Post-traumatic growth correlates among parents of children with chronic illnesses: A systematic review and meta-analysis.

Parenting a child with a chronic illness presents a complex journey marked by various challenges, along with possible personal growth following these challenges. In this systematic review we present three meta-analyses, in order to examine the associations of post-traumatic growth (PTG) among parents of children with diverse chronic illnesses, and psychological distress, social support, and resilience. Analyzing 34 studies encompassing a total of 5328 parents, the results reveal several key findings. First, PTG was found to be prevalent among the parents. Second, there was no significant correlation between PTG and psychological distress, suggesting that these two processes may exist independently. Third, a positive correlation was observed between PTG and both social support and resilience-related factors, underscoring the role of these factors in fostering growth among parents of children with chronic illnesses. Additionally, illness type emerged as a moderator, affecting the strength of the above-mentioned correlations with PTG. Specifically, in the case of psychiatric illnesses, correlations of PTG with social support and resilience were stronger than in the context of other illnesses. Overall, this review emphasizes the significance of recognizing and addressing PTG correlates among parents of children with chronic illnesses, offering insights for clinical practice.

Beyond social engagement: cognitive training leads to greater cognitive improvement in older adults.

Aging is often accompanied by a decline in cognitive functions, with memory being particularly affected. Recent studies suggest that cognitive training sessions that teach memory strategies relevant to daily life may benefit seniors who live in the community. However, it is possible that the cognitive improvement observed in these programs results from the social encounters embedded in them. In this study, we aimed to investigate the effect of a social cognitive training group, which met regularly for an extended period, on enhancing cognitive indices compared to a control group that only received social engagement meetings without training. Sixty-six participants with a mean age of 78 took part in 12 sessions of a social engagement group, with or without strategy training. Cognitive performance was assessed before and after training using four memory tasks, two similar to the trained tasks (near-transfer tasks) and two novel (far-transfer tasks). Both groups showed a slight improvement in most of the evaluation tasks, but the cognitive training combined with social engagement group showed a significant improvement in the Word Recall and Verbal Fluency tests compared to the social engagement group without training. Our findings suggest that cognitive training sessions may be a useful tool in promoting cognitive improvement among older adults living in the community, even beyond the improvement obtained from the social engagement that occurs during the training sessions.Trial registration number:NCT05016336. Date of registration: 20 August 2021. Retrospectively registered.

Autonomic nervous system responses to social stimuli among autistic individuals: A systematic review and meta-analysis.

Physiological responses to environmental and social stimuli have been studied broadly in relation to psychological states and processes. This may be especially important regarding autistic individuals, who show disparities in social interactions. However, findings from studies assessing autonomic nervous system (ANS) responses of autistic individuals present contradictions, with reports showing both autonomic disparities and intact autonomic functioning. The current study aimed to review the existing literature and to estimate if there is a difference between autistic individuals and neurotypical (NT) individuals in their autonomic responses to social stimuli. Furthermore, the study examined factors that may moderate this difference, including the type of physiological function measured, the level of participation required, as well as the age and intellectual functioning of the participants. The meta-analysis revealed a small and statistically insignificant overall difference between autistic and NT individuals, albeit with high heterogeneity. A further nested moderator analysis revealed a significant difference between autistic and NT individuals in physiological response that reflects mainly a parasympathetic nervous system (PNS) activity. Another difference was found in physiological response that reflects a combined activity of the sympathetic and parasympathetic systems, but only for experimental tasks that demanded active participation in social interactions. These results suggest a distinctiveness in autonomic regulation of autistic individuals in social situations, and point to the PNS as an important study objective for future investigation.

When a Patient Dies From Suicide: A Survey Among Mental Health Professionals in Israel.

Death of patients by suicide can have powerful impacts on mental health professionals (MHPs). The National Program for the Prevention of Suicidality and Suicide at Israel's Ministry of Health decided to invest in MHPs who have lost patients by suicide. Two hundred and two MHPs completed an online self-report survey regarding their emotional response, professional identity, and clinical practice, and the aid they felt would be supportive following a patient's suicide. Results indicated that 35% of MHP experienced at least one death of a patient by suicide. Respondents experienced difficult emotional reactions, and many felt responsible for the suicide. Nearly 50% reported that the patient's suicide affected their clinical practice. Most respondents reported the need for a support framework and information about the processes following a patient's suicide. It is important to increase awareness of the possibility of losing a patient by suicide and offer an appropriate supportive framework.

