RESUMO
Homeobox genes play an important role in the regulation of early embryonic development. They represent a family of evolutionarily highly conserved transcription factors. In this work, several genes that belong to the four HOX gene clusters are assigned by in situ hybridization to four distinct chicken chromosomes. The four gene clusters are mapped to 2p2.1 (HOXA), 3q3.1 (HOXB), 1q3.1 (HOXC) and 7q1.3--> q1.4 (HOXD). We confirm partial homologies already detected by genetic mapping between chicken chromosomes 1, 2 and 7 and human chromosomes 12, 7 and 2 and we describe a new conserved segment between chicken chromosome 3 and human chromosome 17. These results represent the first data that confirm the physical linkage between chicken HOX genes and may improve our understanding of phylogenetic relationships and genome evolution.
Assuntos
Galinhas/genética , Cromossomos Humanos Par 17/genética , Sequência Conservada/genética , Genes Homeobox/genética , Genoma , Mapeamento Físico do Cromossomo , Animais , Células Cultivadas , Embrião de Galinha , Bandeamento Cromossômico , Evolução Molecular , Fibroblastos , Humanos , Hibridização in Situ Fluorescente , Camundongos , Família Multigênica/genética , Filogenia , Homologia de Sequência do Ácido Nucleico , Suínos/genéticaAssuntos
Galinhas/genética , Cromossomos/genética , Genes/genética , Genoma , Mapeamento Físico do Cromossomo , Animais , Sequência de Bases , Clonagem Molecular , Bases de Dados como Assunto , Evolução Molecular , Humanos , Longevidade , Polimorfismo de Nucleotídeo Único/genética , Recombinação Genética , Telômero/genéticaRESUMO
The chicken genetic map is becoming very detailed. The genetic and physical maps need to be integrated in more detail. It is important to have a consensus banded karotype to permit this integration. An international committee met to develop a karyotype for the eight largest chromosomes and the Z and W chromosomes of the domestic fowl (Gallus domesticus). This map is presented in this report.