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1.
Int J Occup Med Environ Health ; 37(1): 3-17, 2024 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-38323457

RESUMO

The aim was to evaluate if rehabilitation procedures including occupational health (OH) and workplace participation increase return to work (RTW) rates among patients with subacute and chronic low back pain (LBP). A systematic review of randomized controlled trials was conducted using the PubMed and Cochrane databases. Main outcomes were RTW and days of sick leave. Interventions needed to be multidisciplinary including both OH and active workplace involvement in rehabilitation. Out of 1073 potentially eligible references, 8 met the inclusion criteria. Three studies had OH and 5 case managers involved in rehabilitation. Rehabilitation involving both OH and workplace improved RTW and decreased the number of sick leave days among LBP patients. Having case managers involved had no effect in RTW. In order to improve RTW, workplace visits and work ability meetings (WAMs) between OH and workplace are essential components in the rehabilitation process among patients with chronic LBP. Based on the study results, the authors suggest utilizing these co-operative interventions with workplaces in OH. High quality research investigating only the effect of WAMs in OH setting is needed in future. Int J Occup Med Environ Health. 2024;37(1):3-17.


Assuntos
Dor Lombar , Saúde Ocupacional , Humanos , Emprego , Dor Lombar/reabilitação , Retorno ao Trabalho , Licença Médica , Local de Trabalho , Ensaios Clínicos Controlados Aleatórios como Assunto
2.
Work ; 78(2): 419-430, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38160385

RESUMO

BACKGROUND: Promoting health is an important part of occupational health (OH) professionals' daily practice. Occupational health services (OHS) support work ability and prevent both work-related diseases and lifestyle-related illnesses. OBJECTIVE: We focused on how interprofessional collaboration (IPC), regardless of whether the OHS provider is public, private or in-house, influences the implementation of smoking cessation treatment and support (SCTS). We studied IPC of OH professionals in SCTS and whether they differ depending on OHS providers. METHODS: We collected data through an online survey of a cross-sectional sample of OH professionals of physicians (n = 182), nurses (n = 296) and physiotherapists (n = 96) at two different time-points, in 2013 and 2017. The questionnaire contained questions on interprofessional SCTS practices, so that we could assess how the professionals' experiences differed from each other. We used explanatory factor analysis to study the collaboration, and the Kruskall-Wallis test to detect the differences between the OH professional groups as a post-hoc data analysis. Background: OH physicians (mean 3.4, SD 1.2) and OH nurses (mean 3.2, SD 1.1) experienced smooth collaboration in SCTS whereas OH physiotherapists (mean 2.5, SD 1.1) felt excluded from IPC. In-house OH centres (mean 3.5, SD 1.0) seemed to offer the best opportunities for implementing IPC in SCTS comparing to public (mean 3.1, SD 0.9) or private (mean 2.9, SD 0.9) OHS. CONCLUSION: The IPC of OH professionals in SCTS interventions need to be rearranged. This requires boundary-crossing SCTS practices involving all professionals. All OH professionals should implement IPC in SCTS and share their specific competence.


Assuntos
Comportamento Cooperativo , Abandono do Hábito de Fumar , Humanos , Estudos Transversais , Abandono do Hábito de Fumar/métodos , Abandono do Hábito de Fumar/psicologia , Inquéritos e Questionários , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Relações Interprofissionais , Serviços de Saúde do Trabalhador/métodos
3.
Int Arch Occup Environ Health ; 94(4): 689-697, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33389081

RESUMO

PURPOSE: A work disability negotiation takes place between a supervisor, the disabled employee and the occupational health service (OHS) to support the disabled employee in returning to their work, often with temporary work accommodation. The objective of this study was to define the factors of a work disability negotiation with OHS that supported or hindered supervisors in their task/role in work disability management. METHODS: The study setting comprised two parts: the creation of survey questions and the actual survey of supervisors (N = 254) from six public and private organizations in Finland. Of these, 133 (52%) had participated in one or more work disability negotiations. The responses covered about 240 work disability cases and considerably more negotiations. RESULTS: The study identified four key elements that the supervisors expressed as major success factors in the negotiations. First, it was crucial that the supervisors learned about the employee's health restrictions and understood the issues relating to their work disability. Second, the parties should aim for common solutions and conclusions through collaboration. Third, active participation of all the negotiation parties is important. The supervisors gave a high rating to OHS taking their views seriously. Last, the supervisors appreciated collaboration in a constructive atmosphere. CONCLUSION: In order for a negotiation to help supervisors in their challenges, it should reach solutions, conclusions and a restructured comprehension of the work disability problem in a constructive atmosphere and with active communication between stakeholders.