Cognitive control enhancement in attention deficit hyperactivity disorder (ADHD) and neurotypical individuals.

Cognitive control, which has been localized to the right inferior frontal gyrus (rIFG) based on functional imaging and brain lesion studies, is impaired in patients with ADHD. The present study aims to investigate whether transcranial direct current stimulation (tDCS) over the rIFG might improve cognitive control in ADHD subjects. We hypothesized poorer performance in a cognitive control task, but not in a control language task, in the ADHD subjects. Crucially, following tDCS, we expected the ADHD group to improve their cognitive control. In a double-blind randomized control trial, 42 participants performed the stop signal task (SST) to index their cognitive control level and the language task. Half of them were randomly assigned to the anodal stimulation condition and half to the sham stimulation. The anodal or sham stimulation was applied over the right IFG. Following the stimulation, the participants reset the two tasks to see whether stimulation improved the (predicted) weaker performance in the ADHD group. Stimulation significantly enhanced cognitive control for both groups, with or without ADHD, in the SST task, but no significant stimulation effects were found for the control task. tDCS seems as a promising tool to improve cognitive control in the general population.

Cognitive control in processing ambiguous idioms: evidence from a self-paced reading study.

Idioms entail a competition between bottom-up and top-down activations of literal and figurative meanings. The present study explored the involvement of cognitive control in processing Hebrew ambiguous idioms. Fifty subjects have completed a self-paced reading task and a response inhibition, stop-signal task (SST). Subjects read 26 matched pairs of almost-identical sentences, which included ambiguous idioms (e.g., "break the ice"). The ambiguity was resolved only in the third part of the sentence, which was either literal ("on the parking lot") or figurative ("with funny stories"). Figurative disambiguation parts were read significantly faster than literal ones. The means of the absolute RT difference between the literal and figurative sentences significantly correlated with the SST cognitive control measure. A comparison between three groups of cognitive control levels validated that "Good inhibitors" in the SST were also faster in processing ambiguities. The paper discusses the generality of cognitive control in linguistic processing.

Digitalized transcranial electrical stimulation: A consensus statement.

OBJECTIVE: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aims are to discuss the implementation of tES digital trials by performing a systematic scoping review and strategic process mapping, evaluate methodological aspects of tES digital trial designs, and provide Delphi-based recommendations for implementing digital trials using tES. METHODS: We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for implementing tES digital trials. Delphi-based recommendations (>60% agreement) were provided. RESULTS: The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weaknesses/threats, we listed insufficient supervision (76%) and unclear regulatory status (69%). Many issues related to methodological biases did not reach consensus. Device appraisal showed moderate digitalization readiness, with high safety and potential for trial implementation, but low connectivity. CONCLUSIONS: Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases. SIGNIFICANCE: We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES trials.

Treatments for Social Interaction Impairment in Animal Models of Schizophrenia: A Critical Review and Meta-analysis.

BACKGROUND: While pharmacological treatments for positive symptoms of schizophrenia are widely used, their beneficial effect on negative symptoms, particularly social impairment, is insufficiently studied. Therefore, there is an increasing interest in preclinical research of potentially beneficial treatments, with mixed results. The current review aims to evaluate the efficacy of available treatments for social deficits in different animal models of schizophrenia. STUDY DESIGN: A systematic literature search generated 145 outcomes for the measures "total time" and "number" of social interactions. Standardized mean differences (SMD) and 95% confidence interval (CI) were calculated, and heterogeneity was tested using Q statistics in a random-effect meta-analytic model. Given the vast heterogeneity in effect sizes, the animal model, treatment group, and sample size were all examined as potential moderators. STUDY RESULTS: The results showed that in almost all models, treatment significantly improved social deficit (total time: SMD = 1.24; number: SMD = 1.1). The moderator analyses discovered significant subgroup differences across models and treatment subgroups. Perinatal and adult pharmacological models showed the most substantial influence of treatments on social deficits, reflecting relative pharmacological validity. Furthermore, atypical antipsychotic drugs had the highest SMD within each model subgroup. CONCLUSIONS: Our findings indicate that the improvement in social interaction behaviors is dependent on the animal model and treatment family used. Implications for the preclinical and clinical fields are discussed.

