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1.
Artigo em Inglês | MEDLINE | ID: mdl-27326983

RESUMO

BACKGROUND AND OBJECTIVE: There is little information on pregnancy and delivery in patients with hereditary angioedema due to C1 inhibitor deficiency (C1INH-HAE). The aim of this study was to describe the effect of pregnancy and deliveries on symptoms of C1INH-HAE and review the need for and safety of treatments available during the study period. METHODS: Retrospective review using a purpose-designed questionnaire of 61 C1INH-HAE patients from 5 hospitals specialized in the management of HAE in Spain. The outcomes measured were number of pregnancies, changes in symptoms during pregnancy and delivery, mode of delivery, type of anesthesia during delivery, treatments received, and tolerance of treatments. RESULTS: We reviewed 125 full-term pregnancies (89 without a prior diagnosis of C1INH-HAE), 14 miscarriages, and 4 induced abortions. Patients reported an increased frequency of C1INH-HAE symptoms in 59.2% of pregnancies (74/125) and the presence of symptoms throughout pregnancy in 40% (50/125). Prophylactic C1INH-HAE therapy was used during 9 (7.2%) of the 125 pregnancies. Nine patients--in 11 pregnancies (8.8 %)--received treatment for acute attacks. Most deliveries (n=110, 88%) were vaginal. A cesarean section was necessary in 15 cases (12%). Short-term prophylaxis with pdhC1INH was administered before 14 deliveries (11.2 %); 111 deliveries (88.8 %) were performed without premedication and were well tolerated. Anesthesia was used in 51 deliveries (40.8%). CONCLUSIONS: Pregnancy has a variable influence on the clinical expression of C1INH-HAE. Attacks tend to occur more frequently but not to increase in severity. Vaginal delivery was mostly well tolerated. pdhC1INH prophylaxis should be administered prior to cesarean delivery and is also recommended before vaginal delivery if there are additional risk factors. pdhC1INH should always be available in the delivery room.


Assuntos
Angioedemas Hereditários/terapia , Complicações na Gravidez/terapia , Adolescente , Adulto , Parto Obstétrico , Feminino , Humanos , Gravidez , Estudos Retrospectivos
2.
J Investig Allergol Clin Immunol ; 25(5): 358-64, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26727765

RESUMO

BACKGROUND: Hereditary angioedema due to C1-esterase inhibitor deficiency (HAE-C1-INH) is a life-threatening disease. OBJECTIVES: To describe the clinical characteristics and management of patients with HAE-C1-INH during routine clinical practice. METHODS: An observational, retrospective study was performed in patients with HAE-C1-INH. Demographic, clinical, and analytical data were collected from 2 periods: period A (October 2009-September 2010) and period B (October 2007-September 2009). RESULTS: We studied 112 patients with HAE-C1-INH (57.1% females). Age at onset of symptoms was 14.4 years (lower in patients who had experienced attacks in the previous year). In period B (n=87), 62.1% of patients presented at least 1 edema attack (median, 3.5 attacks/patient/2 years), and 19.1% of attacks were treated. In period A (n=77), 58.4% of patients were on maintenance therapy. Stanozolol was the most widely used drug (48.9%), with a mean weekly dose of 6.7 mg. At least 1 attack was recorded in 72.7% of patients (median, 3.0 attacks/patient/year), and 31.5% of the attacks were treated. Treatment of acute attacks increased by 12.4%. CONCLUSION: Age at onset of symptoms is associated with clinical expression of disease. The higher age at onset of symptoms, the fewer number of attacks per patient and year, and the lower dose of attenuated androgens necessary to control the disease than in other series lead us to hypothesize that HAE-C1-INH could have a less severe expression in Spain. Acute attacks seem to be treated increasingly often.


