Evolution of the Magnetic Excitations in Electron-Doped La_{2-x}Ce_{x}CuO_{4}.

We investigated the high energy spin excitations in electron-doped La_{2-x}Ce_{x}CuO_{4}, a cuprate superconductor, by resonant inelastic x-ray scattering (RIXS) measurements. Efforts were paid to disentangle the paramagnon signal from non-spin-flip spectral weight mixing in the RIXS spectrum at Q_{∥}=(0.6π,0) and (0.9π,0) along the (1 0) direction. Our results show that, for doping level x from 0.07 to 0.185, the variation of the paramagnon excitation energy is marginal. We discuss the implication of our results in connection with the evolution of the electron correlation strength in this system.

Measurement of the toroidal radiation asymmetry during massive gas injection triggered disruptions on J-TEXT.

Disruptions have the potential to cause severe damage to large tokamaks like ITER. The mitigation of disruption damage is one of the essential issues for the tokamak. Massive gas injection (MGI) is a technique in which large amounts of a noble gas are injected into the plasma in order to safely radiate the plasma energy evenly over the entire plasma-facing wall. However, the radiated energy during the disruption triggered by massive gas injection is found to be toroidally asymmetric. In order to investigate the spatial and temporal structures of the radiation asymmetry, the radiated power diagnostics for the J-TEXT tokamak have been upgraded. The multi-channel arrays of absolute extreme ultraviolet photodiodes have been upgraded at four different toroidal positions to investigate the radiation asymmetries during massive gas injection. It is found that the toroidal asymmetry is associated with plasma properties and MGI induced MHD activities.

Vertical fast electron bremsstrahlung diagnostic on J-TEXT tokamak.

Fast electron bremsstrahlung (FEB) emission during Ohmic discharge experiments on the Joint Texas Experimental Tokamak (J-TEXT) has been measured by a recently developed vertical multi-channel FEB diagnostic based on CdZnTe detectors. There are 5 sight lines to observe the vertical emission of fast electrons at the high-field side with a spatial resolution of 5 cm. The FEB emission in the energy range of 30-300 keV can be measured. The generation of fast electrons accelerated by loop voltage has been confirmed during the early phase of discharge by analyzing the signals of FEB emission. The runaway electron beam instabilities have been observed with the FEB diagnostic on J-TEXT.

Design of a shattered pellet injection system on J-TEXT tokamak.

Disruptions have the possibility of causing severe wall damage to large tokamaks like ITER. The mitigation of disruption damage is essential to the safe operation of a large-scale tokamak. The shattered pellet injection (SPI) technique, which is regarded as the primary injection method for ITER, presents several advantages relative to massive gas injection, including more rapid particle delivery, higher total particle assimilation, and more centrally peaked particle deposition. A dedicated argon SPI system that focuses on disruption mitigation and runaway current dissipation has been designed for the Joint Texas Experimental Tokamak (J-TEXT). A refrigerator is used to form a single argon pellet at around 64 K. The pellet will be shaped with a 5 mm diameter and a 1.5-10 mm length. Helium gas at room temperature will be used as a propellant gas for pellet acceleration. The pellet can be injected with a speed of 150-300 m/s. The time interval between injection cycles is about 8 min. The pellet will be shattered at the edge of the plasma and then injected into the core of plasma. The first experiments of SPI fast shutdown and runaway current dissipation have been performed.

Factors associated with syphilis infection: a comprehensive analysis based on a case-control study.