Non-invasive brain stimulation and neuroenhancement.

Attempts to enhance human memory and learning ability have a long tradition in science. This topic has recently gained substantial attention because of the increasing percentage of older individuals worldwide and the predicted rise of age-associated cognitive decline in brain functions. Transcranial brain stimulation methods, such as transcranial magnetic (TMS) and transcranial electric (tES) stimulation, have been extensively used in an effort to improve cognitive functions in humans. Here we summarize the available data on low-intensity tES for this purpose, in comparison to repetitive TMS and some pharmacological agents, such as caffeine and nicotine. There is no single area in the brain stimulation field in which only positive outcomes have been reported. For self-directed tES devices, how to restrict variability with regard to efficacy is an essential aspect of device design and function. As with any technique, reproducible outcomes depend on the equipment and how well this is matched to the experience and skill of the operator. For self-administered non-invasive brain stimulation, this requires device designs that rigorously incorporate human operator factors. The wide parameter space of non-invasive brain stimulation, including dose (e.g., duration, intensity (current density), number of repetitions), inclusion/exclusion (e.g., subject's age), and homeostatic effects, administration of tasks before and during stimulation, and, most importantly, placebo or nocebo effects, have to be taken into account. The outcomes of stimulation are expected to depend on these parameters and should be strictly controlled. The consensus among experts is that low-intensity tES is safe as long as tested and accepted protocols (including, for example, dose, inclusion/exclusion) are followed and devices are used which follow established engineering risk-management procedures. Devices and protocols that allow stimulation outside these parameters cannot claim to be "safe" where they are applying stimulation beyond that examined in published studies that also investigated potential side effects. Brain stimulation devices marketed for consumer use are distinct from medical devices because they do not make medical claims and are therefore not necessarily subject to the same level of regulation as medical devices (i.e., by government agencies tasked with regulating medical devices). Manufacturers must follow ethical and best practices in marketing tES stimulators, including not misleading users by referencing effects from human trials using devices and protocols not similar to theirs.

Meta-Analysis of the Effect of Psychotherapy in an Inpatient Setting: Examining the Moderating Role of Diagnosis and Therapeutic Approach.

OBJECTIVE: The current meta-analysis investigates the efficacy of psychotherapy during psychiatric hospitalization and examines the moderating role of diagnosis and therapeutic approach. METHODS: We conducted systematic searches in literature databases, including PubMed, PsycInfo, and Google Scholar. In total, 37 samples were included for the meta-analysis with a total of 4,443 patients. The primary outcome was the standardized mean differences in clinical status measured by symptomatic and functional measures. RESULTS: The meta-analysis of 22 samples without a control group resulted in the upper end of the medium effect size for the overall effect of treatment during psychiatric hospitalization that included psychotherapy (k = 22, Cohen's d = 0.70, and 95% Cl 0.36 to 1.04). The meta-analysis of 15 samples with a control group resulted in the upper end of the low effect size for the contribution of psychotherapy to the improvement of patients' clinical status measured by symptomatic and functional measures (k = 15, Cohen's d = 0.43, and 95% CI 0.06 to 0.81). No significant effects were uncovered for psychotherapy orientation. Diagnosis was found to moderate the contribution of psychotherapy in an inpatient setting to the improvement of patients' clinical condition. CONCLUSION: Psychotherapy during psychiatric hospitalization may be an effective treatment. Across the various samples, psychotherapy has a moderate effect on the reduction of psychiatric symptoms beyond the overall effect of ward treatment.

The impact of transparency on hemispheric lateralization of idiom comprehension: An rTMS study.

