Profiles of substance use related protective and risk factors and their associations with alcohol and tobacco use initiation among black adolescents.

Insufficient attention to protective and risk factors of particular salience for Black youth (e.g., racial identity and racial discrimination) in population-based substance use studies has left gaps in our understanding of alcohol and tobacco use development in Black adolescents. The current study aimed to capture the clustering of such understudied factors and their collective influence on alcohol and tobacco use initiation among Black adolescents. Data were drawn from The National Survey of American Life (n = 1,170; age range = 13-17; 6.9% Afro Caribbean, 93.1% African American; 50.0% female). Latent profile analysis applied to 11 indicators representing family, community, and individual level protective and risk factors revealed (1) High Vulnerability (high risk, low protective factors; 17.5%), (2) Moderate Vulnerability (moderate on both; 63.2%), and (3) Low Vulnerability (high protective, low risk factors; 19.3%) classes. Classes differed significantly by religious community support, school bonding, quality of relationship with mother, religious involvement, and interpersonal trauma. Relative to Class 2, Class 1 had higher odds of alcohol (OR = 1.518, CI:1.092-2.109) and tobacco use (OR = 1.998, CI:1.401-2.848); Class 3 had lower odds of alcohol (OR = 0.659, CI:0.449-0.968) but not tobacco use (OR = 0.965, CI:0.611-1.523). Findings suggest that alcohol and tobacco use initiation among Black adolescents is shaped by the collective influence of community and family level support, with commonly experienced risk factors such as non-interpersonal trauma distinguishing liability to a lesser degree. The equally modest prevalence of tobacco use among low and moderate vulnerability classes further indicates that fostering these connections may be especially effective in reducing tobacco use risk.

Treatment modality and outcomes in larynx cancer patients: A sex-based evaluation.

BACKGROUND: To evaluate the differences in treatment modality and outcomes between male and female patients with laryngeal squamous cell carcinoma (SCC) in the United States. METHODS: Data were extracted from the Surveillance, Epidemiology, and End Results Database for patients with laryngeal SCC (2004-2013). Overall survival (OS), disease specific survival (DSS), and multivariate analyses were conducted. RESULTS: Among women, supraglottic cancers were the most prevalent (61.2%); whereas the majority of men developed glottic cancers (64.2%; P < .001). Women with T4 disease were more likely to undergo primary radiation (56.8% vs 45.3%; P < .001) and less likely to undergo open surgery were than men (37.1% vs 48.2%; P < .001). Women had significantly better OS in glottic and supraglottic cancers, and comparable survival in subglottic cancer. Sex remained an independent prognostic factor for both DSS and OS. CONCLUSION: Sex is an independent prognostic factor for DSS and OS in patients with laryngeal SCC.

Evaluation of an Experiential and Self-Learning Approach to Teaching Evidence-Based Decision Making to Dental Students.

The aim of this study was to evaluate the impact on predoctoral dental students of an experiential and self-learning pedagogical approach to evidence-based decision making. Dental students at one U.S. dental school in 2014 and 2015 participated in an evidence-based decision making course that consisted of minimal lecturing, learning through assigned readings and open-book online quizzes, and individual assignments to reach an evidence-based decision on a clinically relevant question. Before and after the course, each cohort completed a validated survey assessing students' knowledge, attitudes, access of evidence, and confidence related to evidence-based practice. In 2014, of 43 students enrolled in the course, all 43 (100%) completed the pre-course survey, and 33 (77%) completed the post-course survey. In 2015, of 35 students enrolled in the course, all 35 (100%) completed the pre-course survey, and 34 (97%) completed the post-course survey. Of those, the identifier codes for 23 students in 2014 and 25 students in 2015 matched for the pre-course and post-course surveys, allowing direct comparisons. Both cohorts of students showed a significant increase in knowledge regarding critical appraisal of the literature from the pre-course survey results to after the course (p<0.001). Students' reported frequency of accessing evidence from various sources also significantly increased from before to after the course for both cohorts (p<0.01). Students' confidence in evaluating various aspects of a published research report also increased significantly from before to after the course for both cohorts (p<0.001). However, no consistent change was found in students' attitudes about evidence-based practice. In this study, an experiential and self-learning approach to teaching evidence-based decision making in the classroom appeared to be successful in improving students' knowledge, use of evidence, and confidence in critical appraisal skills, though it did not have a consistent impact on their attitudes about evidence-based practice.

