RESUMO
OBJECTIVES: To determine the long-term oncological outcome of organ-confined (Assuntos
Assistência ao Convalescente/normas
, Carcinoma de Células Renais/cirurgia
, Neoplasias Renais/cirurgia
, Recidiva Local de Neoplasia/epidemiologia
, Nefrectomia
, Idoso
, Idoso de 80 Anos ou mais
, Neoplasias Ósseas/epidemiologia
, Neoplasias Ósseas/secundário
, Carcinoma de Células Renais/epidemiologia
, Carcinoma de Células Renais/secundário
, Progressão da Doença
, Feminino
, Seguimentos
, Humanos
, Incidência
, Estimativa de Kaplan-Meier
, Neoplasias Renais/mortalidade
, Neoplasias Renais/patologia
, Expectativa de Vida
, Neoplasias Pulmonares/epidemiologia
, Neoplasias Pulmonares/secundário
, Masculino
, Pessoa de Meia-Idade
, Recidiva Local de Neoplasia/patologia
, Estadiamento de Neoplasias
, Guias de Prática Clínica como Assunto
, Estudos Retrospectivos
, Fatores de Tempo
RESUMO
INTRODUCTION: The study aimed to compare the incidence of cardiovascular events (CVEs) after donor nephrectomy (DN) and radical tumor nephrectomy (RN), according to an estimated glomerular filtration rate (eGFR), were evaluated over time. MATERIALS AND METHODS: Follow-up was collected for DN who underwent surgery from 1998 to 2007 for CVE and renal function. All DN were matched for age to patients treated by RN or adenoma enucleation (control group), who were eligible for DN. eGFR was estimated using the Cockgroft-Gould formula. Patients with preoperative comorbidities were excluded. RESULTS: Thirty DN (median age 48.9 years) were included with a median follow-up of 138.5 months (interquartile range 119-159). No significant differences in patients' characteristics were found preoperatively (p > 0.5). Four out of 30 DN developed a CVE (3 myocardial infarctions (MI), 1 stroke), 2 of 30 patients in the control group (both MI) and 8 of 30 RN patients (6 MI, 2 strokes, p > 0.05). Arterial hypertension developed in 14 DN (46.7%), in 12 (40%) after RN and in 15 controls. The CVE occurred after a median time of 68 months (5-231) and were related to a drop of â¼30% in the eGFR irrespective of the group. CONCLUSION: Decline of renal function after nephrectomy is the main risk factor for CVE. Close monitoring of renal function and new onset hypertension is warranted.