Effect of evodiamine on cell death pathways in human gastric cancer cells.

Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.

A Novel Change Detection Method Based on Statistical Distribution Characteristics Using Multi-Temporal PolSAR Data.

Unsupervised change detection approaches, which are relatively straightforward and easy to implement and interpret, and which require no human intervention, are widely used in change detection. Polarimetric synthetic aperture radar (PolSAR), which has an all-weather response capability with increased polarimetric information, is a key tool for change detection. However, for PolSAR data, inadequate evaluation of the difference image (DI) map makes the threshold-based algorithms incompatible with the true distribution model, which causes the change detection results to be ineffective and inaccurate. In this paper, to solve these problems, we focus on the generation of the DI map and the selection of the optimal threshold. An omnibus test statistic is used to generate the DI map from multi-temporal PolSAR images, and an improved Kittler and Illingworth algorithm based on either Weibull or gamma distribution is used to obtain the optimal threshold for generating the change detection map. Multi-temporal PolSAR data obtained by the Radarsat-2 sensor over Wuhan in China are used to verify the efficiency of the proposed method. The experimental results using our approach obtained the best performance in East Lake and Yanxi Lake regions with false alarm rates of 1.59% and 1.80%, total errors of 2.73% and 4.33%, overall accuracy of 97.27% and 95.67%, and Kappa coefficients of 0.6486 and 0.6275, respectively. Our results demonstrated that the proposed method is more suitable than the other compared methods for multi-temporal PolSAR data, and it can obtain both effective and accurate results.

A PolSAR Image Segmentation Algorithm Based on Scattering Characteristics and the Revised Wishart Distance.

A novel segmentation algorithm for polarimetric synthetic aperture radar (PolSAR) images is proposed in this paper. The method is composed of two essential components: a merging order and a merging predicate. The similarity measured by the complex-kind Hotelling⁻Lawley trace (HLT) statistic is used to decide the merging order. The merging predicate is determined by the scattering characteristics and the revised Wishart distance between adjacent pixels, which can greatly improve the performance in speckle suppression and detail preservation. A postprocessing step is applied to obtain a satisfactory result after the merging operation. The decomposition and merging processes are iteratively executed until the termination criterion is met. The superiority of the proposed method was verified with experiments on two RADARSAT-2 PolSAR images and a Gaofen-3 PolSAR image, which demonstrated that the proposed method can obtain more accurate segmentation results and shows a better performance in speckle suppression and detail preservation than the other algorithms.

Polarimetric Calibration and Quality Assessment of the GF-3 Satellite Images.

The GaoFen-3 (GF-3) satellite is the first fully polarimetric synthetic aperture radar (SAR) satellite designed for civil use in China. The satellite operates in the C-band and has 12 imaging modes for various applications. Three fully polarimetric SAR (PolSAR) imaging modes are provided with a resolution of up to 8 m. Although polarimetric calibration (PolCAL) of the SAR system is periodically undertaken, there is still some residual distortion in the images. In order to assess the polarimetric accuracy of this satellite and improve the image quality, we analyzed the polarimetric distortion errors and performed a PolCAL experiment based on scattering properties and corner reflectors. The experiment indicates that the GF-3 images can meet the satellite's polarimetric accuracy requirements, i.e., a channel imbalance of 0.5 dB in amplitude and ±10 degrees in phase and a crosstalk accuracy of -35 dB. However, some images still contain residual polarimetric distortion. The experiment also shows that the residual errors of the GF-3 standard images can be diminished after further PolCAL, with a channel imbalance of 0.26 dB in amplitude and ±0.2 degrees in phase and a crosstalk accuracy of -42 dB.

Multiframe image super-resolution adapted with local spatial information.

Super-resolution image reconstruction, which has been a hot research topic in recent years, is a process to reconstruct high-resolution images from shifted, low-resolution, degraded observations. Among the available reconstruction frameworks, the maximum a posteriori (MAP) model is widely used. However, existing methods usually employ a fixed prior item and regularization parameter for the entire HR image, ignoring local spatially adaptive properties, and the large computation load caused by the solution of the large-scale ill-posed problem is another issue to be noted. In this paper, a block-based local spatially adaptive reconstruction algorithm is proposed. To reduce the large computation load and realize the local spatially adaptive process of the prior model and regularization parameter, first the target image is divided into several same-sized blocks and the structure tensor is used to analyze the local spatial properties of each block. Different property prior items and regularization parameters are then applied adaptively to different properties' blocks. Experimental results show that the proposed method achieves better performance than methods with a fixed prior item and regularization parameter.

Assessment of spatial distribution of soil loss over the upper basin of Miyun reservoir in China based on RS and GIS techniques.

