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1.
Eur J Trauma Emerg Surg ; 40(1): 37-43, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26815775

RESUMO

INTRODUCTION: Diagnosis of Triplane fractures remains difficult in common practice. Aim of the study was the evaluation of the fracture pattern and the benefit of cross-sectional imaging in classification of Triplane-fractures. MATERIAL AND METHODS: A total of 27 pediatric patients treated for ankle fractures were identified from patient charts. Radiographic images of epiphyseal fractures (X-rays and additional cross-sectional imaging) were blinded evaluated by 13 observers to answer a specific questionnaire regarding type or fracture and treatment suggestion. RESULTS: There were seven Triplane-I and eight Triplane-II fractures. The other physeal ankle fracture group consisted of four patients with a Twoplane-fracture, five Salter-and-Harris (SH) II, one SH-III, and two SH-IV fracture. Accuracy of classification improved considerably depending on the experience of the observer in pediatric trauma care. Surgeons specialized in pediatric trauma care classified correctly with conventional X-rays in 48.1 % of all cases presented versus 31.5 % appropriate diagnosis by younger fellows. Accuracy in exact specification of Triplane-fractures was comparable lesser in younger fellows (31.1 vs. 22 %). Cross-sectional imaging improved classification of all fractures in both groups (75.6 % specialized vs. 47.3 % non specialized). Whereas availability of cross-sectional imaging improved treatment recommendation in specialized surgeons this benefit was not detectable for the doctors without specialization. Evaluation of fracture pattern showed a relatively stereotypical fracture pattern in Triplane-II fractures, whereas Triplane-I fractures were more variable. CONCLUSION: The additional information of cross-sectional imaging seems helpful for any physician in finding the right classification of a pediatric ankle fracture. However, the additive information appears especially viable for experienced surgeons to suggest the appropriate treatment.

2.
Orthopade ; 42(11): 977-85; quiz 986-7, 2013 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-24190243

RESUMO

Fractures of the distal humerus belong to the most common injuries of the upper arm in childhood. Most frequently occurring is the supracondylar fracture of the distal humerus. In these cases and in the second most common epicondylar fractures, the metaphysis is affected and these fractures are therefore extra-articular. They have to be distinguished from articular fractures regarding therapy and prognosis. The growth potential of the distal epiphysis is very limited as is the possibility of spontaneous correction so that major dislocations should not be left uncorrected. Unstable and especially dislocated articular fractures must be anatomically reconstructed employing various osteosynthetic techniques, mostly combined with immobilization. Insufficient reconstruction, growth disturbance and non-union can result in axial deformities, such as cubitus valgus and varus, restriction of motion, pain and nerve palsy.


Assuntos
Fixação Interna de Fraturas/instrumentação , Fixação Interna de Fraturas/métodos , Fraturas do Úmero/cirurgia , Imobilização/instrumentação , Imobilização/métodos , Criança , Pré-Escolar , Feminino , Humanos , Masculino
3.
Z Orthop Unfall ; 151(3): 264-71, 2013 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-23771331

RESUMO

BACKGROUND: There are a variety of surgical strategies for the treatment of traumatic thoracolumbar vertebral fractures. There is still no proof for the superiority of any strategy concerning clinical or radiological outcomes. The aim of this study was the evaluation of residual complaints and correlation with radiological findings. PATIENTS AND METHODS: 87 patients, who underwent different types of surgery for vertebral fractures of the thoracolumbar region were included. Patients were treated by posterior stabilisation with internal fixation alone, by a combined approach using posterior internal fixation and anterior fusion by bone graft from the iliac crest with or without additional anterior plating or with a combined approach using posterior stabilisation and anterior implantation of an expandable titanium cage. Data were collected using results of physical examination, standardised testing of several established quality of life scores (SF-36, VAS, LBOS and Oswestry score) as well as radiological findings (post-traumatic kyphosis, loss of correction). RESULTS: There was no difference in the overall results of quality of life in the different subgroups. Analysis of the subgroups revealed differences in the complaints according to the surgical strategy used (a high rate of non-fusion where bone grafts, especially without additional anterior plating were used, combined with a high rate of bone graft morbidity, intercostal neuralgia in cage implantation). Loss of correction as documented in the radiological course showed a maximum in patients who underwent posterior stabilisation without an additional anterior approach. There was no correlation of loss of correction and quality of life. CONCLUSION: Overall outcomes of the four surgical strategies were comparable in our study concerning loss of correction and quality of life, respectively. The use of bone grafts, however, results in a high rate of non-fusion with a remarkable number of patients complaining about bone graft morbidity. Therefore we prefer the use of expandable titanium cages for anterior stabilisation if additional anterior stabilisation is necessary due to type of fracture or damage of adjacent discs. In any other cases, a limited approach by posterior instrumentation alone should be considered.