Previous neuropsychological data have equivocal suggestions concerning hemispheric involvement during idiom comprehension. The possible contribution of idioms transparency to the lateralization of figurative language comprehension has not been investigated using an interference technique. To analyse the cortical lateralization of idiom transparency processing, we employed inhibitory repetitive transcranial magnetic stimulation (rTMS) to the left and right dorsolateral prefrontal cortex (DLPFC) during the processing of opaque idioms, transparent idioms, and non-idiomatic literal phrases. Based on the Coarse Semantic Coding theory, we predicted a greater right hemisphere involvement when processing opaque than transparent idioms. Eighteen young healthy participants underwent rTMS pulses at 1 Hz frequency, 110% of motor threshold intensity for 15 min (900 pulses) in two sessions at one-week intervals. In a semantic decision task, participants judged the relatedness of an idiom and a target word. The target word was figuratively or literally related to the idiom, or unrelated. The study also included non-idiomatic sentences. We found that left DLPFC functions are more critical for comprehension of opaque rather than transparent idioms when referring to the figurative associations of the idioms. Opaque idioms, in the context of their figurative meaning, rely more heavily on left hemisphere resources. This finding suggests that opaque idioms are seemingly processed as one unit. Taken together, we believe that the transparency of idiomatic expressions may play an important role in modulating hemispheric functions involved in figurative language processing.

Interpersonal autonomic nervous system synchrony and its association to relationship and performance - a systematic review and meta-analysis.

Interpersonal physiological synchrony is the spontaneous temporal coordination of physiological processes between several individuals. This type of synchrony is critical for human relationships, as it promotes two important outcomes: the quality of the relationships between synchronized individuals, and how well synchronized individuals perform together. Nonetheless a clear estimation of the size of the correlations between interpersonal physiological synchrony and relationship or performance outcomes is missing. To address this gap in knowledge was the main goal of the current meta-analysis. We focused on interpersonal physiological synchrony in measures of autonomic nervous system activity, and specifically we examined the distinct branches of the autonomic nervous system. We conducted two meta-analyses: (1) Estimating the association between interpersonal physiological synchrony and relationship outcomes (2) Estimating the association between interpersonal physiological synchrony and performance outcomes. In the first meta-analysis (i.e., relationships), the overall estimated correlation was small with a marginal significance (ES=0.09, p>.10) and high heterogeneity (I2=76.0%). In further sub-group analysis, we discovered a positive relationship for measures of sympathetic synchrony (ES=0.19, p=.02), a negative relationship for measures of parasympathetic synchrony(ES=-0.21, p=.03), and a positive relationship for measures of combined sympathetic and parasympathetic synchrony (ES =0.16, p=.02). As for the second meta-analysis (i.e., performance), the overall effect size of correlation was small (ES=0.26, p<.01) and heterogeneous (I2=52.7%). Our results emphasize the small effect sizes of the correlations between physiological synchrony and performance or relational outcomes, as well as the differential effects for synchrony in sympathetic versus parasympathetic activity. Combined with the high heterogeneity, our results point to the need for a rigorous a-priori scientific approach which distinguishes between different types of physiological synchrony.

A meta-analysis of client-therapist perspectives on the therapeutic alliance: Examining the moderating role of type of measurement and diagnosis.

BACKGROUND: Clients and therapists often have different perspectives on their therapeutic alliance (TA), affecting the process and outcome of therapy. The aim of the present meta-analysis was to assess the mean differences between clients' and therapists' estimations of TA among clients with severe disturbances, while focusing on two potential moderators: client diagnosis and alliance instrument. METHOD: We conducted a systematic literature search of studies examining both client perspective and therapist perspective on TA in psychotherapy among people with schizophrenia spectrum disorders, personality disorders, and substance misuse disorders. We then analyzed the data using a random-effects meta-analytic model with Cohen's d standardized mean effect size. RESULTS: Heterogeneity analyses (k = 22, Cohen's d = -.46, 95% confidence interval = .31-1.1) produced a significant Q-statistic (Q = 94.96) and indicated high heterogeneity, suggesting that moderator analyses were appropriate. CONCLUSIONS: Our findings show that the type of TA instrument moderates the agreement on TA between client and therapist, but there was no indication of the client's diagnosis moderating the effect. The agreement between client and therapist estimations seems to be dependent on the instrument that is used to assess TA. Specific setting-related instruments seem to result in higher agreement between clients' and therapists' estimations than do more general instruments that are applied to assess TA.