Assuntos
Avaliação da Deficiência , Pessoas com Deficiência/psicologia , Relações Interprofissionais , Negociação/psicologia , Retorno ao Trabalho , Adulto , Feminino , Finlândia , Humanos , Masculino , Pessoa de Meia-Idade , Serviços de Saúde do Trabalhador , Organização e Administração , Inquéritos e Questionários
4.
J Occup Health ; 62(1): e12145, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32701202

RESUMO

OBJECTIVES: Occupational health (OH) professionals could play a prominent role in smoking cessation treatment and support (SCTS) and help individuals and workplaces become smoke free. However, their role has not been evaluated. The aim of this study was to assess differences between OH professionals' perceptions of their role in SCTS by measuring three groups of OH professionals' attitudes, knowledge, and motivation concerning SCTS. METHODS: We collected data through an online survey completed by a cross-sectional sample of OH professionals: OH physicians (n = 182), OH nurses (n = 296), and OH physiotherapists (n = 96), collected from national trade union registers. The differences between the OH professional groups were analyzed using ANOVA, the Kruskal-Wallis, and chi-square tests. RESULTS: The OH professionals had a positive attitude toward offering SCTS and were highly motivated to enhance their knowledge of this topic and acquire further training. The OH physicians and OH nurses assessed their current knowledge as sufficient. Conversely, the OH physiotherapists' level of knowledge was seen as insufficient. Traditionally, OH physicians and OH nurses have been responsible for carrying out SCTS, but the majority of the OH physiotherapists thought that SCTS should also be included in their job description. CONCLUSIONS: All the OH professionals were highly motivated to deepen their knowledge of SCTS. The barriers between different professionals need to be recognized in occupational health services (OHS). OHS should organize its SCTS more effectively, strengthen their contributions to smoking cessation programs, and recognize the potential of OH physiotherapists for providing SCTS and enable them to expand their training.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Pessoal de Saúde/psicologia , Motivação , Saúde Ocupacional , Abandono do Hábito de Fumar , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
5.
Disabil Rehabil ; 41(17): 2015-2025, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-29587552

RESUMO

Purpose: To introduce the Finnish practice of collaboration aiming to enhance work participation, to ask supervisors about its reasons and usefulness, to study supervisors' needs when they face work disability, and to compare the experiences of supervisors whose profiles differ. Materials and methods: An online questionnaire based on the Finnish practice of collaboration between supervisor and occupational health services (OHS) went to supervisors in six public and private organizations. A total of 254 supervisors responded, of whom, 133 (52%) had collaborated in work disability negotiations, representing a wide variety with differing professional profiles. Results: In their role of managing work disability, supervisors appeared to benefit from three factors: an explicit company disability management (DM) policy, supervisors' training in DM, and collaboration with OHS. Reasons for work disability negotiations were long or repeated sick-leaves and reduced work performance. Expectations for occupational health consultations focused on finding vocational solutions and on obtaining information. Supervisors assessed the outcomes of collaboration as both vocational and medical. Supervisors with differing professional profiles prioritized slightly different aspects in collaboration. Conclusions: Collaboration with OHS is an important option for supervisors to enhance work modifications and the work participation of employees with work disability. Implications for Rehabilitation Work disability negotiation between supervisor, employee, and occupational health services (OHS) is an effective method to enhance work participation. Collaboration with occupational health can advance work modifications and also lead to medical procedures to improve work performance. Supervisor training, companies' explicit disability management policy, and collaboration with OHSs all advance employee's work participation. Collaboration with OHSs may serve as training for supervisors in their responsibility to support work participation.


