RESUMO
Controlled drug release via electrical stimulation from drug-impregnated fibres was studied using electrospun cellulose acetate (CA) membranes and encapsulated ibuprofen (IBU). This research outlines the influence of polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT)-functionalised CA membranes and their suitability for dermal electronic-controlled drug release. Micro Raman analysis confirmed polymer functionalisation of CA membranes and drug incorporation. Scanning electron microscopy (SEM) images evidenced the presence of PPy and PEDOT coatings. The kinetic of drug release was analysed, and the passive and active release was compared. In the proposed systems, the drug release is controlled by very low electrical potentials. A potential of -0.3 V applied to membranes showed the ibuprofen retention, and a positive potential of +0.3 V, +0.5 V, or +0.8 V, depending on the conductive polymer and membrane configuration, enhanced the drug release. A small adhesive patch was constructed to validate this system for cutaneous application and verified an "ON/OFF" ibuprofen release pattern from membranes.
RESUMO
Exame das mamas e inspeção externa da genitália devem ser considerados componentes essenciais na visita de supervisão para a saúde regular do adolescente e meninas pelo pediatra. A anamnese ginecológica inclui questões relativas ao examinador e ao paciente. Alguns achados no exame da genitália externa incluem: fusão dos lábios, hímem imperfurado, sinais de trauma e vulvovaginites. Este artigo tem como objetivo revisar estes sintomas e sinais e seus tratamentos específicos.