Assuntos
Androgênios/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Antifibrinolíticos/uso terapêutico , Bradicinina/análogos & derivados , Proteína Inibidora do Complemento C1/uso terapêutico , Angioedema Hereditário Tipos I e II/tratamento farmacológico , Adolescente , Adulto , Idoso , Bradicinina/uso terapêutico , Criança , Pré-Escolar , Gerenciamento Clínico , Feminino , Angioedema Hereditário Tipos I e II/etiologia , Angioedema Hereditário Tipos I e II/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
3.
J Investig Allergol Clin Immunol ; 24(6): 425-30, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25668894

RESUMO

BACKGROUND: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is characterized by fever, rash, eosinophilia, and multiorgan failure. Previous reports have described differences in clinical and laboratory findings of DRESS syndrome depending on the inducing drug. Piperacillin has been reported as the drug responsible for this syndrome in 3 patients. OBJECTIVE: To analyze and describe the clinical, laboratory, and allergy study findings of piperacillin-induced DRESS. PATIENTS AND METHODS: Retrospective case series of patients diagnosed with DRESS associated with piperacillin-tazobactam (Pip/Taz) according to the Kardaun diagnostic score criteria. Assessment of causality was established using the Spanish Pharmacovigilance System and the lymphocyte transformation test (LTT). The allergy study included skin and epicutaneous tests. RESULTS: Eight patients were diagnosed with DRESS due to Pip/Taz (3 probable and 5 definite cases). Skin rash was observed in all cases and facial edema in 50%; the mean latency period was 18 days. Fever was present in 7 patients. Liver and kidney injuries were detected in 6 and 3 patients, respectively. All patients had eosinophilia and a full recovery. The LTT to Pip/Taz was strongly positive in all patients, with a stimulation index of over 6. Three of 3 patients had a positive intradermal test to Pip/Taz, and 1 of 4 had a positive patch test. All patients had a negative LTT to carbapenems. CONCLUSIONS: We have reported on the first case series of piperacillin-induced DRESS. A latency period of 18 days, skin rash, eosinophilia, fever, liver injury, and good prognosis were the most common features. The allergy study, and the LTT in particular, was highly useful for identifying Pip/Taz as the culprit drug and piperacillin as the responsible active ingredient.


Assuntos
Antibacterianos/efeitos adversos , Hipersensibilidade a Drogas/diagnóstico , Ácido Penicilânico/análogos & derivados , Adulto , Idoso , Hipersensibilidade a Drogas/tratamento farmacológico , Feminino , Humanos , Ativação Linfocitária , Masculino , Pessoa de Meia-Idade , Ácido Penicilânico/efeitos adversos , Piperacilina/efeitos adversos , Combinação Piperacilina e Tazobactam , Estudos Retrospectivos , Síndrome
5.
Artigo em Inglês | MEDLINE | ID: mdl-23653967

RESUMO

BACKGROUND: Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) has considerable implications for dental health care providers, since dental procedures may trigger severe and even life-threatening episodes. The aim of the present study was to analyze the efficacy and safety of premedication with attenuated androgens (AAs), plasma-derived human C1 esterase inhibitor concentrate (pdhC1INH), or both to prevent the development of upper airway angioedema after dental-oral procedures in patients with HAE-C1-INH. MATERIAL AND METHODS: All dental-oral procedures performed on patients with HAE-C1-INH who were followed up at La Paz University Hospital, Madrid, Spain were reviewed. Demographic data, maintenance treatment, preprocedure prophylaxis, disease severity, and occurrence of upper airway angioedema were recorded. RESULTS: Twenty-four patients (14 male/10 female; mean age, 42.6 years) underwent 66 procedures. Most procedures were performed on patients with severe HAE-C1-INH (20 procedures) or moderate HAE-C1-INH (26 procedures). Only 9 procedures were performed without short-term prophylaxis. Mild upper airway angioedema developed after 3 procedures performed without short-term prophylaxis in patients with minimal or asymptomatic HAE-C1-INH. A statistically significant association was found between development of mild postprocedure upper airway angioedema and lack of maintenance treatment with AA, lack of increased dose of preprocedure AA, and failure to administer preprocedure pdhC1INH (P = .002, Fisher exact test). CONCLUSIONS: Increased doses of prophylactic AA, administration of pdhC1INH, or both were good options for ambulatory management of dental-oral procedures in patients with HAE-C1-INH. Prophylaxis with pdC1INH or increased doses of AA is advisable before dental-oral procedures, even in patients with low disease severity.