Assuntos
Pessoal Administrativo , Pessoas com Deficiência , Negociação , Serviços de Saúde do Trabalhador , Avaliação da Capacidade de Trabalho , Finlândia , Humanos , Gestão de Recursos Humanos , Retorno ao Trabalho , Licença Médica , Inquéritos e Questionários
6.
J Occup Environ Med ; 55(2): 191-7, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23364212

RESUMO

OBJECTIVE: To study associations between psychosocial work factors (PWF) and sick leave, occupational accident, and disability pension. METHODS: A random population of 967 civil servants participated in a survey on PWF and health. The median follow-up time was 7 years. RESULTS: Frequent feedback from supervisor, good opportunities for mental growth, good team climate, and high appreciation were associated with a decrease in the risk of sickness absences and shift/period work, monotonous movements, and crowdedness of workplace were associated with an increase in the risk of sickness absences. Good communication at work was associated with a decrease in client violence and high work pressure was associated with an increased risk of occupational accidents. High work control and good team climate were associated with a decreased and shift/period work and client violence was associated with an increased risk of disability pensions. CONCLUSIONS: Psychosocial work factors can predict health outcomes with economic impact.


Assuntos
Acidentes de Trabalho/psicologia , Pessoas com Deficiência/psicologia , Emprego/psicologia , Licença Médica , Trabalho/psicologia , Adulto , Idoso , Comunicação , Comportamento Cooperativo , Retroalimentação , Feminino , Finlândia , Humanos , Satisfação no Emprego , Masculino , Pessoa de Meia-Idade , Cultura Organizacional , Aposentadoria , Fatores de Risco , Estresse Psicológico/complicações , Local de Trabalho/organização & administração , Local de Trabalho/psicologia , Adulto Jovem
7.
Cancer Epidemiol ; 36(5): 421-4, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22683172

RESUMO

BACKGROUND: Statins (HMG-CoA-reductase inhibitors) are suggested to act as a predisposing factor for autoimmune diseases, have immunomodulatory effects, and possibly prevent some cancer types - the sum of these effects is unknown in cancers of viral aetiology, such as Merkel cell carcinoma (MCC). Aim of our study was to find out whether statin users in Finland have an increased incidence of MCC. PATIENTS AND METHODS: A cohort of 224715 male and 230220 female statin users during 1994-2007 was identified from the Prescription Register of the National Social Insurance Institution. This cohort was followed up through the Finnish Cancer Registry for MCC up to 2009. RESULTS: There were altogether 50 cases of MCCs, while the expected number of cases, calculated on the basis of the MCC incidence in comparable Finnish population, was 39.9 (SIR 1.25, 95% CI 0.93-1.65). The standardized incidence ratio (SIR) for MCC in ages <60 years was 3.16 (95% CI 0.65-9.23), in ages 60-74 years 1.94 (95% CI 1.23-2.90) and in ages ≥75 years 0.89 (95% CI 0.57-1.31). The relative risk of MCC decreased significantly, 0.79 fold (95% CI 0.67-0.92), at each 5 year step when moving towards older age groups. There was no significant variation in SIR related to years since starting the statin use, or between the genders. CONCLUSIONS: MCC is the first neuroendocrine cancer linked to statin use. The association is statistically significant and biologically plausible through immunomodulatory effects of statins. The excess of MCCs was observed in atypically young patients, a similar phenomenon as noted earlier in patients with immunocompromising states.


Assuntos
Carcinoma de Célula de Merkel/epidemiologia , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Fatores Imunológicos/efeitos adversos , Neoplasias Cutâneas/epidemiologia , Idoso , Causalidade , Estudos de Coortes , Intervalos de Confiança , Feminino , Finlândia/epidemiologia , Seguimentos , Humanos , Incidência , Masculino , Registro Médico Coordenado , Pessoa de Meia-Idade , Vigilância da População , Medição de Risco , Programa de SEER
8.
J Rehabil Med ; 44(8): 669-76, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22729795

