RESUMO
Brucellosis is a rare disease in Denmark. We describe one case of laboratory-acquired brucellosis from an index patient to a laboratory technician following exposure to an infected blood culture in a clinical microbiology laboratory.
Assuntos
Brucelose/transmissão , Infecção Laboratorial/transmissão , Adulto , Brucella melitensis/isolamento & purificação , Feminino , Humanos , Infecção Laboratorial/microbiologia , Infecção Laboratorial/prevenção & controle , MasculinoRESUMO
The laboratory diagnosis of Lyme disease in Denmark is reviewed with recommendations for serological testing. In Denmark the laboratory testing is performed with an ELISA technique. Most laboratories use an assay based on purified flagella antigen. The two-tier approach with Western Blot as confirmatory testing is not recommended since the contribution to the diagnostic specificity is only marginal. Predictive values of Lyme serology are presented, based on the estimated prevalence of the different stages of Lyme disease in Denmark.
Assuntos
Doença de Lyme/diagnóstico , Anticorpos Antibacterianos/biossíntese , Western Blotting , Borrelia burgdorferi/genética , Borrelia burgdorferi/imunologia , Ensaio de Imunoadsorção Enzimática , Humanos , Doença de Lyme/imunologia , Doença de Lyme/microbiologia , Neuroborreliose de Lyme/diagnóstico , Neuroborreliose de Lyme/imunologia , Testes SorológicosAssuntos
Lipoproteínas , Doença de Lyme/epidemiologia , Neuroborreliose de Lyme/epidemiologia , Animais , Antibacterianos/administração & dosagem , Anticorpos Antibacterianos/análise , Antígenos de Superfície/administração & dosagem , Proteínas da Membrana Bacteriana Externa/administração & dosagem , Vacinas Bacterianas , Borrelia burgdorferi/imunologia , Ceftriaxona/administração & dosagem , Dinamarca/epidemiologia , Vetores de Doenças , Doxiciclina/administração & dosagem , Humanos , Doença de Lyme/diagnóstico , Doença de Lyme/tratamento farmacológico , Doença de Lyme/imunologia , Vacinas contra Doença de Lyme/administração & dosagem , Neuroborreliose de Lyme/diagnóstico , Neuroborreliose de Lyme/tratamento farmacológico , Neuroborreliose de Lyme/imunologia , Penicilinas/administração & dosagemRESUMO
INTRODUCTION: Mycoplasma pneumoniae is a common cause of atypical pneumonia in children and young adults. The infection is generally mild and only a very few patients are admitted to hospital. However, extrapulmonary complications are well recognised--mostly as manifestations from the central nervous system (CNS). MATERIAL AND METHODS: We describe 21 patients with M. pneumoniae infection seen at Rigshospitalet, Copenhagen, from 1994 to 2000. RESULTS: The patients had fever, headache, myalgia, and cough. Biochemically, they were characterised by leucocytosis, an increased level of C-reactive protein, and infiltrations on the chest x-ray. A total of seven patients developed extrapulmonary complications to the infection in the form of encephalitis (3), polyradiculitis (1), transversel myelitis (1), erythema multiforme (3), cardial arrhythmia (1), and haemolytic anaemia (2). Three patients had more than one complication at the same time. DISCUSSION: The incidence of patients with complications to M. pneumoniae infection was higher than that reported in the literature, probably because these patients are typically submitted to the Department of Infectious Diseases, Rigshospitalet. The pathogenesis of extrapulmonary complications to M. pneumoniae infection is unknown.