Assuntos
Androgênios/uso terapêutico , Proteína Inibidora do Complemento C1/uso terapêutico , Angioedema Hereditário Tipos I e II/tratamento farmacológico , Angioedema Hereditário Tipos I e II/etiologia , Complicações Pós-Operatórias , Pré-Medicação , Doenças Estomatognáticas/complicações , Adulto , Androgênios/efeitos adversos , Proteína Inibidora do Complemento C1/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Estomatognáticas/cirurgia , Adulto Jovem
6.
J Investig Allergol Clin Immunol ; 21(6): 422-41; quiz 442-3, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21995176

RESUMO

BACKGROUND: There are no previous Spanish guidelines or consensus statements on bradykinin-induced angioedema. AIM: To draft a consensus statement on the management and treatment of angioedema mediated by bradykinin in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals. METHODS: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema, a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings were held to reach the consensus. RESULTS: Treatment approaches are discussed, and the consensus reached is described. Specific situations are addressed, namely, pregnancy, contraception, travelling, blood donation, and organ transplantation. CONCLUSIONS: A review of and consensus on treatment of bradykinin-induced angioedema is presented.


Assuntos
Angioedema , Bradicinina/antagonistas & inibidores , Angioedema/diagnóstico , Angioedema/metabolismo , Angioedema/terapia , Bradicinina/metabolismo , Humanos , Prognóstico
7.
J Investig Allergol Clin Immunol ; 21(5): 333-47; quiz follow 347, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21905496

RESUMO

BACKGROUND: There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema. AIM: To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals. METHODS: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings of the SGBA were held in Madrid to reach the consensus. RESULTS: The pathophysiology, genetics, and clinical symptoms of the different types of angioedema are reviewed. Diagnostic approaches are discussed and the consensus reached is described. CONCLUSIONS: A review of bradykinin-induced angioedema and a consensus on diagnosis are presented.


Assuntos
Angioedema , Bradicinina/efeitos adversos , Vasoespasmo Coronário/tratamento farmacológico , Hipersensibilidade a Drogas/fisiopatologia , Vasodilatadores/efeitos adversos , Angioedema/classificação , Bradicinina/uso terapêutico , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/epidemiologia , Hipersensibilidade a Drogas/genética , Serviços Médicos de Emergência , Medicina Baseada em Evidências , Prova Pericial , Humanos , Guias de Prática Clínica como Assunto , Fatores de Risco , Espanha , Vasodilatadores/uso terapêutico
8.
Artigo em Inglês | MEDLINE | ID: mdl-20945612

RESUMO

Drug-related rash with eosinophilia and systemic symptoms (DRESS) syndrome, or drug-induced hypersensitivity syndrome (DIHS), is a life-threatening multiorgan systemic reaction characterized by rash, fever, lymphadenopathy, hepatitis, and leukocytosis with eosinophilia. Aromatic anticonvulsant drugs and allopurinol have been reported to be the most frequent eliciting agents. Our search of the literature revealed only 2 cases induced by piperacillin and 1 case by ceftriaxone.We present 2 cases of DRESS syndrome induced by the beta-lactam drugs ceftriaxone and piperacillin-tazobactam. An allergological workup including skin prick test, intradermal tests, patch tests, and lymphocyte transformation test (LTT) was performed. LTT was shown to be a useful technique in both cases to help to identify the drugs involved.


Assuntos
Anticonvulsivantes/efeitos adversos , Ceftriaxona/efeitos adversos , Hipersensibilidade a Drogas/diagnóstico , beta-Lactamas/efeitos adversos , Corticosteroides/administração & dosagem , Adulto , Anticonvulsivantes/administração & dosagem , Anticonvulsivantes/farmacologia , Ceftriaxona/administração & dosagem , Ceftriaxona/farmacologia , Proliferação de Células/efeitos dos fármacos , Células Cultivadas , Colite Ulcerativa/tratamento farmacológico , Hipersensibilidade a Drogas/tratamento farmacológico , Hipersensibilidade a Drogas/imunologia , Hipersensibilidade a Drogas/fisiopatologia , Eosinofilia , Epilepsia/tratamento farmacológico , Exantema , Feminino , Antagonistas dos Receptores Histamínicos/administração & dosagem , Humanos , Ativação Linfocitária/efeitos dos fármacos , Masculino , Ácido Penicilânico/administração & dosagem , Ácido Penicilânico/efeitos adversos , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/farmacologia , Piperacilina/administração & dosagem , Piperacilina/efeitos adversos , Piperacilina/farmacologia , Combinação Piperacilina e Tazobactam , beta-Lactamas/administração & dosagem , beta-Lactamas/farmacologia
9.
J Investig Allergol Clin Immunol ; 20(5): 437-41, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20945613