The interactive effect of empathy and motor cortex stimulation on hand gesture comprehension.

Previous research has demonstrated that the Action-Observation Network (AON) is involved in both emotional-embodiment (empathy) and action-embodiment mechanisms. In the current study, we hypothesized that interfering with the AON will impair action recognition and that this impairment will be modulated by empathy levels. Fifty-two participants conducted a semantic decision task of hand gesture recognition, while we interfered with the AON by applying active (n = 26) or sham (n = 26) transcranial Direct Current Stimulation (tDCS) to the hand area of the primary motor cortex. We found that interfering with the AON impaired the performance of participants with high empathy levels and enhanced the performance of participants with low empathy. This finding suggests that the embodiment module may be flexible, and that it can be enhanced in individuals with low empathy by simple manipulation of motor activation.

Modulation of automatic and creative features of the Remote Associates Test by angular gyrus stimulation.

Creative thinking comprises two main components: divergent and convergent thinking. The Remote Associates Test (RAT) was designed to examine the ability to form associative elements into new combinations, however it is widely used as a general creativity measure, without sub-dividing it to its components. Our goal here was to explore the sub-components of the RAT, aiming to link them to the angular gyrus (AG) activation. The AG seems as a good candidate to host both aspects of the RAT, as neuroimaging studies observed deactivation in the AG while participants were engaged in creative tasks, however it also seems to play a role in arithmetic solution retrieval and automatic knowledge retrieval. Our objective was therefore to test whether transcranial direct current stimulation (tDCS) of the AG will influence creative and automatic performance in the RAT. In Experiment 1, in the creative group we administrated cathodal right AG stimulation in order to deactivate the AG aiming to improve divergent features of the RAT. In the automatic group, we administrated double anodal AG stimulation in order to improve convergent features of the RAT and included a control SHAM condition in each group. Experiment 2 activated the AG by stimulation and arithmetic training. We hypothesized that anodal stimulation of the AG will improve automatic convergent features as in Experiment 1. In addition, we expected the arithmetic training to improve the automatic score in the RAT. In Experiment 1, activation of the AG interrupted creative abilities and enhanced automatic abilities. Additionally, deactivation of the AG enhanced creative abilities reflecting divergent thinking. While in Experiment 2 both stimulation and arithmetic training resulted in higher automatic performance. We argue that the RAT measures automatic rather than creative abilities.

Qualitative review and quantitative effect size meta-analyses in brain regions identified by cue-reactivity addiction studies.

OBJECTIVE: Various brain regions have been identified as involved in addictions, yet inconsistencies remain regarding the primary regions that may underlie addictive behaviors. To address this, we conducted a meta-analysis investigating cue-reactivity functional MRI studies for different addictions. METHOD: We explored 8 different addiction-related brain regions in 27 studies (29 samples) using homogeneity tests of effect sizes. RESULTS: An initial qualitative review failed to identify consistent activations in any brain region. We subsequently explored possible moderators related to either the addiction, participants, or study design, and found addiction type to be a relevant moderator, suggesting that different addictions may not necessarily involve the same brain regions. Successive quantitative analyses found that internet gaming addiction and heroin dependence modulated neural activation in the right dorsolateral prefrontal cortex and heroin dependence further in the right orbitofrontal cortex. Our analyses also demonstrated the expected mean effect sizes in each region when conducting cue-reactivity experiments on addictions. CONCLUSIONS: It appears that distinct addiction types may manifest differently in the brain and may moderate cue reactivity to a greater extent than previously suggested factors. This study underscores the need for additional research comparing the neural mechanisms underlying different addiction types. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Non-linear effects of cathodal transcranial direct current stimulation (tDCS) of the primary motor cortex on implicit motor learning.