Assuntos
Complicações Pós-Operatórias/epidemiologia , Qualidade de Vida , Fraturas da Coluna Vertebral/diagnóstico , Fraturas da Coluna Vertebral/cirurgia , Fusão Vertebral/estatística & dados numéricos , Vértebras Torácicas/lesões , Tomografia Computadorizada por Raios X/estatística & dados numéricos , Adolescente , Adulto , Idoso , Comorbidade , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Recuperação de Função Fisiológica , Fatores de Risco , Vértebras Torácicas/cirurgia , Resultado do Tratamento , Adulto Jovem
4.
Eur J Trauma Emerg Surg ; 39(5): 443-4, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26815438
5.
Eur J Trauma Emerg Surg ; 39(5): 455-60, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26815440

RESUMO

BACKGROUND: Therapy of vertebral fractures in the elderly is a growing challenge for surgeons. Within the last two decades, the use of polymethylmethacrylate (PMMA) in the treatment of osteoporotic vertebral fractures has been widely established. Besides vertebroplasty and kyphoplasty, the augmentation of pedicle screws with PMMA found widespread use to strengthen the implant-bone interface. Several studies showed an enhanced pullout strength of augmented screws compared to standard pedicle screws in osteoporotic bone models. To validate the clinical relevance, we analyzed postoperative radiologic follow-up data in regard to secondary loss of correction and loosening of pedicle screws in elderly patients. MATERIALS AND METHODS: In this retrospective comparative study, 24 patients admitted to our level I trauma center were analyzed concerning screw loosening and secondary loss of correction following vertebral fracture and posterior instrumentation. Loss of correction was determined by the bisegmental Cobb angle and kyphosis angle of the fractured vertebra. Follow-up computed tomography (CT) scans were used to analyze the prevalence of clear zones around the pedicle screws as a sign of loosening. RESULTS: In 15 patients (mean age 76 ± 9.3 years) with 117 PMMA-augmented pedicle screws, 4.3 % of screws showed signs of loosening, whereas in nine patients (mean age 75 ± 8.2 years) with 86 uncemented screws, the loosening rate was 62.8 %. Thus, PMMA-augmented pedicle screws showed a significantly lower loosening rate compared to regular pedicle screws. Loss of correction was minimal, despite poor bone quality. There was significantly less loss of correction in patients with augmented pedicle screws (1.1° ± 0.8°) as compared to patients without augmentation (5° ± 3.8°). CONCLUSION: The reinforcement of pedicle screws using PMMA augmentation may be a viable option in the surgical treatment of spinal fractures in the elderly.

