Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Hérnia Hiatal , Úlcera Péptica Perfurada/cirurgia , Úlcera Gástrica , Idoso de 80 Anos ou mais , Feminino , Hérnia Hiatal/complicações , Hérnia Hiatal/diagnóstico , Humanos , Laparotomia/métodos , Úlcera Péptica Perfurada/diagnóstico , Úlcera Péptica Perfurada/fisiopatologia , Úlcera Gástrica/complicações , Úlcera Gástrica/diagnóstico , Tomografia Computadorizada Espiral/métodos , Resultado do TratamentoRESUMO
Development of behavioral disturbances was investigated during N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration (0,2 mg/kg, i/m, at 48 h. intervals, total dose 11.2-13.2 mg/kg) in experiments on two monkeys Macaca rhesus. MPTP induced the complex of symptoms, which are typical for idiopathic Parkinson's disease. Administration of amiridine (0,25-0,4 mg/kg) to MPTP-treated monkeys caused gradual decline of Parkinson syndrome. Mechanisms of action of amiridine are discussed.
Assuntos
Aminoquinolinas/uso terapêutico , Inibidores da Colinesterase , Modelos Animais de Doenças , Doença de Parkinson Secundária/tratamento farmacológico , Psicotrópicos/uso terapêutico , 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina , Animais , Comportamento Animal/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Feminino , Macaca mulatta , Masculino , Doença de Parkinson Secundária/induzido quimicamente , Fatores de TempoRESUMO
Horizontal eye movements in cats were recorded using the magnetic search coil method. Saccadic eye movements were linearly approximated. For combined eye and head movements the slope of lines was independent of maximal head velocity within the studied range (up to 250 degree/s). Saccades slowed down with a restrained head. The duration of the gaze shift grew with an increase of its amplitude. The amplitude of gaze was found to depend on the head velocity. Experimental data on the interaction of eye and head movements during the coordinated goal displacements are interpreted from standpoint of the saccadic signal suppression by the "efferent copy" signal for head movements.
Assuntos
Vias Eferentes , Movimentos Oculares , Movimentos Sacádicos , Animais , Gatos , Cabeça , MovimentoRESUMO
Horizontal displacements of gaze in cats with unrestrained head were studied using the magnetic search coil method. Three types of eye-head coordination were found when cats oriented gaze towards visual targets. Maximal velocities of gaze, head and eye movements in orbits depend linearily on amplitudes of their displacements in the range of up to 20 degrees. Gaze velocity reached its top level in about 0.3 of complete time of movement execution. Data support the idea of saccadic-vestibular summation during coordinated eye-head movements in cats.