RESUMO

OBJECTIVE: The aim of this study was to determine how employee well-being, psychosocial factors at work, leadership and perceived occupational health services predict entering rehabilitation as modelled in the Job Well-being Pyramid. METHODS: A random population of 967 civil servants participated in a survey on psychosocial factors and health at work in 2000 in Finland. A total of 147 employees entered rehabilitation during the median follow-up time of 7 years. RESULTS: Permanent employment, large organizations, feedback from supervisors, client violence and physically monotonous work were associated with an increased rate of entering rehabilitation, whereas physical jobs, clear aims, high appreciation, job satisfaction and job enjoyment were associated with a decreased rate of entering rehabilitation. Employee well-being in general was also associated with entering rehabilitation, and this was decreased by good work ability, good health, mental well-being and physical fitness and increased by constant musculoskeletal symptoms. On the other hand, support from supervisors, job control, work pressure, team climate at work, communication, bullying and discrimination, physical work environment, and sense of coherence appeared to have no association. CONCLUSION: Various psychosocial factors at work and job well-being predict entering rehabilitation. The association between employee health and entering rehabilitation refers to the fact that the selection process for rehabilitation works reasonably well and those in need of rehabilitation are also granted it. In general, these findings coincide well with the Job Well-being Pyramid model. Improving job conditions and well-being at work is likely to decrease the need for rehabilitation.


Assuntos
Emprego , Doenças Profissionais/epidemiologia , Doenças Profissionais/reabilitação , Saúde Ocupacional , Adulto , Idoso , Estudos de Coortes , Feminino , Finlândia , Inquéritos Epidemiológicos , Humanos , Satisfação no Emprego , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Fatores de Risco , Carga de Trabalho , Adulto Jovem
9.
J Occup Environ Med ; 53(6): 633-40, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21654433

RESUMO

OBJECTIVE: To study the association between employee well-being and sick leave, occupational accident, and disability pension. METHODS: A random population of 967 civil servants participated in a survey on psychosocial factors and health at work in 2000 in Finland. The median follow-up time was 7.3 years. RESULTS: The risks of sick leave and disability pension were decreased by job satisfaction (RR = 0.78, 95% CI = 0.58 to 1.05; RR = 0.47, CI = 0.20 to 1.06; respectively), good work ability (RR = 0.35, CI = 0.22 to 0.56; RR = 0.11, CI = 0.04 to 0.33), good health (RR = 0.42, CI = 0.27 to 0.64; RR = 0.32, CI = 0.11 to 0.98), and strong sense of coherence (RR = 0.53, CI = 0.36 to 0.79; RR = 0.17, CI = 0.07 to 0.37). Employee well-being was also associated with occupational accident but somewhat less consistently. CONCLUSIONS: Employee well-being is associated with sick leave, occupational accident, and disability pension. It is important to find means to support employee well-being both in general and at work.


Assuntos
Nível de Saúde , Satisfação no Emprego , Saúde Mental , Licença Médica/estatística & dados numéricos , Acidentes de Trabalho/estatística & dados numéricos , Adulto , Idoso , Estudos de Coortes , Pessoas com Deficiência/estatística & dados numéricos , Feminino , Finlândia , Governo , Humanos , Seguro por Deficiência/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Análise de Regressão , Inquéritos e Questionários , Local de Trabalho/psicologia , Adulto Jovem
10.
Am J Emerg Med ; 27(1): 128.e5-128.e6, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19041554

RESUMO

We report a case of severe ethanol intoxications in a 14-year-old boy whose starting blood alcohol concentration was 490 mg/dL. The intoxication led to coma with hypoventilation, hypoxemia, hypothermia, and a life-threatening situation. Elimination of ethanol followed nonlinear first-order concentration-dependent pharmacokinetics. Fluid balance was disturbed because of marked diuresis, and respirator treatment was needed. The treatment of fluid balance and the risk of hypoxemia in severe alcohol poisoning are emphasized.


Assuntos
Transtornos Induzidos por Álcool/terapia , Intoxicação Alcoólica/terapia , Etanol/farmacocinética , Desequilíbrio Hidroeletrolítico/terapia , Adolescente , Bebidas Alcoólicas/efeitos adversos , Coma/etiologia , Etanol/efeitos adversos , Humanos , Masculino , Desequilíbrio Hidroeletrolítico/etiologia
11.
J Occup Environ Med ; 50(11): 1216-27, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19001948

