Spontaneous cutaneous umbilical endometriosis: report of a new case with immunohistochemical study and literature review.

Endometriosis (i.e., the presence of functional endometrial tissue outside the uterine cavity) may rarely affect the skin either spontaneously or secondary to abdomino-pelvic surgery. Spontaneous cutaneous endometriosis appears most commonly on the umbilicus (Villar nodule) and manifests with a red-brown nodule that characteristically shows cyclic variations (tenderness or bleeding) with the menstrual cycle. We present herein a new case of spontaneous cutaneous endometriosis of the umbilicus that was studied immunohistochemically and review the salient clinicopathologic features of this rare condition.

Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride.

OBJECTIVE: Our goal was to report a case of malignant neuroleptic syndrome in a patient administered with both oxcarbazepine (OXCBZ) and amisulpride (AM). METHOD: We present a case of a young man who presented with symptoms of malignant neuroleptic syndrome after progressive titration of OXCBZ (1,200 mg) added to the long-term treatment with AM (800 mg). RESULTS: After discontinuation of AM and administration of dopaminergic drugs, his clinical symptoms improved gradually. CONCLUSION: This case suggests that clinicians should consider the risk of neuroleptic malignant syndrome when OXCBZ is coadministered to patients undergoing long-term treatment with neuroleptics.