[Lower limb paresis after total hip arthroplasty. A rare differential diagnosis]. / Beinparese nach Hüftendoprothesenimplantation. Eine seltene Differenzialdiagnose.

We report on a case of complex nerve damage during total hip arthroplasty. The most severe clinical symptom was proximal leg paresis with diffuse sensory loss. There was an extensive causal Iliopsoas hematoma which developed during the postoperative rehabilitation under therapeutic anticoagulation for atrial fibrillation. An iliopsoas hematoma with subsequent neurological deficits are rare events in the field of hip arthroplasty and a literature review is provided. The treatment of retroperitoneal hemorrhage is controversial but in most instances a conservative approach is favored. The prognosis of neurological damage is sobering as only 20 % of victims are expected to achieve complete restitution.

[Instruments of management accounting in german hospitals - potentials for competitive advantage and status quo]. / Der Einsatz von Controllinginstrumenten in Krankenhäusern - Erfolgspotenziale und Status quo.

AIM: The aim of this study is to provide an analysis of the status quo for the usage of instruments of management accounting in German hospitals. METHODS: 600 managing directors of German hospitals were asked to answer a questionnaire about the usage of management accounting instruments in their hospitals. We obtained 121 usable datasets, which are evaluated in this study. RESULTS: A significant increase in the usage of management accounting instruments can be observed over time. The respondents have an overall positive perception of the usage of these instruments. Cost accounting and information systems are among the most widely used instruments, while widely discussed concepts like the balanced scorecard or clinical pathways show surprisingly low usage rates.

Ant aggression and evolutionary stability in plant-ant and plant-pollinator mutualistic interactions.

Mutualistic partners derive a benefit from their interaction, but this benefit can come at a cost. This is the case for plant-ant and plant-pollinator mutualistic associations. In exchange for protection from herbivores provided by the resident ants, plants supply various kinds of resources or nests to the ants. Most ant-myrmecophyte mutualisms are horizontally transmitted, and therefore, partners share an interest in growth but not in reproduction. This lack of alignment in fitness interests between plants and ants drives a conflict between them: ants can attack pollinators that cross-fertilize the host plants. Using a mathematical model, we define a threshold in ant aggressiveness determining pollinator survival or elimination on the host plant. In our model we observed that, all else being equal, facultative interactions result in pollinator extinction for lower levels of ant aggressiveness than obligatory interactions. We propose that the capacity to discriminate pollinators from herbivores should not often evolve in ants, and when it does it will be when the plants exhibit limited dispersal in an environment that is not seed saturated so that each seed produced can effectively generate a new offspring or if ants acquire an extra benefit from pollination (e.g. if ants eat fruit). We suggest specific mutualism examples where these hypotheses can be tested empirically.

Cost and conflict in animal signals and human language.

The "costly signaling" hypothesis proposes that animal signals are kept honest by appropriate signal costs. We show that to the contrary, signal cost is unnecessary for honest signaling even when interests conflict. We illustrate this principle by constructing examples of cost-free signaling equilibria for the two paradigmatic signaling games of Grafen (1990) and Godfray (1991). Our findings may explain why some animal signals use cost to ensure honesty whereas others do not and suggest that empirical tests of the signaling hypothesis should focus not on equilibrium cost but, rather, on the cost of deviation from equilibrium. We use these results to apply costly signaling theory to the low-cost signals that make up human language. Recent game theoretic models have shown that several key features of language could plausibly arise and be maintained by natural selection when individuals have coincident interests. In real societies, however, individuals do not have fully coincident interests. We show that coincident interests are not a prerequisite for linguistic communication, and find that many of the results derived previously can be expected also under more realistic models of society.

On the dynamic persistence of cooperation: how lower individual fitness induces higher survivability.