This study aimed to comprehensively evaluate factors that influence the likelihood of syphilis infection from risk-taking behaviours and medical conditions. A retrospective case-control study was conducted by enrolling 664 syphilis inpatients (excluding 11 congenital syphilis patients) and 800 sex- and age-matched controls. Medical histories, clinical data and patient interview data were collected and subjected to logistic regression analyses. The prevalence of syphilis in the study population was 3·9% (675/17,304). By univariate analysis, syphilis infection was associated with migration between cities, marital status, smoking, reproductive history, hypertension, elevated blood urea nitrogen (BUN) and infection with hepatitis B virus (HBV) (P < 0·05). A high rate of syphilis-HBV co-infection was observed in HIV-negative patients and further research revealed an association between syphilis and specific HBV serological reactivity. Syphilis was also associated with the frequency, duration and status of tobacco use. Multivariate analysis indicated that syphilis infection was independently associated with migration between cities [adjusted odds ratio (aOR) 1·368, 95% confidence interval (CI) 1·048-1·785], current smoking (aOR 1·607, 95% CI 1·177-2·195), elevated BUN (aOR 1·782, 95% CI 1·188-2·673) and some serological patterns of HBV infection. To prevent the spread of infectious diseases, inpatients and blood donors should be tested for HIV, syphilis, HBV and HCV simultaneously.

Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis.

The aim of this study was to investigate the influence of ulinastatin (UTI) on high mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in acute lung injury (ALI) rats with sepsis caused by cecal ligation and puncture (CLP) surgery, as well as to examine the underlying biological mechanism. Thirty rats were randomly and evenly divided into sham (control), CLP, and CLP + UTI groups. Thirty minutes after the surgery, the rats in the CLP + UTI group received UTI via the caudal vein, while normal saline was administered to rats in the other groups. Blood, lung tissues, and bronchoalveolar lavage fluid (BALF) were collected at different time points (6, 12, 24, and 48 h) after surgery for determination of related indicators. Compared with the CLP group, rats in the CLP + UTI group exhibited higher seven day survival rates, less lung injury, and decreased HMGB1 expression in the lung tissue, serum, and BALF. In addition, the levels of TNF-α and IL-6 at 24 h in the CLP + UTI group were markedly lower than those in the CLP group. These results suggest that by deregulation, UTI might decrease the lung injury and increase the survival time of ALI rats by downregulating HMGB1 expression as well as by inhibiting TNF-α and IL-6 levels in serum and BALF.

Preparation and properties of antibacterial polyvinyl chloride.

BACKGROUND: Plastic products improve people's daily life, but microorganisms attaching to plastic product surfaces present health hazards. AIM: Our study aimed to design a new kind of antibacterial plastic products to promote a higher quality of life. MATERIALS AND METHODS: Antibacterial polyvinyl chloride (PVC) composites were prepared using melt-blending. The antibacterial properties, mechanical properties, and optical transparencies of the PVC composites containing either silver-doped glass or silver-doped zirconium phosphate were studied, and the dispersal of these antibacterial agents throughout the PVC was also observed using scanning electron microscopy. RESULTS: The results showed that the antibacterial agents were well-dispersed throughout the PVC matrix and that the antibacterial ratio of PVC-G against Escherichia coli and Staphylococcus aureus was over 99.0%, which was better than that of PVC-P. The antibacterial agents had little effect on the mechanical properties of the PVC; however, they decreased the optical transparency of PVC, and the transmittance of PVC-P was decreased by 28.3%. CONCLUSIONS: Our results indicate that such kinds of antibacterial PVC composites have great potential in a wide variety of safer plastic applications.

Reveals new lung adenocarcinoma cancer genes based on gene expression.

BACKGROUND: Lung adenocarcinoma (LAC) is the most common type of lung cancer, accounting for 30-35% of all cases. AIM: In this study we aim to predict potential genes and confirm pathways which are associated with LAC. MATERIALS AND METHODS: By using the meta-analysis method, GSE10072 and GSE 2514 datasets were merged to find potential genes and pathways which are associated with LAC. RESULTS: Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development. Further, we predicted genes including EGF-like domain might be the potential target genes for further study, such as NGX6, MUC17, and Nel. In addition, a number of genes that associated with axon guidance, focal adhesion, and complement and coagulation cascades pathway might be also involved in LAC in a direct or indirectly manner. CONCLUSIONS: Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development We anticipate numerous advances in LAC research in the coming years based on our meta-analysis.