RESUMO

OBJECTIVE: The aim of this systematic literature analysis was to study the association between work health promotion and job well-being, work ability, absenteeism, and early retirement. This systematic review is a part of a large research project studying multiple workplace factors and interventions that may affect workers' health and well-being. METHODS: Original articles published in 1970 to 2005 were searched in Medline and PsycINFO databases, the main search terms being health promotion, well-being, work ability, sick leave, and disability pension. Out of 1312 references and 35 potentially eligible publications, 10 studies were included in the analysis. Other sources producing 36 eligible studies, 46 studies in total were included in the analysis. RESULTS: There is moderate evidence that work health promotion decreases sickness absences (risk ratio [RR], 0.78; range, 0.10 to 1.57) and work ability (RR, 1.38; range, 1.15 to 1.66). It also seems to increase mental well-being (RR, 1.39; range, 0.98 to 1.91), but not physical well-being. There is no evidence on disability pension. Exercise seems to increase overall well-being (RR, 1.25; range, 1.05 to 1.47) and work ability (RR, 1.38; range, 1.15 to 1.66), but education and psychological methods do not seem to affect well-being or sickness absences. Sickness absences seem to be reduced by activities promoting healthy lifestyle (RR, 0.80; range, 0.74 to 0.93) and ergonomics (RR, 0.72; range, 0.13 to 1.57). CONCLUSIONS: Work health promotion is valuable on employees' well-being and work ability and productive in terms of less sickness absences. Activities involving exercise, lifestyle, and ergonomics are potentially effective. On the other hand, education and psychological means applied alone do not seem effective. Work health promotion should target both physical and psychosocial environments at work.


Assuntos
Absenteísmo , Exercício Físico , Promoção da Saúde , Nível de Saúde , Saúde Mental , Saúde Ocupacional , Licença Médica , Pessoas com Deficiência , Ergonomia , Humanos , Pensões , Aposentadoria
12.
Eur J Cancer ; 44(15): 2122-32, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18707867

RESUMO

BACKGROUND: Systematic reviews on the association between statin therapy and cancer have focused on randomised trials without assessing the quality of evidence. We aimed to review the overall evidence taking study quality into consideration. METHODS: Publications of original studies on the effect of statin treatment on cancer in adult patients were searched on MEDLINE, EMBASE and CENTRAL databases upto October 2007. Our search yielded 37 eligible original studies out of 3607 references. Five studies were additionally found through manual search. Thus, 42 studies were included in the analyses: 17 randomised controlled trials, 10 cohort studies, and 15 case-control studies. FINDINGS: Statins had no effect on the overall incidence of cancer (median risk ratio (RR) 0.96, range 0.72 to 1.2), or on the incidence of lung (median RR 0.92, range 0.83 to 3.0), breast (median RR 1.04, range 0.74 to 19) or prostate cancer (median RR 0.96, range 0.33 to 1.7). They seemed to protect from stomach (median RR 0.59, range 0.40 to 0.88) and liver cancer (median RR 0.62, range 0.33 to 1.2), and from lymphoma (median RR 0.74, range 0.28 to 2.2). They increased the incidence of both melanoma (median RR 1.5, range 1.3 to 1.7) and non-melanoma skin cancer (median RR 1.6, range 1.2 to 2.2). The effect varied, yet inconsistently, by statin type. The median follow-up time was 4 years. The strength of evidence was mostly weak. INTERPRETATION: The evidence suggests that statins do not have short-term effects on cancer risk. The evidence on potentially protective or harmful effects is inconclusive. High quality cohort studies with long follow-up are needed to resolve the issue.


Assuntos
Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Neoplasias/induzido quimicamente , Medicina Baseada em Evidências , Humanos , Projetos de Pesquisa , Medição de Risco/métodos
13.
J Occup Environ Med ; 50(8): 904-15, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18695449