We study a model in which cooperation and defection coexist in a dynamical steady state. In our model, subpopulations of cooperators and defectors inhabit sites on a lattice. The interactions among the individuals at a site, in the form of a prisoner's dilemma (PD) game, determine their fitnesses. The chosen PD payoff allows cooperators, but not defectors, to maintain a homogeneous population. Individuals mutate between types and migrate to neighboring sites with low probabilities. We consider both density-dependent and density-independent versions of the model. The persistence of cooperation in this model can be explained in terms of the life cycle of a population at a site. This life cycle starts when one cooperator establishes a population. Then defectors invade and eventually take over, resulting finally in the death of the population. During this life cycle, single cooperators migrate to empty neighboring sites to found new cooperator populations. The system can reach a steady state where cooperation prevails if the global "birth" rate of populations is equal to their global "death" rate. The dynamic persistence of cooperation ranges over a large section of the model's parameter space. We compare these dynamics to those from other models for the persistence of altruism and to predator-prey models.

On the advantages of information sharing.

During the evolution of life, there have been several transitions in which individuals began to cooperate, forming higher levels of organization, and sometimes losing their independent reproductive identity For example, multicellularity and insect societies evolved independently multiple times. Several factors that confer evolutionary advantages on higher levels of organization have been proposed. In this paper we highlight one additional factor: the sharing of information between individuals. Information sharing is not subject to the intrinsic conservation laws that characterize the sharing of physical resources. A simple model will illustrate how information sharing can result in aggregates in which the individuals both receive more information about their environment and pay less for it. This may have played a role in the evolution of higher levels of organization.

Adopting adoption.

The common occurrence of adoption among birds and mammals presents evolutionary biologists with an explanatory challenge. The benefits to adoptees are self-evident, but the benefits to the adopter(s), the origin of the set of behaviours that constitute 'adoptive' behaviour, and the conditions for its spread in populations are not always clear. Explanations in terms of direct and indirect benefits to adopters and adoptees, and in terms of conflict between them have been suggested to account for the current functions and the evolutionary origin of 'adoptive' behaviour. In this paper we emphasize one aspect of the parenting behaviour associated with adoption that has been neglected: we suggest that adoption in birds and mammals is a route for the transfer of learnt information through social learning of patterns of behaviour, including styles of parenting. By using simple models we show that learning parenting from non-parents may provide additional opportunities for the spread of the 'adoptive' behaviour itself, even when it has no selective advantage. We also offer an additional explanation for the adaptive significance of adoption for both adopters and adoptees. Our 'match-making' hypothesis suggests that in some cases, by adopting foreign young, parents provide their genetic young with future ecologically compatible, but genetically unrelated, mates. Copyright 1998 The Association for the Study of Animal Behaviour. Copyright 1998 The Association for the Study of Animal Behaviour.

Signalling among relatives. II. Beyond the tower of Babel.

Models of costly signalling are commonly employed in evolutionary biology in order to explain how honest communication between individuals with conflicting interests can be stable. These models have focused primarily on a single type of honest signalling equilibrium, the separating equilibrium in which any two different signallers send distinct signals, thereby providing signal receivers with complete information. In this paper, we demonstrate that in signalling among relatives (modelled using the Sir Philip Sidney game), there is not one but a large number of possible signalling equilibria, most of which are pooling equilibria in which different types of signallers may share a common signal. We prove that in a general Sir Philip Sidney game, any partition of signallers into equi-signalling classes can have a stable signalling equilibrium if and only if it is a contiguous partition, and provide examples of such partitions. A similar (but slightly stricter) condition is shown to hold when signals are transmitted through a medium with signalling error. These results suggest a solution to a problem faced by previous signalling theory models: when we consider the separating equilibrium, signal cost is independent of the frequency of individuals sending that signal and, consequently, even very rare signaller types can drastically affect signal cost. Here, we show that by allowing these rare signallers to pool with more common signallers, signal cost can be greatly reduced.

Signaling among relatives. III. Talk is cheap.

The Sir Philip Sidney game has been used by numerous authors to show how signal cost can facilitate honest signaling among relatives. Here, we demonstrate that, in this game, honest cost-free signals are possible as well, under very general conditions. Moreover, these cost-free signals are better for all participants than the previously explored alternatives. Recent empirical evidence suggests that begging is energetically inexpensive for nestling birds; this finding led some researchers to question the applicability of the costly signaling framework to nestling begging. Our results show that cost-free or inexpensive signals, as observed empirically, fall within the framework of signaling theory.