6.
Eur J Trauma Emerg Surg ; 39(5): 461-8, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26815441

RESUMO

BACKGROUND: Within the last two decades the use of polymethylmethacrylate (PMMA) in the treatment of osteoporotic vertebral fractures has been established widely. Several techniques of cement application in spinal surgery have been described. Besides classical vertebroplasty, kyphoplasty and related techniques that reinforce stability of the fractured vertebral body itself, augmentation of pedicle screws became an issue in the past 10 years. Aim of this technique is strengthening of the implant-bone-interface and the prevention of loosening and failure of posterior instrumentation in limited bone quality due to osteoporosis. PMMA use in spinal surgery always bears the risk of cement leakage and cement embolism. There are only few publications dealing with cement leakage in pedicle screw augmentation. We examined our cohort concerning incidence and type of leakage in comparison to the literature. In particular, we evaluated a possible role of intrathoracic pressure during cementation procedure. PATIENTS AND METHODS: In this retrospective study 42 patients were included. Mean age was 74 (57-89) years. 311 fenestrated, augmented screws were analyzed postoperatively concerning leakage and subsequent pulmonary embolism of cement particles. Overall, there was a leakage rate of 38.3 %, and 28.6 % of patients showed pulmonary embolism of PMMA. During surgery, patients were in part ventilated with a positive end-expiratory pressure (PEEP) of 15 cmH2O during cement injection. These individuals showed significantly less leakage locally as well as less PMMA-emboli in the pulmonary circulation in contrast to patients ventilated without increased PEEP. CONCLUSION: PEEP elevation during administration of PMMA via fenestrated pedicle screws is reducing the leakage rate in spinal surgery. These beneficial effects warrant further evaluation in prospective studies.

7.
Eur J Trauma Emerg Surg ; 39(5): 469-76, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26815442

RESUMO

PURPOSE: Although there are currently many different strategies and recommendations in the therapy of cervical spine fractures in elderly patients, there are still no generally accepted treatment algorithms. The aim of the present study was to analyze the morbidity, mortality, and outcome of operated cervical spine injuries in the elderly. METHODS: This study presents a retrospective review of 69 patients aged 65 years or older admitted to our level I trauma center with cervical spine injury, who had undergone surgical treatment. The data were acquired by analysis of the hospital inpatient enquiry system and radiological review. RESULTS: The ratio between male and female patients was 37:32. The average age of the patients was 76 years (ranging from 65 to 96 years) for males and 80 years (ranging from 66 to 93 years) for females. Injury to the cervical spine was caused by low-energy trauma in 71 % and high-energy trauma in 29 %, respectively. 55.1 % sustained isolated cervical spine injuries, 39.1 % injuries to two adjacent vertebrae, 2.9 % injuries to three adjacent vertebrae, and 2.9 % an odontoid fracture combined with associated fracture(s) in non-contiguous vertebra(e). Isolated spine injury level was dominated by C2 (47.8 %). The most common site for injuries to two adjacent vertebrae was observed at C6/C7 (14.5 %). The morbidity included cerebral complications, respiratory complications, Clostridium difficile-associated disease, heart failure, and acute renal failure. Operative complications included dislocation/malposition, neurovascular lesions, wound infection, and transient swallowing difficulty. The mortality rate at 3 months was 26.1 %, with an in-hospital mortality of 21.7 %. Age was associated with mortality at 3 months. A cervical fracture-induced neurological deficit was documented in 26.1 %, resulting in a mortality of 44.4 % (8/18). Twenty-seven of 33 patients living at home/nursing home at the time of injury returned to their home/nursing home after their hospitalization. The overall outcome was predominantly related to age and the severity of neurological deficit. CONCLUSIONS: In elderly patients with cervical spine fractures, the hospital course is complicated by medical issues and early mortality rates are significant. Therefore, treatment strategies should be carefully individualized to the patients and their comorbidities.

8.
Unfallchirurg ; 116(6): 517-23, 2013 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-22101778

RESUMO

BACKGROUND: Complex procedures in knee surgery, such as anterior cruciate ligament (ACL) reconstruction with the double bundle technique are not specially recognized within the German diagnosis-related groups (G-DRG) system. Hence, the goal of the present study was to perform a cost unit calculation and evaluate how ACL reconstruction in single versus double bundle techniques is remunerated. PATIENTS AND METHODS: In 30 patients ACL reconstruction was performed with the single bundle technique (group A) and in 21 an anatomic double bundle reconstruction (group B) was performed. All costs including those for human resources, implants and materials, as well as general costs for administration and facilities were calculated. RESULTS: All cases entered one DRG category, the I30Z "complex procedures at the knee joint". Thus, the revenue in 2008 was 2,996.65 euro per case and in 2009 3,120.35 euro per case. Calculating all costs, the profit contributions in 2008 and 2009 were 592,42 euro and 716,12 euro, respectively for group A. However, in group B the profit contributions were 314,68 euro and 438,38 euro, respectively. CONCLUSION: Performing the double bundle technique for ACL reconstruction in a university hospital setting, significant cost reductions are needed to achieve the revenue generated by the single bundle technique. Additional changes of the relative weighting in the DRG are also necessary.