RESUMO

OBJECTIVE: The aim of this systematic literature analysis was to study the association between leadership and well-being at work and work-related health. These intermediate outcomes are supposed to predict work-related loss of productivity and disability at work. METHODS: Original articles published in 1970 to 2005 were searched in MEDLINE and PsycINFO databases in a systematic manner. The main search terms were leadership, job satisfaction, well-being, sick leave, and disability pension. Out of 303 references, 93 publications were retrieved. In addition, other sources produced 69 articles. The strength of evidence was evaluated comprehensively. Altogether, 109 articles were thoroughly analyzed; our conclusions are based on 27 articles providing the best evidence. RESULTS: There was moderate evidence that leadership is associated with job well-being (risk ratio [RR] 1.40, range 1.36 to 1.57), sick leave (RR 0.73, range 0.70 to 0.89), and disability pension (RR 0.46, range 0.42 to 0.59). The evidence was weak on that leadership is associated with job satisfaction (median RR 2.23, range 1.30 to 3.51) but not with job performance (RR 1.13, range 0.55 to 1.20). CONCLUSIONS: There is a relative lack of well-founded prospective studies targeting the association between leadership and employee health, but the few available good studies suggest an important role of leadership on employee job satisfaction, job well-being, sickness absences, and disability pensions. The relationship between leadership and job performance remains unclear.


Assuntos
Satisfação no Emprego , Liderança , Licença Médica , Humanos , Cultura Organizacional , Aposentadoria , Risco
14.
J Rehabil Med ; 40(10): 796-804, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19242615

RESUMO

OBJECTIVE: To evaluate the effects of rehabilitation on sickness absenteeism, return to work and disability pensions among persons of working age. METHOD: Original articles published during 1970-2005 indexed in Medline and PsycINFO databases were studied systematically. The main search terms were rehabilitation, sick leave and disability pension. Out of 576 references, 41 potentially eligible publications were retrieved; other sour-ces producing 21 articles. Forty-five studies were included in the analysis. RESULTS: There is moderate evidence that return-to-work programmes decrease long sick leaves (risk ratio (RR) 0.46, range 0.25-1.10) and multimodal rehabilitation decreases the risk of disability pension (RR 0.64, range 0.52-1.14), counselling, exercise, multimodal medical rehabilitation or return-to-work programmes having no effect on return to work. Based on mainly weak evidence, early rehabilitation seems to reduce both absenteeism and disability pension. CONCLUSION: Any type of rehabilitation may have an effect at an early stage of decreased work ability, being ineffective later on if applied as the only mode of rehabilitation. Where chronic disability is already present, multimodal medical rehabilitation needs to be combined with vocational rehabilitation in order to reduce absenteeism and disability pensions. It is essential that the workplace is integrated into rehabilitation.


Assuntos
Reabilitação Vocacional , Licença Médica , Avaliação da Deficiência , Humanos , Pensões , Fatores de Tempo , Avaliação da Capacidade de Trabalho , Local de Trabalho
16.
Eur J Clin Pharmacol ; 58(2): 137-41, 2002 May.
Artigo em Inglês | MEDLINE | ID: mdl-12012147

RESUMO

OBJECTIVES: The purpose of the study was to find out whether there is an association between use of enzyme-inducing antiepileptic medicines and cancer. METHODS: : A cohort of 14,487 male and 13,932 female patients who received reimbursement for antiepileptic drugs (AEDs) in 1979-1981 in Finland was followed for subsequent cancers up to 1997 through the Finnish Cancer Registry. RESULTS: During the follow-up, 2242 cancer cases were observed, while the expected number based on national incidence rates was 1743. Over 40% of the excess was attributable to cancer of the brain and nervous system [standardised incidence ratio (SIR) 4.30, 95% confidence interval (CI) 3.81, 4.82]. The relative risk of meningiomas was very high (SIR 46.6, 95% CI 22.3, 85.6) only during the first year of reimbursement, while the risk of gliomas remained tenfold or higher for 7 years and was significantly increased for 19 years in patients taking AEDs. Also cancers of the larynx (SIR 1.77), liver (1.71), pancreas (1.35), colon (1.32), stomach (1.30) and lung (1.29) showed statistically increased risks. CONCLUSION: As epilepsy can be a symptom of cancers of the nervous system, the role of AEDs in their occurrence is speculative albeit possible. The excess of some cancers might be attributable to enzyme-inducing antiepileptic drugs, but the excess is not very high compared with the benefits obtained with these drugs.


Assuntos
Anticonvulsivantes/efeitos adversos , Neoplasias/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Anticonvulsivantes/administração & dosagem , Criança , Pré-Escolar , Estudos de Coortes , Intervalos de Confiança , Feminino , Finlândia/epidemiologia , Seguimentos , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Neoplasias/induzido quimicamente , Sistema de Registros
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