The second life of Kowloon Walled City: Crime, media and cultural memory.

Kowloon Walled City (hereafter KWC or Walled City), Hong Kong has been described as 'one of history's great anomalies'. The territory remained under Chinese rule throughout the period of British colonialism, with neither jurisdiction wishing to take active responsibility for its administration. In the postwar period, the area became notorious for vice, drugs and unsanitary living conditions, yet also attracted the attention of artists, photographers and writers, who viewed it as an instance of anarchic urbanism. Despite its demolition in 1993, KWC has continued to capture the imaginations of successive generations across Asia. Drawing on data from an oral and visual history project on the enclave, alongside images, interviews and observations regarding the 'second life' of KWC, this article will trace the unique flow of meanings and reimaginings that KWC has inspired. The article will locate the peculiar collisions of crime and consumerism prompted by KWC within the broader contexts in which they are embedded, seeking out a new interdisciplinary perspective that attends to the internecine spaces of crime, media and culture in contemporary Asian societies.

Does the model of hierarchical complexity produce significant gaps between orders and are the orders equally spaced?

The model of hierarchical complexity (MHC) provides an analytic a priori measurement of the difficulty of tasks. As part of the theory of measurement in mathematical psychology, the model of hierarchical complexity (Commons and Pekker, 2008) defines a new kind of scale. It is important to note that the orders of hierarchical complexity of tasks are postulated to form an ordinal scale. A formal definition of the model of hierarchical complexity is presented along with the descriptions of its five axioms that help determine how the model of hierarchical complexity orders actions to form a hierarchy. The fourth and the fifth axioms are of particular importance in establishing that the orders of hierarchical complexity form an equally spaced ordinal scale. Previously, it was shown that Rasch-scaled items followed the same sequence as their orders of hierarchical complexity. Here, it is shown that the gaps between the highest Rasch scaled item scores at a lower order and the lowest scores at the next higher order exist. We found there was no overlap between the Rasch-scaled item scores at one order of complexity, and those of the adjoining orders. There are 'gaps' between the stages of performance on those items. Second, we tested for equal spacing between the orders of hierarchical complexity. We found that the orders of hierarchical complexity were equally spaced. To deviate significantly from the data, the orders had to deviate from linearity by over .25 of an order. This would appear to be an empirical and mathematical confirmation for the equally spaced stages of development.

Forensic experts' perceptions of expert bias.

How do expert witnesses perceive the possible biases of their fellow expert witnesses? Participants, who were attendees at a workshop at the American Academy of Psychiatry and Law were asked to rate for their biasing potential a number of situations that might affect the behavior of an opposing expert. A Rasch analysis produced a linear scale as to the perceived biasing potential of these different kinds of situations from the most biasing to the least biasing. Working for only one side in both civil and criminal cases had large scaled values and also were the first factor. In interesting contrast, a) an opposing expert also serving as the litigant's treater and b) an opposing expert being viewed as a "hired gun" (supplying an opinion only for money) were two situations viewed as not very biasing. Order of Hierarchical Complexity also accounted for items from the 1st, 2nd and 3rd factors. The result suggests that the difficulty in understanding the conceptual basis of bias underlies the perception of how biased a behavior or a situation is. The more difficult to understand the questionnaire item, the less biasing its behavior or situation is perceived by participants.

MaConDa: a publicly accessible mass spectrometry contaminants database.

