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Elife ; 82019 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-31825307

RESUMO

Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer's disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.


Assuntos
Cognição/fisiologia , Ciência dos Animais de Laboratório/instrumentação , Ciência dos Animais de Laboratório/métodos , Roedores , Doença de Alzheimer , Animais , Comportamento Animal , Comportamento de Escolha , Bases de Dados Factuais , Modelos Animais de Doenças , Feminino , Aprendizagem/fisiologia , Masculino , Memória/fisiologia , Camundongos , Testes Neuropsicológicos , Reprodutibilidade dos Testes , Roedores/genética , Software
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