Transcranial direct current stimulation (tDCS) of 1 mA for 13 min was reported to create a linear inter-dependency between the intensity and duration of the current and the effects of the stimulation. tDCS on the primary motor cortex (M1) has been shown to have an effect on both motor-evoked potential (MEP) and motor learning. However, recent findings have shown that the known linear effect is invalid in a 2 mA stimulation for 20 min, where cathodal stimulation led to excitability, rather than inhibition, as measured by MEP changes. Here we aim to replicate the non-linear effect of cathodal stimulation over the M1, using a cognitive task. Twenty-two healthy subjects participated in three sessions, where they were administered with a 2 mA anodal and cathodal stimulation for 20 min over the left M1, and a sham stimulation, while performing the serial reaction time task (SRTT). The overall analysis failed to show any effects of either polarity of tDCS on SRTT performance and hence did not replicate previous findings. However, given our goal to replicate the previously reported reversed polarity effects on MEP, we conducted an exploratory analysis to see whether there were any more subtle signs of a change in sign of the cathodal effect compared with anodal. Anodal stimulation led to faster performance than cathodal stimulation before 13 min of stimulation have passed, however, after 13 min, the pattern had switched, and performance under cathodal stimulation was faster. We conclude that cathodal tDCS has a non-linear effect, and the known polarity-dependent effects of tDCS shift after 13 min of stimulation, leading to an increased, rather than decreased, excitability.

Null tDCS Effects in a Sustained Attention Task: The Modulating Role of Learning.

The purpose of this study was to investigate sustained attention through modulation of the fronto-cerebral network with transcranial direct current stimulation (tDCS) in adults with attention-deficit/hyperactivity disorder (ADHD) and control participants. Thirty-seven participants (21 with ADHD) underwent three separate sessions (baseline, active tDCS, and sham) and performed the MOXO Continuous Performance Test (CPT). We applied double anodal stimulation of 1.8 mA tDCS for 20 min over the left and right dorsolateral prefrontal cortex (DLPFC), with the cathode over the cerebellum. Baseline session revealed significant differences between ADHD and control participants in the MOXO-CPT attention and hyperactivity scores, validating the MOXO as a diagnostic tool. However, there were no tDCS effects in most MOXO-CPT measures, except hyperactivity, due to a significant learning effect. We conclude that learning and repetition effects in cognitive tasks need to be considered when designing within-subjects tDCS experiments, as there are natural improvements between sessions that conceal potential stimulation effects.

Seeing the World as it is: Mimicking Veridical Motion Perception in Schizophrenia Using Non-invasive Brain Stimulation in Healthy Participants.

Schizophrenia (Sz) is a mental health disorder characterized by severe cognitive, emotional, social, and perceptual deficits. Visual deficits are found in tasks relying on the magnocellular/dorsal stream. In our first experiment we established deficits in global motion processing in Sz patients compared to healthy controls. We used a novel task in which background optic flow produces a distortion of the apparent trajectory of a moving stimulus, leading control participants to provide biased estimates of the true motion trajectory under conditions of global stimulation. Sz patients were significantly less affected by the global background motion, and reported trajectories that were more veridically accurate than those of controls. In order to study the mechanism of this effect, we performed a second experiment where we applied transcranial electrical stimulation over area MT+ to selectively modify global motion processing of optic flow displays in healthy participants. Cathodal and high frequency random noise stimulation had opposite effects on trajectory perception in optic flow. The brain stimulation over a control site and in a control task revealed that the effect of stimulation was specific for global motion processing in area MT+. These findings both support prior studies of impaired early visual processing in Sz and provide novel approaches for measurement and manipulation of the underlying circuits.

The interaction between embodiment and empathy in facial expression recognition.

Previous research has demonstrated that the Action-Observation Network (AON) is involved in both emotional-embodiment (empathy) and action-embodiment mechanisms. In this study, we hypothesized that interfering with the AON will impair action recognition and that this impairment will be modulated by empathy levels. In Experiment 1 (n = 90), participants were asked to recognize facial expressions while their facial motion was restricted. In Experiment 2 (n = 50), we interfered with the AON by applying transcranial Direct Current Stimulation to the motor cortex. In both experiments, we found that interfering with the AON impaired the performance of participants with high empathy levels; however, for the first time, we demonstrated that the interference enhanced the performance of participants with low empathy. This novel finding suggests that the embodiment module may be flexible, and that it can be enhanced in individuals with low empathy by simple manipulation of motor activation.