UNLABELLED: Mass spectrometry is widely used in bioanalysis, including the fields of metabolomics and proteomics, to simultaneously measure large numbers of molecules in complex biological samples. Contaminants routinely occur within these samples, for example, originating from the solvents or plasticware. Identification of these contaminants is crucial to enable their removal before data analysis, in particular to maintain the validity of conclusions drawn from uni- and multivariate statistical analyses. Although efforts have been made to report contaminants within mass spectra, this information is fragmented and its accessibility is relatively limited. In response to the needs of the bioanalytical community, here we report the creation of an extensive manually well-annotated database of currently known small molecule contaminants. AVAILABILITY: The Mass spectrometry Contaminants Database (MaConDa) is freely available and accessible through all major browsers or by using the MaConDa web service http://www.maconda.bham.ac.uk.

Changes in the Chinese overseas population, 1955 to 2007.

Two approaches have been adopted to study Chinese overseas. The first one stresses homeland ties and sojourning mentality; the second one focuses on host society conditions and the social construction of Chinese. This paper analyzes the population of Chinese overseas after the Second World War, which has increased steadily over time but unevenly by region from 11 million in 1955 to 39 million in 2007. Certain historical factors and contemporary forces explain the uneven growth. The paper argues that undue emphasis on homeland influence is unwarranted in view of the importance of how receiving society and its policy of accommodation have shaped the growth and development of Chinese overseas communities after the Second World War.

Aberraciones cromosómicas in vitro para evaluar genotoxicidad de extractos de Abuta grandifolia (abuta) y Alchornea castaneifolia (hiporuro) / In vitro chromosome aberration analysis to evaluate genotoxicity of extracts of Abuta grandifolia (abuta) and Alchornea castaneifolia (hiporuro)

La evaluación de plantas medicinales usando parámetros de genotoxicidad, nos permite indicar si alguno de sus componentes puede provocar daño al material genético, a niveles génico o cromosómico. Este daño puede estimarse y determinará si el uso de la planta es conveniente o si por el contrario, el efecto benéfico aludido, se ve opacado por el probable efecto genotóxico. De forma alternativa, esta misma metodología permitiría detectar el efecto protector de una planta frente a la acción de mutágenos, lo cual redundaría en beneficio de los usuarios. Objetivo: Evaluar, in vitro, el efecto genotóxico del extractos de Abuta grandifolia, ôAbutaõ y Alchornea castaneifolia, ôHiporuroõ. Materiales y método: se realizaron cultivos de linfocitos obtenidos de sangre periférica, agregando los extractos de Abuta grandifolia, ôAbutaõ y Alchornea castaneifolia, ôHiporuroõ a diferentes concentraciones. Posteriormente, se realizó la evaluación citológica de aberraciones cromosómicas. Resultados: Se encontró un número elevado de aberraciones cromosómicas, tanto para el cultivo con Abuta como para el de Hiporuro. Este efecto se observó a diferentes concentraciones de extracto. Conclusiones: Las aberraciones cromosómicas encontradas en el presente trabajo, implicarían un efecto genotóxico de ambas plantas medicinales en el sistema in vitro empleado. Se requiere más estudios a diferentes niveles de organización que complementen los resultados reportados de este trabajo.

The evaluation of plants used in traditional medicine base don genotoxic parameters, allows researchers to determinate if some component could promote, genetic or chromosomal damage. This damage can be measured and, allow to determine the convenience of its use or, on the contrary, if its beneficial effect in undermined by the genotoxic effect. Moreover, this method would make it possible to detect the protective effect of the plant as opposed to a mutagen, which would enhance the benefit of its use. Objective: To evaluate the genotoxic effect of extracts of Abuta grandifolia, ôAbutaõ and Alchornea castaneifolia, ôHiporuroõ, using an in vitro test. Materials and method: Lymphocytes were cultured from peripheral blood, adding Abuta or Hiporuro extracts in different doses. Cytological evaluation of chromosome aberration was performed and registered. Results: An increased number of chromosome aberrations in Abuta and Hiporuro culture were found for different doses of extract. Conclusions: Chromosome aberrations found in the present work, would implicate a genotoxic effect in both plants in the system used. More studies are needed to complement the results of this research.