Assuntos
Reconstrução do Ligamento Cruzado Anterior/economia , Ligamento Cruzado Anterior/cirurgia , Custos de Cuidados de Saúde/estatística & dados numéricos , Hospitalização/economia , Hospitais Universitários/economia , Traumatismos do Joelho/economia , Traumatismos do Joelho/cirurgia , Adolescente , Adulto , Reconstrução do Ligamento Cruzado Anterior/estatística & dados numéricos , Criança , Feminino , Alemanha/epidemiologia , Hospitalização/estatística & dados numéricos , Hospitais Universitários/estatística & dados numéricos , Humanos , Traumatismos do Joelho/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Resultado do Tratamento , Adulto Jovem
9.
Unfallchirurg ; 115(2): 169-72, 2012 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-21503801

RESUMO

We present a case of a pregnant woman (32nd gestational week) that suffered from a chronic non-healing wound at the distal radius. Skeletal tuberculosis was finally diagnosed and treated successfully with staged surgical therapy combined with appropriate medication. One year after surgical treatment, the outcome of the mother was excellent and the baby did not suffer from any disease related to operative procedures or pharmacotherapy. Operative treatment of skeletal tuberculosis (especially osteoarticular and vertebral tuberculosis) in combination with tuberculostatic therapy during pregnancy and lactation seem to be the appropriate treatment with minimal risk for the child and excellent outcome for the mother.


Assuntos
Complicações Infecciosas na Gravidez/cirurgia , Rádio (Anatomia)/cirurgia , Tuberculose Osteoarticular/cirurgia , Articulação do Punho/cirurgia , Adulto , Antituberculosos/uso terapêutico , Terapia Combinada , Comportamento Cooperativo , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Comunicação Interdisciplinar , Imageamento por Ressonância Magnética , Gravidez , Complicações Infecciosas na Gravidez/diagnóstico por imagem , Terceiro Trimestre da Gravidez , Radiografia , Rádio (Anatomia)/patologia , Tuberculose Osteoarticular/diagnóstico , Articulação do Punho/patologia
10.
Orthopade ; 39(7): 704-10, 2010 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-20535446

RESUMO

Traumatic vertebral body fractures are different from the osteoporotic vertebral sintering fractures with regard to accruement, classification and surgical treatment. The standard therapeutic regimen for traumatic vertebral fracture implies sufficient analgetic as well as antiosteoporotic medication and physiotherapy. In cases of A1 fractures and A2.1/A2.2 fractures, minimally invasive treatment strategies have proven to be appropriate treatment options when conservative treatment fails. Unstable fractures, the presence of neurological deficits or stenosis of the canal require conventional operative treatment. Due to reduced bone quality and age-dependent biomechanical changes, distinct operative procedures and strategies - cement augmentation of pedicle screws, additional cement augmentation of the fractured vertebra - for complex traumatic vertebral fractures have been established.


Assuntos
Cimentos Ósseos/uso terapêutico , Parafusos Ósseos , Osteoporose/complicações , Osteoporose/terapia , Fraturas da Coluna Vertebral/etiologia , Fraturas da Coluna Vertebral/terapia , Vertebroplastia/instrumentação , Desenho de Equipamento , Humanos , Efeito Placebo , Resultado do Tratamento , Vertebroplastia/métodos
11.
Orthopade ; 39(3): 237-46, 2010 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-20177879

RESUMO

Due to the high incidence of concomitant neurological lesions, standardized clinical and radiologic diagnostic procedures in cervical spine injuries are mandatory. Magnetic resonance imaging or a stress X-ray should be performed when discoligamentous injuries are suspected. The three most important pillars in the treatment of cervical spine injuries are the surgical indication, the surgical approach and the choice of implant. However, despite prompt and appropriate therapy many of these injuries lead to permanent functional impairment depending on the type of fracture. This article summarizes the most frequent fracture types of the cervical spine, as well as the corresponding therapeutic options and outcome.


