RESUMO
Our aim is to investigate whether or not the breast cancer metastasis suppressor 1 (BRMS1) gene expression is directly linked to clinico-pathological features of breast cancer. Following a stringent inclusion and exclusion criteria, case-control studies with associations between BRMS1 and breast cancer were selected from articles obtained by way of searches conducted through an electronic database. All statistical analyses were performed with Stata 12.0 (Stata Corp, College Station, TX, U.S.A.). Ultimately, 1,263 patients with breast cancer were found in a meta-analysis retrieved from a total that included 12 studies. Results of our meta-analysis suggested that BRMS1 protein in breast cancer tissues was significantly lower in comparison with normal breast tissues (odds ratio, OR = 0.08, 95% confidence interval (CI) = 0.04-0.15). The BRMS1 protein in metastatic breast cancer tissue was decreased than from that was found in non-metastatic breast cancer tissue (OR = 0.20, 95%CI = 0.13-0.29), and BRMS1 protein in tumor-node-metastasis (TNM) stages 1 and 2 was found to be higher than TNM stages 3 and 4 (OR = 4.62, 95%CI = 2.77-7.70). BRMS1 protein in all three major types of breast cancer was lower than that of control tissues respectively. We also found strong correlations between BRMS1 mRNA levels and TNM stage and tumor size. The results our meta-analysis showed that reduction in BRMS1 expression level was linked directly to clinico-pathological features of breast cancer significantly; therefore, suggesting the loss of expression or reduced levels of BRMS1 is potentially a strong indicator of the metastatic capacity of breast cancer with poor prognosis.
Assuntos
Biomarcadores Tumorais/genética , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Linfonodos/patologia , Proteínas Repressoras/genética , Estudos de Casos e Controles , Intervalos de Confiança , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Metástase Linfática , Estadiamento de Neoplasias , Razão de Chances , Prognóstico , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Estatística como AssuntoRESUMO
OBJECTIVE: Introduce the experience on 54 cases of laparoscopic hepatectomy-liver transection by curettage and aspiration (LTCA). METHODS: We used Peng multifunctional operative dissector (PMOD) to perform laparoscopic liver transection by curettage and aspiration. RESULTS: 52 patients underwent laparoscopic hepatectomy successfully. 2 patients were converted to an open hepatectomy for raw surface hemorrhage or severe abdominal cavity adherence. Mean operative time was 146.5 minutes, the mean bleeding volume was 460 mL, the largest excised liver size was 20 cm x 7 cm x 4 cm. Bile leakage and pneumothorax occurred in 2 patients. Patients could walk one day after operation and were discharged one week postoperatively. CONCLUSION: Laparoscopic hepatectomy by curettage and aspiration is a safe and effective technique. PMOD is an optimal tool to perform laparoscopic hepatectomy.
Assuntos
Hepatectomia/métodos , Laparoscopia , Adulto , Idoso , Carcinoma Hepatocelular/cirurgia , Curetagem , Feminino , Humanos , Neoplasias Hepáticas/cirurgia , Masculino , Pessoa de Meia-IdadeRESUMO
In this paper, we analyse the composition, structure and property of two kinds of slice materials by FTIR spectrometer, X-ray fluorometer and tension test device. Results show that: 1) K thin slice consists of PVC resin, plasticizer(15.5%) and a little additive. Its structures look like woollen blanket. Its property is good. 2) L thin slice consists of PVC resin, the plasticier (13.2%), CaCO3 (6.59%) and little additive. There is a little crack on its structure. On these bases, the rupture problem of thin slice is discussed by the theory of the freedom volume and of the boundary chemistry. Research shows that the keys to question are the composition of the thin slices and the quantity of plasticizer.