Soil conservation planning often requires estimates of the spatial distribution of soil erosion at a catchment or regional scale. This paper applied the Revised Universal Soil Loss Equation (RUSLE) to investigate the spatial distribution of annual soil loss over the upper basin of Miyun reservoir in China. Among the soil erosion factors, which are rainfall erosivity (R), soil erodibility (K), slope length (L), slope steepness (S), vegetation cover (C), and support practice factor (P), the vegetative cover or C factor, which represents the effects of vegetation canopy and ground covers in reducing soil loss, has been one of the most difficult to estimate over broad geographic areas. In this paper, the C factor was estimated based on back propagation neural network and the results were compared with the values measured in the field. The correlation coefficient (r) obtained was 0.929. Then the C factor and the other factors were used as the input to RUSLE model. By integrating the six factor maps in geographical information system (GIS) through pixel-based computing, the spatial distribution of soil loss over the upper basin of Miyun reservoir was obtained. The results showed that the annual average soil loss for the upper basin of Miyun reservoir was 9.86 t ha(-1) ya(-1) in 2005, and the area of 46.61 km(2) (0.3%) experiences extremely severe erosion risk, which needs suitable conservation measures to be adopted on a priority basis. The spatial distribution of erosion risk classes was 66.9% very low, 21.89% low, 6.18% moderate, 2.89% severe, and 1.84% very severe. Thus, by using RUSLE in a GIS environment, the spatial distribution of water erosion can be obtained and the regions which susceptible to water erosion and need immediate soil conservation planning and application over the upper watershed of Miyun reservoir in China can be identified.

Adaptive multiple-frame image super-resolution based on U-curve.

Image super-resolution (SR) reconstruction has been a hot research topic in recent years. This technique allows the recovery of a high-resolution (HR) image from several low-resolution (LR) images that are noisy, blurred and down-sampled. Among the available reconstruction frameworks, the maximum a posteriori (MAP) model is widely used. In this model, the regularization parameter plays an important role. If the parameter is too small, the noise will not be effectively restrained; conversely, the reconstruction result will become blurry. Therefore, how to adaptively select the optimal regularization parameter has been widely discussed. In this paper, we propose an adaptive MAP reconstruction method based upon a U-curve. To determine the regularization parameter, a U-curve function is first constructed using the data fidelity term and prior term, and then the left maximum curvature point of the curve is regarded as the optimal parameter. The proposed algorithm is tested on both simulated and actual data. Experimental results show the effectiveness and robustness of this method, both in its visual effects and in quantitative terms.

Local variance-controlled forward-and-backward diffusion for image enhancement and noise reduction.

In order to improve signal-to-noise ratio (SNR) and contrast-to-noise ratio, this paper introduces a local variance-controlled forward-and-backward (LVCFAB) diffusion algorithm for edge enhancement and noise reduction. In our algorithm, an alternative FAB diffusion algorithm is proposed. The results for the alternative FAB algorithm show better algorithm behavior than other existing diffusion FAB approaches. Furthermore, two distinct discontinuity measures and the alternative FAB diffusion are incorporated into a LVCFAB diffusion algorithm, where the joint use of the two measures leads to a complementary effect for preserving edge features in digital images. This LVC mechanism adaptively modifies the degree of diffusion at any image location and is dependent on both local gradient and inhomogeneity. Qualitative experiments, based on general digital images and magnetic resonance images, show significant improvements when the LVCFAB diffusion algorithm is used versus the existing anisotropic diffusion and the previous FAB diffusion algorithms for enhancing edge features and improving image contrast. Quantitative analyses, based on peak SNR, confirm the superiority of the proposed LVCFAB diffusion algorithm.

A MAP approach for joint motion estimation, segmentation, and super resolution.

Super resolution image reconstruction allows the recovery of a high-resolution (HR) image from several low-resolution images that are noisy, blurred, and down sampled. In this paper, we present a joint formulation for a complex super-resolution problem in which the scenes contain multiple independently moving objects. This formulation is built upon the maximum a posteriori (MAP) framework, which judiciously combines motion estimation, segmentation, and super resolution together. A cyclic coordinate descent optimization procedure is used to solve the MAP formulation, in which the motion fields, segmentation fields, and HR images are found in an alternate manner given the two others, respectively. Specifically, the gradient-based methods are employed to solve the HR image and motion fields, and an iterated conditional mode optimization method to obtain the segmentation fields. The proposed algorithm has been tested using a synthetic image sequence, the "Mobile and Calendar" sequence, and the original "Motorcycle and Car" sequence. The experiment results and error analyses verify the efficacy of this algorithm.