispersion scan.

We report on, to the best of our knowledge, the first characterization of deep ultraviolet (UV) pulses by the dispersion scan (d-scan) technique. Negatively chirped 8 fs deep UV pulses are generated via the phase transfer of shaped few-cycle near-infrared pulses in a sum frequency generation process with narrowband second harmonic. The pulses are characterized by a d-scan technique incorporating a cross-polarized wave (XPW) generation nonlinearity. Being a single-beam degenerate four-wave mixing process, XPW does not acquire frequency conversion and, thus, is ideally suited for characterizing pulses in the UV, where the material dispersion severely limits phase matching. The characterization method is benchmarked by measuring the dispersion effect of a known fused silica plate on the pulses.

Compression of picosecond pulses from a thin-disk laser to 30fs at 4W average power.

We investigate two approaches for the spectral broadening and compression of 1-ps long pulses of a thin-disk laser amplifier running at 50 kHz repetition rate at 1030 nm wavelength. We find that with a single, 2.66-m long stretched flexible hollow fiber filled with xenon gas, Fourier transform limited output pulse duration of 66 fs can be directly reached. For larger pulse shortening, we applied a hybrid cascaded approach involving a BBO-based pre-compressor and a long hollow fiber. We could achieve 33-times temporal shortening of 1-ps pulses down to a duration of 30 fs at an overall efficiency of ~29% with an output power level of 3.7 W. These results demonstrate the potential of stretched flexible fibers with their free length scalability for shortening laser pulses of moderate peak power.

Few-cycle optical pulse characterization via cross-polarized wave generation dispersion scan technique.

We demonstrate a dispersion scan (d-scan) pulse characterization scheme employing cross-polarized wave (XPW) generation as a nonlinear optical process. XPW generation is a degenerate four-wave mixing process with no phase-matching limitations. Therefore, its implementation in the d-scan method is a good choice for the characterization of few-cycle pulses in remote spectral regions. We fully characterize 5-10 fs pulses delivered through a hollow-core fiber in the near-IR region and compare the results with the second-harmonic generation (SHG) frequency-resolved optical gating and SHG d-scan characterization methods.

Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla.

PURPOSE: This work aimed to compare the diagnostic performance of a metal artifact suppression sequence (MAVRIC-SL) for imaging of hip arthroplasties (HA) at 1.5 and 3 Tesla (T) field strength. METHODS: Eighteen patients (10 females; aged 27-74) with HA were examined at 3.0 and 1.5 T within 3 weeks. The sequence protocol included 3D-MAVRIC-SL PD (coronal), 3D-MAVRIC-SL STIR (axial), FSE T1, FSE PD and STIR sequences. Anatomical structures and pathological findings were assessed independently by two radiologists. Artifact extent and technical quality (image quality, fat saturation and geometric distortion) were also evaluated. Findings at 1.5 and 3.0 T were compared using a Wilcoxon signed rank test. RESULTS: While image quality was better at 1.5 T, visualization of anatomic structures and clinical abnormalities was not significantly different using the two field strengths (p > 0.05). Fat suppression and amount of artifacts were significantly better at 1.5 T (p < 0.01). Inter- and intra-reader agreement for different anatomic details, image quality and visualization of abnormalities ranged from k = 0.62 to k = 1.00. CONCLUSION: MAVRIC-SL at 1.5 T had a comparable diagnostic performance when compared MAVRIC-SL at 3.0 T; however, the higher field strength was associated with larger artifacts, limited image quality and worse fat saturation.

Direct observation of pulse dynamics and self-compression along a femtosecond filament.

We report on the direct experimental observation of pulse-splitting dynamics along a femtosecond filament. The fundamental pulse experiences a significant self-shortening during the propagation leading to pulse durations of 5.3 fs, corresponding to sub-3 cycles, which is measured without external pulse compression. A compression factor of eight could be achieved in a single filamentary stage. Theoretical modeling of the fundamental pulse propagation confirms our observed pulse structures and durations and gives further insight into the nonlinear dynamics during filamentation.

Sub-1.5-cycle pulses from a single filament.

The temporal dynamics of ultrashort laser pulses undergoing filamentary propagation are investigated with a real-time stereographic above-threshold ionization (ATI) phasemeter. The experimental setup is capable of measuring the pulse duration as well as the carrier-envelope phase distribution of pulses originating from a femtosecond filament, which is either truncated in length or fully propagated. Truncation, by means of a semi-infinite gas cell, allows to elucidate the nonlinear evolution and temporal dynamics of ultrashort laser pulses as a function of the propagation length. We observe the formation of few-cycle pulses as well as temporal pulse splitting dynamics during the propagation of the pulse inside the filament. For the first time, we demonstrate the compression of 35 fs pulses down to a duration of sub-4 fs in a single femtosecond filament. This corresponds to sub-1.5 cycles of the electric field.

Biodegradable polylactide membranes for bone defect coverage: biocompatibility testing, radiological and histological evaluation in a sheep model.

Large bony defects often show a delayed healing and have an increasing risk of infection. Several materials are used for the coverage of large defects. These materials must be biocompatible, easy to use, and must have an appropriate stability to present a mechanical hindrance. Aim of this study was to investigate two different biodegradable membranes for defect coverage in a sheep model. Round cranial defects (1.5 cm diameter) were created in sheep. Six different treatments were investigated: defects without membrane, defects covered with a poly(D,L-lactide) or with a 70/30 poly(L/D,L-lactide) membrane and all defects with or without spongiosa filling. The sheep were sacrificed 12 or 24 weeks postoperatively. Bone formation in the defects was quantified by computer-assisted measurements of the area of the residual defect on CT radiographs. Histomorphometry and host-tissue response were evaluated by light microscopy. The biocompatibility was investigated by analyzing the amount of osteoclasts and foreign body cells. Both membranes served as a mechanical hindrance to prevent the prolapse of soft tissue into the defect. The biocompatibility test revealed no differences in the amount and distribution of osteoclasts at the two investigated time points and between the investigated groups. No negative effect on the tissue regeneration was detectable between the investigated groups related to the type of membrane, but a foreign body reaction around the two membrane types was observed. In the membrane-covered defects, the spongiosa showed a progressing remodeling to the native bony structure of the cranium. The groups without spongiosa partly revealed new bone formation, without complete bridging in any group or at any time point. Comparing the 12 and 24 weeks groups, an increased bone formation was detectable at the later time point. In conclusion, the results of the present in vivo study reveal a good biocompatibility and prevention of soft tissue prolapse of the two used membranes without differences between the membranes. An enhanced remodeling of the spongiosa into native bony structures under the membranes was detectable, but no osteopromoting effect was observed due to the membranes.