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Circ Arrhythm Electrophysiol ; 12(11): e007499, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31707807

RESUMO

BACKGROUND: There is increasing evidence that endurance exercise is associated with increased risk of atrial fibrillation (AF). However, it is unknown if the relationship between endurance exercise and AF is dependent on an atrial myopathy. METHODS: Six cardiac-specific TGF (transforming growth factor)-ß1 transgenic and 6 wild-type (WT) goats were utilized for these studies. Pacemakers were implanted in all animals for continuous arrhythmia monitoring and AF inducibility. AF inducibility was evaluated using 5 separate 10 s bursts of atrial pacing (160-200 ms). Three months of progressive endurance exercise (up to 90 minutes at 4.5 mph) was performed. Quantitative assessment of circulating microRNAs and inflammatory biomarkers was performed. RESULTS: Sustained AF (≥30 s) was induced with 10 s of atrial pacing in 4 out of 6 transgenic goats compared with 0 out of 6 WT controls at baseline (P<0.05). No spontaneous AF was observed at baseline. Interestingly, between 2 and 3 months of exercise 3 out of 6 transgenic animals developed self-terminating spontaneous AF compared with 0 out of 6 WT animals (P<0.05). There was an increase in AF inducibility in both transgenic and WT animals during the first 2 months of exercise with partial normalization at 3 months (transgenic 67%; 100%; 83% versus WT 0%; 67%; 17%). These changes in AF susceptibility were associated with a decrease in circulating microRNA-21 and microRNA-29 during the first 2 months of exercise with partial normalization at 3 months in both transgenic and WT animals. Finally, MMP9 (matrix metallopeptidase 9) was increased during the second and third months of exercise training. CONCLUSIONS: This study demonstrates a novel transgenic goat model of cardiac fibrosis (TGF-ß1 overexpression) to demonstrate that endurance exercise in the setting of an underlying atrial myopathy increases the incidence of spontaneous AF. Furthermore, endurance exercise seems to increase inducible AF secondary to altered expression of key profibrotic biomarkers that is independent of the presence of an atrial myopathy.


Assuntos
Fibrilação Atrial/genética , Regulação da Expressão Gênica , Átrios do Coração/fisiopatologia , Doenças Musculares/etiologia , Condicionamento Físico Animal/métodos , Fator de Crescimento Transformador beta1/genética , Animais , Animais Geneticamente Modificados , Fibrilação Atrial/complicações , Fibrilação Atrial/metabolismo , Modelos Animais de Doenças , Ecocardiografia , Feminino , Cabras , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/metabolismo , Imuno-Histoquímica , Doenças Musculares/genética , Doenças Musculares/metabolismo , RNA/genética , Fator de Crescimento Transformador beta1/biossíntese
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