Assuntos
Vértebras Cervicais/lesões , Vértebras Cervicais/cirurgia , Fixação de Fratura/instrumentação , Fixação de Fratura/métodos , Osteotomia/métodos , Fraturas da Coluna Vertebral/diagnóstico , Fraturas da Coluna Vertebral/cirurgia , Humanos , Osteotomia/instrumentação
12.
Unfallchirurg ; 113(1): 36-43, 2010 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-19997717

RESUMO

BACKGROUND: The prognosis of severely injured patients depends on a rapid diagnosis and early initiation of therapeutic procedures. MATERIAL AND METHODS: To that end a total of 6,927 prospectively documented severely injured patients with an Injury Severity Score (ISS) > or =16 from the Trauma Registry of the German Trauma Society (DGU, 2002-2007) were analyzed with respect to time intervals during emergency trauma treatment. RESULTS: In cases of indicated emergency surgery the average +/-time in the emergency department was 42+/-34 min, in cases of early surgery 75+/-41 min and in cases of transfer to the intensive care unit (ICU) 83+/-43 min, respectively. The time from the last diagnostic procedure until the end of emergency treatment was 12 min (emergency surgery), 26 min (early surgery) and 32 min (ICU), respectively. Level I (78 min) and level II (72 min) trauma centres showed similar mean times in the emergency department while level III trauma centres had a mean time of 86 min. According to this analysis no general correlation between shorter duration of emergency trauma care and reduced mortality could be observed. CONCLUSION: The duration of time intervals depends on injury severity, treatment after completion of emergency trauma care and the level of the trauma centre. Time management in emergency trauma care can potentially be optimized after completion of the last diagnostic procedure in the emergency room.


Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Sistema de Registros , Ressuscitação/estatística & dados numéricos , Estudos de Tempo e Movimento , Centros de Traumatologia/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adulto , Feminino , Alemanha/epidemiologia , Humanos , Incidência , Masculino , Fatores de Tempo , Ferimentos e Lesões/terapia
13.
Unfallchirurg ; 112(9): 771-7, 2009 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-19641893

RESUMO

Conflicting reports exist regarding the quality of prehospital treatment of pediatric trauma patients. The purpose of this investigation was to determine whether prehospital treatment and emergency management in pediatric trauma patients were similar to that in adult patients. All patients who had been prospectively documented in the registry of the German Trauma Society (DGU) between 2002 and 2005 were selected for this study. A total of 312 matched pairs of adult and pediatric patients suffering from identical injuries were defined and compared with respect to cause of trauma, diagnostic and therapeutic interventions, and outcome. Within the study group, 63% were male, and the average age was 10.5+/-2.7 (SD) years in the pediatric group and 33.9+/-9.3 years in the adult group. There was no significant difference regarding prehospital intubation, reanimation, fluid management, chest drainage, ground and air transport to the hospital, time to arrival or interval in the emergency room. In contrast, significant differences (p<0.05) were observed in terms of the cause of trauma and pre-existing diseases. Pediatric trauma patients were not triaged or treated differently from adult trauma patients in respect to key issues of prehospital and early clinical trauma management.


