[Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro].

OBJECTIVE: To study the effects of azone on the percutaneous absorption of baicalin in vitro. METHODS: Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined. RESULTS: The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%. CONCLUSION: C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%.