A modified rat model for cannulation and collection of thoracic duct lymph.

Difficulty in collecting lymph samples in small animals has impeded studies on lymphatic function and lymph composition. Here we report a simple and effective modified rat model for thoracic duct lymph drainage where animals remain in full consciousness and have free movement and access to water and food over 12 hours. The operative procedure required approximately 30 minutes to perform. Mean lymph drainage was 0.71 +/- 0.33 ml/h, and protein concentration did not change significantly (mean 37 +/- 2.59 mg/ml) over the 12 hours. However, the number of lymphocytes fluctuated widely between 0.08 +/- 0.03 x 10(6)/ml and 12.17 +/- 6.58 x 10(6)/ml. This modified animal model of thoracic duct lymph collection avoids influences of lipid intake, general anesthesia, or limited activity of animals on experimental outcomes, and therefore more accurately reflects lymph flow and composition under normal physiological conditions.

Strong light-induced negative optical pressure arising from kinetic energy of conduction electrons in plasmon-type cavities.

We found that very strong negative optical pressure can be induced in plasmonic cavities by LC resonance. This interesting effect could be described qualitatively by a Lagrangian model which shows that the negative optical pressure is driven by the internal inductance and the kinetic energy of the conduction electrons. If the metal is replaced by perfect conductors, the optical pressure becomes much smaller and positive.

The transcription factor Pitx3 is a risk modifier for Parkinson's disease in a Chinese Han population.

BACKGROUND AND PURPOSE: The transcription factor Pitx3 plays a crucial role in the development and survival of midbrain dopaminergic (mDA) neurons, especially the mDA neurons in the substantia nigra pars compacta. The degeneration of these neurons is the pathological hallmark in Parkinson's disease (PD). Several polymorphisms of the Pitx3 gene have been linked with sporadic and early-onset forms of PD, but different studies have given conflicting or inconsistent findings. Amongst the polymorphisms studied, the single-nucleotide polymorphism (SNP) rs3758549, located in the promoter region of Pitx3 gene, is one of the most well-studied but also one of the most controversial. In order to explore the nature of this association in greater detail and in a new ethnic group, we carried out a case-control study of the SNP rs3758549. METHODS: A total of 316 patients with sporadic PD and 305 healthy controls, from two centers in mainland China, were analyzed in our study. The genotypes at rs3758549 were determined by PCR-restriction fragment length polymorphism analysis. And we also analyzed the association between genotype and phenotype. RESULT: Our data showed a significant association between the rs3758549 polymorphism and PD (P = 0.012, OR = 1.50, 95%CI: 1.15-1.96). Furthermore, allele T of SNP rs3758549 was significantly more frequent in early-onset PD than in healthy controls (P < 0.001). CONCLUSION: Our findings indicate that the SNP rs3758549 (C >T substitution) in the Pitx3 gene is a potential risk for sporadic PD, especially early-onset PD in Chinese Han population.

Induction of myocarditis lesions in Lewis rats by formalin-killed cells of group A Streptococcus.

The feasibility of inducing rheumatic myocarditis lesions in Lewis rats by immunization with formalin-killed group A Streptococcus was evaluated. The rats were divided into three groups. Group A was immunized by injecting formalin-killed group A Streptococcus suspended in complete Freund's adjuvant (CFA) into the hind-foot pads and repeat immunization was given 1 week later by subcutaneous injection into the belly. The rats were then sacrificed 3 weeks after the initial immunization. In group B, the rats received the same initial immunization as group A, but the repeat immunization was carried out at 1, 2 and 3 weeks after the initial immunization and the rats were sacrificed 6 weeks after the initial immunization. Group C was a control group with the rats injected with saline/CFA and sacrificed on the same schedule as group A. Heart pathology sections showed that myocarditis lesions, focal inflammatory cell infiltration in interstitial near small vessels and valvulitis were induced in Lewis rats following immunization with formalin-killed group A Streptococcus.