Assuntos
Serviços Médicos de Emergência/estatística & dados numéricos , Garantia da Qualidade dos Cuidados de Saúde , Sistema de Registros , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/terapia , Adulto , Criança , Estudos de Coortes , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Prevalência , Medição de Risco , Fatores de Risco , Estudantes/estatística & dados numéricos , Resultado do Tratamento
14.
Chirurg ; 80(11): 1042-52, 2009 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-19585088

RESUMO

Fractures of the forearm in children represent one of the most frequent injuries. Most are monotraumatic occurring during sport or leisure activities. Diagnosis can be made by conventional X-ray examination in 2 planes. Distal forearm fractures are classified into epiphyseolysis and epiphyseal fractures, metaphyseal greenstick and buckle fractures, complete distal radius and forearm fractures as well as Galeazzi lesions. The vast majority of cases without relevant dislocation can be treated with immobilization employing a cast. The remaining fractures have to be repositioned and restored depending on age and degree of dislocation.The state of the art in surgical therapy is the Kirschner wire osteosynthesis after closed reduction. Especially meta-diaphyseal fractures can alternatively be stabilized with plate osteosynthesis or external fixation. Following these therapeutic principles, prognosis is excellent and most of the injuries heal without any functional impairment.


Assuntos
Epifise Deslocada/cirurgia , Fixação Interna de Fraturas/métodos , Fraturas do Rádio/cirurgia , Fraturas Salter-Harris , Fraturas da Ulna/cirurgia , Traumatismos do Punho/cirurgia , Adolescente , Placas Ósseas , Fios Ortopédicos , Criança , Pré-Escolar , Técnicas de Apoio para a Decisão , Epifise Deslocada/diagnóstico por imagem , Lâmina de Crescimento/diagnóstico por imagem , Lâmina de Crescimento/cirurgia , Humanos , Lactente , Imageamento por Ressonância Magnética , Osteogênese por Distração , Osteotomia , Cuidados Pós-Operatórios , Radiografia , Fraturas do Rádio/classificação , Fraturas do Rádio/diagnóstico por imagem , Sensibilidade e Especificidade , Fraturas da Ulna/classificação , Fraturas da Ulna/diagnóstico por imagem , Traumatismos do Punho/classificação , Traumatismos do Punho/diagnóstico por imagem
15.
Unfallchirurg ; 111(10): 821-8, 2008 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-18622589

RESUMO

OBJECTIVE: Presentation of our own experiences and results of an early clinical algorithm for treatment integrating emergency embolization (TAE) in cases of unstable pelvic ring fractures with arterial bleeding. METHOD: Consecutive patient series from April 2002 to December 2006 at a level 1 trauma center. The data of the online shock room documentation (Traumawatch) of patients with a pelvic fracture and arterial bleeding detected on multislice computed tomography (MSCT) were examined for the following parameters: demographic data, injury mechanism, fracture classification according to Tile/AO and severity of the pelvic injury assessed with the Abbreviated Injury Score (AIS), accompanying injuries with elevation of the cumulative injury severity according to the Injury Severity Score (ISS), physiological admission parameters (circulatory parameters and initial Hb value) as well as transfusion requirement during treatment in the shock room, time until embolization, duration of embolization, and source of bleeding. RESULTS: Of a total of 162 patients, arterial bleeding was detected in 21 patients by contrast medium extravasation on MSCT, 12 of whom were men and 9 women with an average age of 45 (14-80) years. The mechanism of injury was high energy trauma in all cases. In 33% it involved type B pelvic fractures and in 67% type C fractures with an average AIS pelvis of 4.4 points (3-5) and a total severity of injury with the ISS of 37 points (21-66). Upon admission 47.6% presented hemodynamic instability with an average Hb value of 7.8 g/dl (3.2-12.4) and an average transfusion requirement of 6 red blood cell units (4-13). The time until the TAE was started was on average 62 min (25-115) with a duration period of the TAE of 25 min (15-67). Branches of the internal iliac artery were identified as the sole source of bleeding. The success rate of TAE amounted to over 90%. CONCLUSION: Interventional TAE represents an effective as well as a fast procedure for hemostasis of arterial bleeding detected on MSCT in patients with pelvic fractures. If an experienced radiologist on 24-h stand-by is assured and the infrastructure is efficient, this can be performed shortly after hospital admission and therefore should be integrated into the early clinical treatment protocol.


