Brain and muscle activation patterns during postural control affect static postural control.

BACKGROUND: Previous studies have reported existence of coordinated brain and muscle activity patterns that affect postural control. However, differences in these activity patterns that affect postural control are still unclear. The purpose of this study was to clarify brain and muscle activity pattern affecting postural control. RESEARCH QUESTION: Does the difference in brain and muscle activity patterns during postural control affect postural control ability? METHOD: Nineteen healthy men (mean age: 24.8 ± 4.1 years, height: 171.8 ± 5.5 cm, and weight: 63.5 ± 12.5 kg) performed a postural control task on a balance board, and their brain and muscle activities and body sway during the task were measured using functional near-infrared spectroscopy, surface electromyography, and three-dimensional accelerometry. Hierarchical cluster analysis was conducted to extract subgroups based on brain and muscle activities and postural control, and correlation analysis was performed to investigate the relationship between brain activity, muscle activity, and postural control. RESULTS: Two subgroups were found. Subgroup 1 (n = 9) showed higher brain activity in the supplementary motor area (p = 0.04), primary motor cortex (p = 0.04) and stable postural control in the mediolateral (p < 0.01) planes, and subgroup 2 (n = 10) showed higher muscle activity in the tibialis anterior (p < 0.01), a higher shank muscles co-contraction (p = 0.02) and unstable postural control. Furthermore, the supplementary motor area activity is negatively correlated with body sway of mediolateral plane (r = -0.51, p = 0.02), and tibialis anterior activity is positively correlated with body sway on the mediolateral plane (r = 0.62, p = 0.004). SIGNIFICANCE: Higher brain activity in motor-related areas, lower activity in the lower limb muscles and lower co-contraction of shank muscles were observed in stable postural control. These results will facilitate the planning of new rehabilitation methods for improving postural control ability.

Comparison of Functional Connectivity during Visual-Motor Illusion, Observation, and Motor Execution.

This study investigated the functional connectivity during visual-motor illusion and compared it with observation and motor execution using functional near-infrared spectroscopy (fNIRS). Thirty subjects were randomly assigned to: illusion, observation, and motor execution group. Illusion group watched own finger joint movement video image and induced kinesthetic illusion, while the other group only performed observation or motor execution. Continuous brain activity was measured using fNIRS and functional connectivity was analyzed. The illusion group perceived (using 7-point Likert scale) a higher degree of kinesthetic illusion and sense of body ownership than the observation group. Visual-motor illusion was associated with stronger functional connectivity between the left premotor cortex and the left parietal area compared with observation and motor execution only, suggesting that these areas respond to visual-motor illusion.

Effects of visual-motor illusion on functional connectivity during motor imagery.

This study aimed to verify whether visual-motor illusion changes the functional connectivity during kinesthetic motor imagery and the vividness of kinesthetic motor imagery. Twelve right-handed healthy adults participated in this study. All participants randomly performed both the illusion and observation conditions in 20 min, respectively. Illusion condition was induced kinesthetic illusion by viewing own finger movement video. Observation condition was observed own finger movement video. Before and after each condition, the brain activity of kinesthetic motor imagery was measured using functional near-infrared spectroscopy. The measure of brain activity under kinesthetic motor imagery was executed in five sets using block design. Under the kinesthetic motor imagery, participants were asked to imagine the movement of their right finger. Functional connectivity was analyzed during the kinesthetic motor imagery. In addition, after performing the task under kinesthetic motor imagery, the vividness of the kinesthetic motor imagery was measured using a visual analog scale. Furthermore, after each condition, the degree of kinesthetic illusion and sense of body ownership measured based on a seven-point Likert scale. Our results indicated that the functional connectivity during kinesthetic motor imagery was changed in the frontal-parietal network of the right hemisphere. The vividness of the kinesthetic motor imagery was significantly higher with the illusion condition compared with the observation condition. The degree of kinesthetic illusion and sense of body ownership were significantly higher with the illusion condition compared with the observation condition. In conclusion, the visual-motor illusion changes the functional connectivity during kinesthetic motor imagery and influences the vividness of kinesthetic motor imagery. The visual-motor illusion provides evidence that it improves motor imagery ability. VMI may be used in patients with impaired motor imagery.

Immediate effects of visual-motor illusion on resting-state functional connectivity.

Visual-motor illusion (VMI) is to evoke a kinesthetic sensation by viewing images of oneself performing physical exercise while the body is at rest. Previous studies demonstrated that VMI activates the motor association brain areas; however, it is unclear whether VMI immediately alters the resting-state functional connectivity (RSFC). This study is aimed to verify whether the VMI induction changed the RSFC using functional near-infrared spectroscopy (fNIRS). The right hands of 13 healthy adults underwent illusion and observation conditions for 20 min each. Before and after each condition, RSFC was measured using fNIRS. After each condition, degree of kinesthetic illusion and a sense of body ownership measured using the Likert scale. Our results indicated that, compared with the observation condition, the degree of kinesthetic illusion and the sense of body ownership were significantly higher after the illusion condition. Compared with the observation condition, RSFC after the illusion condition significantly increased brain areas associated with kinesthetic illusion, a sense of body ownership, and motor execution. In conclusion, RSFC has become a biomarker that shows changes in brain function occurring due to VMI. VMI may be applied to the treatment of patients with stroke or orthopedic diseases.

Hippocampal acetylcholine efflux increases during negative patterning and elemental discrimination in rats.

The purpose of this paper is to examine whether hippocampal acetylcholine (ACh) efflux increases during negative patterning (NP) discrimination tasks. For these tasks, a rat's response was rewarded when either a single stimulus A (tone) or stimulus B (light) was presented, but was not rewarded when the compound stimulus AB (tone+light) was presented to the NP group of rats. An elemental discrimination (E) task was given to another group (E group). In the E group, the rat's response was rewarded when one of two stimuli (e.g., tone) was presented, but not rewarded when the other stimulus (e.g., light) was presented. After reaching a learning criterion, a guide cannula was implanted into dorsal hippocampus under anesthesia. In test sessions, rats were given the same task as before the guide cannula implantation, and ACh efflux was measured. Hippocampal ACh efflux increased during both NP and E tasks. In addition, the magnitude of increase was higher in the NP group than in the E group. Thus, over all our results demonstrate that task difficulty is a critical factor that relates to the difference in ACh efflux in the hippocampus.