Assuntos
Anticorpos Monoclonais/uso terapêutico , Autoanticorpos/sangue , Fator VIII/imunologia , Hemofilia A/tratamento farmacológico , Adulto , Idoso , Anticorpos Monoclonais Murinos , Formação de Anticorpos , Feminino , Hemofilia A/etiologia , Hemorragia/etiologia , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Rituximab , Trombose/etiologiaRESUMO
Fanconi's anemia (FA) is rare autosomal recessive disorder characterized by aplastic anemia, congenital anomalies, and cancer susceptibility. FA patients have deficiencies in DNA repair pathways that cause cellular sensitivity to ionizing radiation and cross-link agents such as mitomycin C and diepoxybutane (DEB). If these patients survive until early adulthood, they are at high risk for developing solid tumors, most commonly squamous cell carcinoma of the oropharynx, esophagus, and vulva. Treatment of these solid tumors with radiotherapy is complicated by the increased risk of normal tissue toxicity. Three-dimensional (3D) conformal radiotherapy is a technique that uses CT images to more accurately target tumors and maximize the dose to the tumor volume while limiting the dose to normal tissue. This report describes application of 3D conformal radiotherapy techniques to the treatment of vulvar cancer in a patient with FA in an attempt to limit the normal tissue volume exposed to radiation.
Assuntos
Anemia de Fanconi/complicações , Radioterapia Conformacional , Neoplasias Vulvares/radioterapia , Adulto , Feminino , Humanos , Neoplasias Vulvares/patologiaRESUMO
Primary mediastinal large B-cell lymphoma (PMLBCL) is a distinct disease entity that has a relatively short history. The prognosis and therapy of patients with PMLBCL is still controversial. We summarize our experience with PMLBCL at the Medical University of South Carolina between 1997 and 2000.