Assuntos
Algoritmos , Embolização Terapêutica/métodos , Serviços Médicos de Emergência/métodos , Fraturas Ósseas/complicações , Hemorragia/etiologia , Hemorragia/terapia , Ossos Pélvicos/lesões , Adolescente , Adulto , Sistemas de Apoio a Decisões Clínicas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
16.
Unfallchirurg ; 111(8): 592-8, 2008 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-18443754

RESUMO

The increasing average age in the industrialized nations is leading to an increasing number of elderly traumatized patients. Against this background, an analysis of the age-specific characteristics of geriatric traumatized patients is necessary. In this study, 14,869 patients > or = 18 years were analysed, who were prospectively documented in the registry of the German Trauma Society (DGU) between 1996 and 2005. Patients between 18 and 59 years were defined as the control group; their proportion declined from 81.1% in 1996-2000 to 75.4% in 2001-2005. The average age rose from 41.0 years (1996) to 45.3 years (2005). With increasing age a significant increase in severe head injuries of up to 58.9% (> or = 80 years) could be observed. Older patients stayed for a significantly shorter time in hospital and on the ICU. With a comparable injury severity, the lethality after trauma increased with age (18-59 years 13.8%, 60-69 years 24.1%, 70-79 years 35.5%, > or = 80 years 43.6%). The multiply traumatized geriatric patient is different from the normal group in regard to type of injury, therapy and outcome and should therefore be treated taking this fact into consideration.


Assuntos
Sistema de Registros , Ferimentos e Lesões/mortalidade , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Feminino , Alemanha/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Medição de Risco/métodos , Fatores de Risco
17.
Eur J Histochem ; 51(2): 111-8, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17664161

RESUMO

Age dependent motor unit dedifferentiation is a key component of impaired muscle function in advanced age. Here, we tested the hypothesis that rat muscle histochemical profile during the lifespan of an individual has an age-specific pattern since comprehensive longitudinal studies of muscle differentiation after birth and dedifferentiation in advanced age are scarce. Our results show that extensor digitorum longus muscle (EDL) is comprised only of two fiber types after birth, type slow-oxidative (SO) and type SDH-intermediate (SDH-INT), the latter being indicative for the presence of polyneuronal innervation. In contrast to the constantly growing cross-sectional area of the muscle fibers, a dramatic decrease in SDH-INT proportion occurs between day 14 and 21 after birth resulting in a complete loss of fiber type SDH-INT at the age of 90 days (p<0.05). At the age of 270 days, the fiber type composition of rat EDL dedifferentiates as shown by the reappearance of the SDH-INT type with a further increase at the age of 540 days (p<0.05). These changes in histochemical fiber type spectra are brought about by fiber type conversion within the fast twich fibers. The findings of the present study provide further evidence that fiber type conversion is a basic mechanism leading to motor unit differentiation and dedifferentiation during ontogenesis. Fiber type conversion shows a distinct time specific pattern and is also characteristic for motor unit regeneration after peripheral nerve repair. Factors that influence fiber type conversion and thereby motor unit organization may provide a future therapeutic option to enhance the regenerative capacity of motor units.


Assuntos
Músculo Esquelético/crescimento & desenvolvimento , Músculo Esquelético/metabolismo , Envelhecimento/metabolismo , Envelhecimento/patologia , Animais , Animais Recém-Nascidos , Histocitoquímica , Masculino , Fibras Musculares Esqueléticas/metabolismo , Músculo Esquelético/anatomia & histologia , Ratos , Ratos Sprague-Dawley , Succinato Desidrogenase/metabolismo
18.
Neuroscience ; 136(4): 971-89, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16242846