RESUMO

Hypersensitivity to Anisakis is an increasingly prominent medical problem throughout the world, due to a better understanding of diseases induced by parasites and to modern culinary habits of eating raw or undercooked fish. We describe the case of a patient who presented epigastric pain, wheals, erythema, and pruritus 3 hours after the ingestion of fish. More than 200 larvae were obtained by endoscopy. However, the patient only developed an immune response with specific immunoglobulin E and eosinophilia peaking at day 18 and decreasing during the 17-month follow-up. Only eosinophilia reached normal limits.


Assuntos
Anisaquíase/diagnóstico , Anisakis/imunologia , Anticorpos Anti-Helmínticos/imunologia , Antígenos de Helmintos/imunologia , Imunoglobulina E/imunologia , Adulto , Animais , Anisaquíase/sangue , Anisaquíase/imunologia , Anisaquíase/fisiopatologia , Anisakis/crescimento & desenvolvimento , Anisakis/patogenicidade , Ingestão de Alimentos , Endoscopia Gastrointestinal , Eritema , Feminino , Mucosa Gástrica/parasitologia , Mucosa Gástrica/patologia , Humanos , Imunoglobulina E/sangue , Prurido
11.
J Investig Allergol Clin Immunol ; 19(6): 446-52, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20128418

RESUMO

BACKGROUND: We investigated the usefulness of the bronchial challenge (BC) with lysine-acetylsalicylate (L-ASA) in the diagnosis of aspirin-exacerbated respiratory disease (AERD) using a protocol that combined both the oral challenge (OC) and the BC tests. METHODS: Adult asthmatic patients with suspected AERD who underwent BC with L-ASA were included in the study. If the BC result with L-ASA was negative, an OC was carried out to establish the diagnosis. AERD was ruled out if both the BC and the OC results were negative (nonresponders). Both responders and nonresponders were compared for age, gender, a personal or family history of atopy, underlying disease, current asthma treatment, and presence of nasal polyps. Six patients with asthma but no suggestive history of AERD were included as controls. RESULTS: Twenty-two patients completed the study. Ten patients tested positive to the BC and/or OC (responders), whereas 12 did not (nonresponders). Seven out of the 10 responders had a positive BC result and 3 a positive OC result. After BC, 4 patients had an early asthmatic response, 1 had a dual response, and 2 had isolated late responses. No significant differences were observed in the aforementioned variables between responders and nonresponders. The results of both challenges were negative in the 6 controls. CONCLUSIONS: The BC had a high positive predictive value, was safe, and when negative, the subsequent OC did not result in any severe adverse reactions. The BC elicited an isolated late asthmatic response that has not been previously described in the literature.


Assuntos
Alérgenos/administração & dosagem , Aspirina/análogos & derivados , Asma Induzida por Aspirina/diagnóstico , Testes de Provocação Brônquica , Imunização , Lisina/análogos & derivados , Administração Oral , Adulto , Alérgenos/efeitos adversos , Alérgenos/imunologia , Aspirina/administração & dosagem , Aspirina/efeitos adversos , Aspirina/imunologia , Asma Induzida por Aspirina/fisiopatologia , Estudos Transversais , Progressão da Doença , Feminino , Humanos , Lisina/administração & dosagem , Lisina/efeitos adversos , Lisina/imunologia , Masculino , Pessoa de Meia-Idade , Pólipos Nasais , Projetos Piloto , Valor Preditivo dos Testes
14.
Artigo em Inglês | MEDLINE | ID: mdl-17583101

