[The use of artificial hyperglycemia in the radiotherapy of patients with rectal cancer]. / Ispol'zovanie iskusstvennoi giperglikemii pri luchevom lechenii bol'nykh rakom priamoi kishki.

A treatment modality employing radiotherapy with subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally--extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patients who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side--effects developed. The results are encouraging and seem to open up new vistas of clinical research.

[Enhancement of ionizing radiation effects on transplantable cerebral gliomas using short-term hyperglycemia]. / Usilenie éffekta deistviia ioniziruiushchego izlucheniia na perevivnye gliomy golovnogo mozga posredstvom kratkovremennoi giperglikemii.

Experiments were staged on rats with transplantable anaplastic cerebral right hemisphere astrocytomas. Hyperglycemia was induced by means of intraperitoneal fractional administration of 40% glucose solution. Single local x-ray tumor irradiation followed on the 4-5th, 7-8th and 10-12th days after strain transplantation at the doses of 30 and 40 Gy without hyperglycemia and in combination with it. The irradiation effect was assessed by the mean survival time of the animals. Hyperglycemia was shown to increase significantly radiation injury of highly resistant experimental malignant cerebral glial tumors.