RESUMO

Approximately 4000 human beings experience a traumatic brain injury each day in the United States ranging in severity from mild to fatal. Improvements in initial management, surgical treatment, and neurointensive care have resulted in a better prognosis for traumatic brain injury patients but, to date, there is no available pharmaceutical treatment with proven efficacy, and prevention is the major protective strategy. Many patients are left with disabling changes in cognition, motor function, and personality. Over the past two decades, a number of experimental laboratories have attempted to develop novel and innovative ways to replicate, in animal models, the different aspects of this heterogenous clinical paradigm to better understand and treat patients after traumatic brain injury. Although several clinically-relevant but different experimental models have been developed to reproduce specific characteristics of human traumatic brain injury, its heterogeneity does not allow one single model to reproduce the entire spectrum of events that may occur. The use of these models has resulted in an increased understanding of the pathophysiology of traumatic brain injury, including changes in molecular and cellular pathways and neurobehavioral outcomes. This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors.


Assuntos
Lesões Encefálicas , Modelos Animais de Doenças , Animais , Comportamento Animal , Lesões Encefálicas/classificação , Lesões Encefálicas/fisiopatologia , Humanos , Camundongos
19.
MAGMA ; 14(3): 233-41, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12098566

RESUMO

In an experimental study MRI was used to compare the pathophysiological changes of brain tissue after lateral fluid percussion injury (FPI) versus cold injury (CI) as models of traumatic brain injury (TBI). Two groups of Sprague-Dawley rats (n=23) were subjected to mild FPI, respectively, CI localized over the right parietal cortex. MRI was performed at different time points including T1w, T2w and T1w-CE (Gd-DTPA 0.2 mmol/kg BW) sequences as well as perfusion-weighted imaging with calculation of regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF). T2w and T1w-CE images showed hyperintense areas in the traumatised cortex demonstrating brain edema and blood-brain barrier (BBB)-breakdown increasing up to 12 h. Perfusion-weighted imaging demonstrated a significant decrease of rCBV and rCBF in the ipsilateral cortex of CI animals compared with the contralateral hemisphere. In contrast, rats of the FPI group showed only slight differences in rCBF and rCBV comparing the left and right cortex. The results of our study confirm that both mild FPI and CI produced focal brain edema with concomitant breakdown of the BBB as a model of TBI. Since differences regarding perfusion are much more pronounced in CI our results suggest that, this model more likely seems to reflect pathophysiological changes of brain ischemia, whereas FPI seems to be better suited to model the pathophysiological characteristics of TBI.


Assuntos
Barreira Hematoencefálica , Edema Encefálico/diagnóstico , Isquemia Encefálica/diagnóstico , Traumatismos Cranianos Fechados/diagnóstico , Imageamento por Ressonância Magnética , Ratos , Animais , Edema Encefálico/etiologia , Isquemia Encefálica/etiologia , Córtex Cerebral/anatomia & histologia , Córtex Cerebral/irrigação sanguínea , Circulação Cerebrovascular , Temperatura Baixa/efeitos adversos , Modelos Animais de Doenças , Traumatismos Cranianos Fechados/etiologia , Pressão/efeitos adversos , Ratos Sprague-Dawley
20.
Kongressbd Dtsch Ges Chir Kongr ; 119: 699-702, 2002.
Artigo em Alemão | MEDLINE | ID: mdl-12704919

RESUMO

Surgical treatment of fractures of adolescents is often difficult as the epiphyses are still open or not yet completely closed. The osteosynthesis chosen has to consider the remaining prospective growth of the affected bone and biomechanical needs. Due to high physical maturity with small remaining growth capacity in adolescents, a number of different techniques known from osteosynthesis in adults with minor modifications can be used to treat these fractures.


Assuntos
Desenvolvimento Ósseo/fisiologia , Fixação Interna de Fraturas/métodos , Fraturas Ósseas/cirurgia , Fraturas Salter-Harris , Adolescente , Adulto , Criança , Feminino , Fraturas Ósseas/diagnóstico por imagem , Lâmina de Crescimento/diagnóstico por imagem , Lâmina de Crescimento/cirurgia , Humanos , Processamento de Imagem Assistida por Computador , Imageamento Tridimensional , Masculino , Puberdade/fisiologia , Fatores Sexuais , Tomografia Computadorizada por Raios X
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