RESUMO
Organocatalysts displaying a network of cooperative hydrogen bonds (NCHB) have been employed in an enzyme-like manner for a direct, switchable synthesis of enantiopure hexahydropyrimidinones (HHPMs) or dihydropyrimidinones (DHPMs), which starts at a common, easily accessible α-ureidosulfone stage. The NCHB organocatalyst exploits all its potential as a pure hydrogen-bond biomimetic catalyst even in the presence of organic bases. This one-pot, diastereo- and enantioselective synthetic procedure has been proven to be robust, scalable, highly efficient, and environmentally benign. A straightforward and truly practical entry to enantiopure HHPMs is reported for the first time.
RESUMO
Spondylotic cervical mielopathy is a common complication in young patients with Cerebral Child Palsy with an important dystonic and athetoid component. Its surgical treatment is a challenge, due to elevate incidence of early faliure of the arthrodesis, both in anterior and posterior approaches. We report an historical review about the treatment of cervical mielopathy in this subgroup of patients and a clinical case in which we decided to realize decompression and arthtrodesis by a combined anterior and posterior approach, with lateral-mass screw placement, using botulinium toxin injections in the postoperative period, achieving a good clinical outcome.
Assuntos
Paralisia Cerebral/complicações , Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Compressão da Medula Espinal/cirurgia , Fusão Vertebral/métodos , Espondilose/cirurgia , Adulto , Parafusos Ósseos , Toxinas Botulínicas Tipo A/uso terapêutico , Paralisia Cerebral/tratamento farmacológico , Terapia Combinada , Discotomia/métodos , Feminino , Humanos , Laminectomia/métodos , Imageamento por Ressonância Magnética , Fármacos Neuromusculares/uso terapêutico , Compressão da Medula Espinal/etiologia , Fusão Vertebral/instrumentação , Osteofitose Vertebral/complicações , Osteofitose Vertebral/cirurgia , Espondilose/complicaçõesRESUMO
Pseudodiastrophic dysplasia is a distinct disorder that differs from diastrophic dysplasia on the basis of elbow and proximal interphalangeal joint dislocations, platyspondyly, and scoliosis. We report on a new patient with this rare skeletal dysplasia and two previously undescribed major malformations: omphalocele and complex heart defect.