The inheritance of phenotypes: an adaptation to fluctuating environments.

We discuss simple models for the evolution of rates of spontaneous and induced heritable phenotypic variations in a periodically fluctuating environment with a cycle length between two and 100 generations. For the simplest case, the optimal spontaneous transition rate between two states is approximately 1/n (where n is the cycle length). It is also shown that selection for the optimal transition rate under these conditions is surprisingly strong. When n is small, this means that the heritable variations are produced by non-classical inheritance systems, including non-DNA inheritance systems. Thus, it is predicted that in genes controlling adaptation to such environments, non-classical genetic effects are likely to be observed. We argue that the evolution of spontaneous and induced heritable transitions played an important role in the evolution of ontogenies of both unicellular and multicellular organisms. The existence of a machinery for producing induced heritable phenotypic variations introduces a "Lamarckian" factor into evolution.

Influence of formycin B on polyadenosine diphosphoribose synthesis in vitro and in vivo.

Formycin B inhibited growth of L5178Y mouse leukemia cells in concentrations of less than twice the concentration that inhibits cell proliferation at 50% by cytostasis; at higher concentrations (more than twice the 50% concentration mentioned), the cells were killed. In cells treated with the concentration that inhibits cell proliferation at 50%, the average cell volume did not change. The formycin B inhibitory effect on cell proliferation was reduced by coincubation with nicotinamide adenine diphosphate or adenosine. The biosyntheses of DNA,RNA, and protein in whole cells were sensitively inhibited by formycin B as checked by incorporation studies with radioactive precursors. In addition, the formation of polyadenosine diphosphoribose was reduced even with higher sensitivity; in particular the extent of adenosine diphosphate ribosylation of histone subfraction H1 was reduced. Formycin B has been shown to be an inhibitor for the polyadenosine diphosphoribose polymerase, isolated from oviduct nuclei of quails. Both the chromatin-bound and the soluble enzyme are inhibited competitively; the relative affinity (Ki/Km) of formycin B to the polyadenosine diphosphoribose polymerase is 1.5.

Mode of action of 9-beta-D-arabinofuranosyladenine on the synthesis of DNA, RNA, and protein in vivo and in vitro.

The influence of 9-beta-D-arabinofuranosyladenine (ara-A) and its 5'-triphosphate derivative on programmed synthesis was tested with an intact cell system as well as with isolated enzyme systems. The effect of ara-A was tested in mouse lymphoma cells (L5178Y). The compound reduces cell proliferation in low concentration by cytostasis; under high ara-A concentration of radioactive precursors into DNA, RNA, and protein showed that ara-A selectively inhibits DNA synthesis. Formation of a polysome complex is not affected by ara-A. [3H]ara-A is incorporated into DNA in an intact cell system; 1 molecule of ara-A is incorporated per 8000 molecules of deoxyadenosine. Most of the ara-A molecules appeared to be in internucleotide linkages. Incorporation of ara-A into RNA could not be detected. 9-BETA-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) does not reduce the incorporation rate of the following enzymes, isolated from quail oviducts: DNA-dependent RNA polymerases I and II, polyadenylic acid polymerase, and poly(adenosine diphosphate ribose) polymerase. The compound was found to inhibit DNA synthesis catalyzed by DNA polymerases isolated from quail oviducts and from oncogenic RNA viruses (Rous sarcoma viruses). All the enzymes tested were inhibited by ara-ATP in a competitive way with respect to deoxyadenosine 5'-triphosphate. The highest affinity of ara-ATP, i.e., the highest inhibitory potency of the drug, was found in the assays with the eukaryotic low-molecular DNA-dependent DNA polymerase. The influence on the eukaryotic high-molecular DNA-dependent Dna polymerase was a litte less. Compared to the eukaryotic DNA polymerases, the viral enzymes (RNA-directed DNA polymerase and DNA-directed DNA polymerase) are affected to a smaller extent by ara-ATP. No effects of ara-A and ara-ATP are observed in a protein-synthesizing, cell-free system isolated from L5178Y cells.