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1.
Trends Biotechnol ; 40(2): 141-144, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34024648

RESUMO

Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measurements, exchange data, and make decisions automatically over decentralized networks; these systems could improve healthcare, the quality of goods, and supply chain efficiency.


Assuntos
Blockchain , Internet das Coisas , Tecnologia
2.
Neurocrit Care ; 20(1): 21-31, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24343564

RESUMO

BACKGROUND: Spreading depolarization events following ischemic and traumatic brain injury are associated with poor patient outcome. Currently, monitoring these events is limited to patients in whom subdural electrodes can be placed at open craniotomy. This study examined whether these events can be detected using intra-cortical electrodes, opening the way for electrode insertion via burr hole. METHODS: Animal work was carried out on adult Sprague-Dawley rats in a laboratory setting to investigate the feasibility of recording depolarization events. Subsequently, 8 human patients requiring craniotomy for traumatic brain injury or aneurysmal subarachnoid hemorrhage were monitored for depolarization events in an intensive care setting with concurrent strip (subdural) and depth (intra-parenchymal) electrode recordings. RESULTS: (1) Depolarization events can be reliably detected from intra-cortically placed electrodes. (2) A reproducible slow potential change (SPC) waveform morphology was identified from intra-cortical electrodes on the depth array. (3) The depression of cortical activity known to follow depolarization events was identified consistently from both intra-cortical and sub-cortical electrodes on the depth array. CONCLUSIONS: Intra-parenchymally sited electrodes can be used to consistently identify depolarization events in humans. This technique greatly extends the capability of monitoring for spreading depolarization events in injured patients, as electrodes can be sited without the need for craniotomy. The method provides a new investigative tool for the evaluation of the contribution of these events to secondary brain injury in human patients.


Assuntos
Lesões Encefálicas/fisiopatologia , Córtex Cerebral/fisiopatologia , Eletrodos Implantados , Eletroencefalografia/métodos , Adulto , Idoso , Animais , Lesões Encefálicas/cirurgia , Eletrodos Implantados/normas , Eletroencefalografia/instrumentação , Fenômenos Eletrofisiológicos , Estudos de Viabilidade , Humanos , Masculino , Pessoa de Meia-Idade , Ratos , Ratos Sprague-Dawley , Adulto Jovem
3.
BMC Urol ; 13: 18, 2013 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-23565707

RESUMO

BACKGROUND: Benign Prostatic Hypertrophy (BPH) is said to affect at least a third of men over 60. However, the literature contains fewer than 200 reports of prostates over 200g in mass - Giant Prostatic Hypertrophy (GPH). Nephrogenic adenomas are benign lesions of the urinary tract that are believed to represent the local proliferation of shed renal tubular cells implanting at sites of urothelial injury. CASE PRESENTATION: We present the first case in the literature of these two rare pathologies co-existing in the same patient and the successful management and 36-month follow-up of the patient's symptoms with minimally invasive therapy, including the still-uncommon selective prostatic artery embolisation. We also briefly discuss the role of PAX2 in injured renal tissues and nephrogenic adenomas. CONCLUSIONS: Symptomatic Giant Prostatic Hypertrophy (GPH) can be successfully managed with a combination of serial TURPs, 5 α-reductase inhibition and selective prostatic artery embolisation (SPAE).


Assuntos
Adenoma/complicações , Adenoma/terapia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Hiperplasia Prostática/complicações , Hiperplasia Prostática/terapia , Neoplasias da Bexiga Urinária/complicações , Neoplasias da Bexiga Urinária/terapia , Adenoma/diagnóstico , Terapia Combinada , Embolização Terapêutica/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Hiperplasia Prostática/diagnóstico , Resultado do Tratamento , Neoplasias da Bexiga Urinária/diagnóstico
4.
Case Rep Gastroenterol ; 5(2): 438-44, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21960946

RESUMO

We report the case of a 65-year-old Caucasian woman who experienced two separate episodes of acute renal failure within an 18-month period, both requiring emergency admission and complicated treatment. Each episode was precipitated by hypovolaemia from intestinal fluid losses, but from two rare and independent pathologies. Her first admission was attributed to community-acquired Clostridium difficile-associated diarrhoea (CDAD) and was treated in the intensive therapy unit. She returned 18 months later with volume depletion and electrolyte disturbances, but on this occasion a giant hypersecretory villous adenoma of the rectum (McKittrick-Wheelock syndrome) was diagnosed following initial abnormal findings on digital rectal examination by a junior physician. Unlike hospital-acquired C. difficile, community-acquired infection is not common, although increasing numbers are being reported. Whilst community-acquired CDAD can be severe, it rarely causes acute renal failure. This case report highlights the pathological mechanisms whereby C. difficile toxin and hypersecretory villous adenoma of the rectum can predispose to acute renal failure, as well as the values of thorough clinical examination in the emergency room, and early communication with intensivist colleagues in dire situations.

5.
World J Surg ; 35(1): 217-21, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20556606

RESUMO

The snake has served as a medical emblem for more than 2400 years, since its association with the ancient Greek god of medicine and healing, Asclepius, in the 4th century BC. Its symbolic background can be traced further back to the worship of gods of earth's blossom in ancient Egypt and earth-related deities of the archaic period of Greek antiquity. It is featured entwined around a staff of knowledge and wisdom in most anaglyphs depicting Asclepius. The snake was impressed in the Old and the New Testament as well as in the Christian tradition as a symbol of sin, rejuvenation, death, resurrection, asthenia, and therapy. It is postulated that the double-snake motif was reintroduced by Renaissance philosophers as a medical emblem due to the symbolic connections of Hermes with deliverance and redemption. However, its use during the last two centuries seems to lack substantial historical background. The historical, mythological, and traditional retrospection of the snake's symbolism validates its appropriateness in the health-care field.


Assuntos
Medicina Clínica/história , Emblemas e Insígnias/história , Serpentes , Animais , História Antiga , História Medieval , Simbolismo
6.
Urology ; 76(2): 330-1, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19963240

RESUMO

A 36-year-old Caucasian British woman presented with a classic case of right renal colic. Initial plain abdominal radiography and intravenous urography identified an 8 x 5 mm calculus apparently lying within a right lower pole calyx. Following failed extracorporeal lithotripsy and flexible ureterorenoscopy, cross-sectional imaging revealed a misdiagnosis by superposition of an intrahepatic calculus over the right renal shadow. This case serves to support cross-sectional imaging in the diagnosis of renal calculi.


Assuntos
Cálculos/diagnóstico , Cálculos Renais/diagnóstico , Pelve Renal , Hepatopatias/diagnóstico , Adulto , Erros de Diagnóstico , Feminino , Humanos
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