[Subthreshold micropulse laser treatment of the foveal region in chronic central serous chorioretinopathy (case study)]. / Subporogovoe mikroimpul'snoe vozdeistvie v foveal'noi oblasti pri khronicheskoi tsentral'noi seroznoi khorioretinopatii (klinicheskoe nablyudenie).

The article presents a clinical case of subthreshold micropulse laser (SML) treatment of chronic central serous chorioretinopathy (CSC) in the left eye of a 44-year-old female patient K. with dye allergy. The patient first noticed a gray spot, distortion of objects in February, 2018. During 2018-2020 she suffered 5 relapses, repeated unsuccessful conservative treatment, and completed a course of antiangiogenic therapy in the form of three monthly intravitreal injections of ranibizumab. After experiencing stress on 11.08.20 she noted acute deterioration. Laser treatment was carried out on 20.09.20 with the Navilas 577s navigation system (wavelength 577 nm). After the power titration and calculation, the contact-free subthreshold micropulse laser treatment was carried out without anesthesia in three zones: 200 mW for fovea, 240 mW for parafovea and 340 mW for periphovea. Other settings: pulse duration - 200 ms, spot diameter - 100 µm, duty cycle - 5%. Total number of laser pulses - 1000. The retina reattached completely despite the patient having previously recovered from the coronavirus infection and the use of corticosteroids.

[Age-related changes in human vitreous]. / Vozrastnye izmeneniya steklovidnogo tela.

There are two main age-related changes that can occur in the vitreous body of healthy individuals throughout life: liquefaction (synchesis) and aggregation of collagen fibrils into dense bundles (syneresis). Progressive age-related degradation leads to posterior vitreous detachment (PVD). At present many classifications of PVD exist, in which authors relied either on the morphological features, or on the differences in pathogenesis before and after widespread use of OCT. The course of PVD can be either normal or anomalous. Physiological PVD induced by age-related vitreous changes progresses in specific stages. The review emphasizes that PVD can occur initially not only in the central zone of the retina, but also on the periphery with further spread to the posterior pole. Anomalous PVD can lead to various negative effects on the retina, as well as on the vitreous as a result of traction in the area of vitreoretinal interface.

[Widefield optical coherence tomography as an effective method for detecting imperceptible flap retinal tears (clinical observation)]. / Shirokopol'naya opticheskaya kogerentnaya tomografiya ­ effektivnyi metod vyyavleniya klapannogo razryva setchatki (klinicheskoe nablyudenie).

Certain late peripheral ruptures after acute posterior vitreous detachment (PVD) may remain undetected during the initial examination of the fundus due to the presence of vitreous hemorrhages and other factors, but they can lead to rhegmatogenic retinal detachment in the future. Hence, it is necessary to conduct an additional thorough examination using optical coherence tomography (OCT) of the vitreoretinal interface periphery in the presence of tear predictors: retinal and vitreal hemorrhages, vitreous pigment cells ("tobacco dust") in the anterior segment of the vitreous body, as well as hyper-reflective dots ("starry sky") in the vitreous body according to OCT scans of patients with acute symptomatic detachment of the hyaloid membrane. The article presents the case of a patient with a clinically imperceptible flap tear detected during acute posterior vitreous detachment. Widefield OCT of the vitreoretinal interface was performed by "sliding" from the center to the periphery of the retina, and revealed a flap tear located next to a dot retinal hemorrhage. OCT scanning of the retinal periphery is an effective modern diagnostic method in the ophthalmological clinical practice.

[OCT visualization of hyporeflective lacuna in the retrolental space]. / OKT-assotsiirovannaya vizualizatsiya giporeflektivnoi lakuny v retrolental'nom prostranstve.

PURPOSE: To investigate the vitreo-lenticular interface and anterior vitreous using high-resolution optical coherence tomography (OCT). MATERIAL AND METHODS: This prospective single-center pilot study included 34 patients (68 eyes) - 6 males and 28 females with a mean age of 58.4±12.0 years (age range 24-81 years). OCT scanning was performed on the spectral domain optical coherence tomography (SD-OCT) device SOLIX (OPTOVUE, USA) in the Full Range AC mode with the following scan parameters: from 14 to 18 mm in horizontal length and 6.25 mm in the axial dimension. To improve the signal-to-noise ratio and increase image clarity of the final scan, averaging of eight simultaneous scans was performed. RESULTS: In all healthy volunteers, hyporeflective retrolental cavities-lacunae were observed in both eyes during visualization of the retrolental space in the horizontal and vertical planes. The median distance from the posterior pole of the lens to the lacuna was 697 µm. The median width of the lacuna was 157 µm. CONCLUSION: To the best of our knowledge, we consider this to be one of the first in vivo visualizations of a previously undescribed structure - hyporeflective retrolental lacuna - using SOLIX high-resolution OCT device. The retrolental lacuna may play the role of a buffer system, or belong to the lymphatic system of the vitreous body and the eye.

[Retrolental amyloidosis of the vitreous body (case study)]. / Retrolental'nyi amiloidoz steklovidnogo tela (klinicheskoe nablyudenie).

Accumulations of pathological amyloid protein in the vitreous can be a pathognomonic morphological sign of systemic amyloidosis, which is characterized by deposition of insoluble fibrillar protein aggregates (amyloid) in various organs and tissues. The article describes a clinical case of a female 65-year-old patient with bilateral vitreous floaters and histologically confirmed vitreous amyloidosis on the right eye. The patient had undergone YAG laser vitreolysis of the right eye 3 years ago on the Ultra Q Reflex system («Ellex¼, Australia) to treat an atypical Weiss ring. Diagnosis of vitreous amyloidosis was confirmed using the following equipment: video slit lamp SL9900 («CSO¼, Italy), optical coherence tomography system Solix («Optovue¼, USA), B-scan Plus («Accutome¼, USA), microscope CX41RF («Olympus Corporation¼, Japan). Due to significant visual deterioration in the right eye, the patient underwent vitrectomy. Microscopic examination of the surgical sample showed the presence of amyloid deposits revealed by the brick-red specific staining with congo red dye and apple-green birefringence of the stained areas in polarized light.