1.
Bioorg Med Chem Lett
; 19(13): 3426-9, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19481451
RESUMO
We successfully discovered peptidomimetic motilin antagonists (17c and 17d) through the improvement of physicochemical properties of a tetrapeptide antagonist (2). Furthermore, with oral administration and based on motilin antagonistic activity, both compounds suppressed motilin-induced colonic and gastric motility in conscious dogs.