RESUMO

OBJECTIVE: To determinate the existence of associations among sensitizations to antigens produced by pollen grains of different botanical species as assessed by skin prick tests in patients with respiratory disorders. METHODS: Six hundred twenty nine consecutive patients living in the northern area of Madrid who underwent clinical evaluation because of rhinoconjunctivitis, and/or asthma were studied. All patients were tested with a skin prick test using a battery of inhalants including pollens, dust mites, molds and danders. The exploratory multivariate technique of Multiple Correspondence Analysis was used to compare the homogeneity of sensitizations between groups. Of the 629 patients, 459 (73.0%) had positive skin prick tests to pollen and were selected as the study group. RESULTS: The most prevalent pollen sensitization was to Gramineae pollen (83.7%) followed by Oleaceae sensitisation (75.8%). Multiple Correspondence Analysis revealed the existence of an association among pollen sensitizations, showing that they clustered two groups: sensitizations to Gramineae, Oleaceae, Cupressaceae, Chenopodiaceae, Plantaginaceae (group I), and sensitizations to Betulaceae, Platanaceae, Compositae (group II). Sensitization to Parietaria was not included in any of the sensitization groups and showed an independent behaviour. CONCLUSION: Pollen sensitizations in our area cluster into two association groups which have not previously been reported.


Assuntos
Hipersensibilidade/epidemiologia , Plantas/efeitos adversos , Pólen/efeitos adversos , Adolescente , Adulto , Idoso , Asteraceae/efeitos adversos , Asteraceae/imunologia , Betulaceae/efeitos adversos , Betulaceae/imunologia , Chenopodiaceae/efeitos adversos , Chenopodiaceae/imunologia , Criança , Pré-Escolar , Cupressaceae/efeitos adversos , Cupressaceae/imunologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oleaceae/efeitos adversos , Oleaceae/imunologia , Parietaria/efeitos adversos , Parietaria/imunologia , Plantago/efeitos adversos , Plantago/imunologia , Plantas/imunologia , Poaceae/efeitos adversos , Poaceae/imunologia , Testes Cutâneos , Espanha/epidemiologia
17.
Allergy ; 57(3): 254-7, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11906341

RESUMO

BACKGROUND: Thiomucase is a mucopolysaccharidase obtained from ovine tissues mainly used to facilitate the diffusion of local anaesthetics and in the treatment of cellulitis. A patient with an anaphylaxis in relation to the intramuscular administration of Thiomucase is reported. OBJECTIVE: To investigate Thiomucase allergens and their possible relationship with dander allergens and animal albumins. MATERIAL AND METHODS: Skin prick tests (SPT) and serum-specific IgE were performed with Thiomucase and danders. Thiomucase SDS-PAGE immunoblotting was performed in order to study allergens. RAST/CAP inhibition and SDS-PAGE immunoblotting inhibition were carried out to study the cross-reactivity. RESULTS: Skin prick tests (SPT) were positive to Thiomucase, animal dander (cat, dog, sheep, other), bovine serum albumin (BSA), and echinococcus. Specific IgE was also positive to Thiomucase, animal dander (cat, dog, sheep, other), BSA and echinococcus. In the RAST-CAP inhibition assays BSA was nearly completely inhibited by Thiomucase, Thiomucase was partially inhibited by BSA and cat and Echinococcus granulosus was partially inhibited by sheep and Thiomucase. In the Thiomucase SDS-PAGE immunoblotting several proteins fixed IgE, ranging from 20 kDa to > 94 kDa, the strongest with 43 kDa. The IgE fixation to BSA, cat and sheep in the SDS-PAGE immunoblotting was completely inhibited by the preincubation of the serum with Thiomucase. CONCLUSIONS: An IgE-mediated anaphylaxis to Thiomucase is documented. Multiple allergens are recognized in Thiomucase by the patient serum, the main with 43 kDa. Partial cross-reactivity with BSA, cat dander and sheep dander is documented.


Assuntos
Anafilaxia/etiologia , Glucuronidase/imunologia , Imunoglobulina E/imunologia , Liases/imunologia , Reações Cruzadas , Humanos , Peso Molecular
18.
Artigo em Inglês | MEDLINE | ID: mdl-10879993

RESUMO

Different allergenic proteins have been involved in cross-reactivity among animals. Albumins seem to be cross-sensitizing allergenic components. The aim of this study was to assess the importance of albumin as a cross-reactive allergen in patients sensitized to cat, dog and horse. One hundred and seventeen patients sensitized to cat were tested for IgE reactivity using skin prick tests and RAST assays with cat, dog and horse hair/dander extracts and their purified albumin extracts. RAST-inhibition studies were carried out to assess cross-reactivity among cat, dog and horse and among their purified albumins. It was found that 22% of patients exhibited specific IgE to cat albumin; 41% of patients sensitized to cat were also sensitized to dog and horse. Out of these patients, 21% had IgE to three albumins and 17% to two. Reciprocal inhibitions were observed among cat, dog and horse albumins and also among cat, dog and horse hair/dander extracts, using in the latter experiment sera from patients not sensitized to albumins. IgE binding to horse extract was inhibited 30% by its homologous albumin and IgE binding to cat and dog extracts in almost 15% by their respective albumins. It was concluded that albumins from these three animals share some epitopes that account for the cross-reactivity observed in around one-third of patients sensitized to cat, dog and horse. Nevertheless, more than 50% of specific IgE that cross-reacts among these three animals is directed to allergens other than albumin.


Assuntos
Albuminas/efeitos adversos , Alérgenos/efeitos adversos , Alérgenos/imunologia , Gatos/imunologia , Cães/imunologia , Cavalos/imunologia , Hipersensibilidade Imediata/etiologia , Albuminas/imunologia , Animais , Asma/etiologia , Asma/imunologia , Conjuntivite Alérgica/etiologia , Conjuntivite Alérgica/imunologia , Reações Cruzadas , Cabelo/imunologia , Humanos , Hipersensibilidade Imediata/sangue , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Testes Intradérmicos , Teste de Radioalergoadsorção , Rinite Alérgica Perene/etiologia , Rinite Alérgica Perene/imunologia , Pele/imunologia , Extratos de Tecidos/imunologia
20.
J Gastroenterol Hepatol ; 15(5): 503-6, 2000 May.
Artigo em Inglês | MEDLINE | ID: mdl-10847436

RESUMO

BACKGROUND AND AIMS: Ingestion of Anisakidae larvae in raw seafood may cause anisakiasis. However, despite the high level of consumption of seafood in Spain, only a few cases of anisakiasis have been reported until now. Anisakis simplex can cause allergic reactions in sensitized patients as a result of its parasitism in the gastrointestinal tract. The purpose of this study was to analyse the clinical findings in 22 patients with gastroallergic anisakiasis. METHODS: Patients with allergic and/or gastric symptoms after seafood ingestion were evaluated in the emergency room of the La Paz General University Hospital. Skin testing for Anisakis simplex and tests on the implicated seafood were performed and amounts of serum-specific immunoglobulin E were assessed. A gastroscopy was performed in those patients with severe allergic or/and persistent gastric symptoms after ingestion of raw or undercooked seafood. RESULTS: Twenty-two patients were diagnosed with gastroallergic anisakiasis in 1 year. Most patients presented to the emergency room of our hospital with allergic symptoms. Gastric symptoms were usually moderate. Gastroscopy revealed local mucosal oedema and gastric erosion at the point of fixation. Two or more worms were detected in three patients. The mean time of latency of allergic symptoms was 5 h, while the mean time for gastric symptoms was 3 h. CONCLUSION: Anisakis simplex parasitism was the causative agent of allergic and gastric symptoms. Gastroallergic anisakiasis appears to be a relatively common disease, that may have been underdiagnosed.


Assuntos
Anisaquíase/imunologia , Anisakis/imunologia , Gastrite/parasitologia , Hipersensibilidade/parasitologia , Adolescente , Adulto , Idoso , Animais , Anisaquíase/prevenção & controle , Anisakis/isolamento & purificação , Serviço Hospitalar de Emergência , Feminino , Gastrite/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Espanha
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