Longitudinal elliptically polarized electromagnetic waves in off-diagonal magnetoelectric split-ring composites.

We study the propagation of plane electromagnetic waves through different systems consisting of arrays of split rings of different orientations. Many extraordinary EM phenomena were discovered in such systems, contributed by the off-diagonal magnetoelectric susceptibilities. We find a mode such that the electric field becomes elliptically polarized with a component in the longitudinal direction (i.e. parallel to the wavevector). Even though the group velocity [Formula: see text] and the wavevector k are parallel, in the presence of damping, the Poynting vector does not just get 'broadened', but can possess a component perpendicular to the wavevector. The speed of light can be real even when the product 쵵 is negative. Other novel properties are explored.

Manipulating electromagnetic radiation with magnetic photonic crystals.

We examine manipulating electromagnetic waves in magnetic photonic crystals (MPCs) with external magnetic fields. We predict new giant magnetoreflectivity and giant magnetorefractivity effects: with an external magnetic field of a magnitude much smaller than the anisotropy field of the ferromagnet, the MPC can be changed from completely reflecting to nonreflecting with corresponding changes in the angle of refraction. Application to the storage of electromagnetic radiation is also discussed.

Probing states with macroscopic circulations in magnetic photonic crystals.

We predict that when light is reflected off a magnetic photonic crystal (MPC) there is a grazing component that is parallel to the surface; the magnitude of this component can be changed by an external field. The direction of this parallel component is reversed as the direction of the magnetization is reversed. This provides a way to probe states with macroscopic circulations inside the MPC.

Multilayer structures as negative refractive and left-handed materials.

We examine multilayer structures as negative refractive index and left-handed materials, and find that for one polarization there is a wide range (≈90°) of incident angle within which negative refraction will occur. This comes about because the group velocity and the Poynting vector have a large component parallel to the layers, no matter what the angle of incidence of the incoming radiation is. This behaviour in turn comes from the large anisotropy of the phase velocities. If one of the components is a ferromagnetic metal, the system can be a left-handed material above the ferromagnetic resonance frequency.

Development of quantitative structure activity relationships in toxicity prediction of complex mixtures.

AIM: To predict the toxicity of mixtures of halogenated benzenes (narcotics). METHODS: Acute toxicity test of single chemicals and mixtures was performed using Photobacterium phosphoreum. Partition coefficients of mixtures were calculated by a special equation. Quantitative structure-activity relationship (QSAR) studies were carried out based on results of toxicity tests, n-octanol/water partition coefficient (Kow), and partition coefficient of mixtures (Kmix). RESULTS: 1) There was a good relationship between toxicity and lgKow for single compounds. 2) QSAR analysis showed a perfect correlation between the calculated Kmix and the mixture toxicity for binary mixtures. 3) Using the QSAR model of binary mixtures, the toxicity of other related mixtures containing different composition and fraction was predicted very well. CONCLUSION: The toxicity of halogenated benzene mixtures (narcotics) was predicted by QSAR. This kind of study is helpful for assessing the toxicity of narcotic mixtures.

The optimal dose of hyperbaric tetracaine spinal anesthesia for cesarean section.

Seventy-five term parturients undergoing cesarean section were anesthetized with 9 mg, 12 mg, 15 mg and 18 mg of tetracaine in 1.5 cc of 10% using a standardized spinal anesthetic technique. The four groups were compared for their maximal spread of anesthesia, quality of analgesia, incidence of hypotension, mgs of ephedrine used to correct hypotension, and the Apgar scores of the infant. It was found that maximal segmental spread of analgesia for 9 mg. 12 mg and 15 mg groups were not different significant regardless of height or weight. But with the 18 mg-group there was significant excessive spread of analgesia. While there was no difference in maximal spread of analgesia, there was a progressive increase in good quality of analgesia with increasing dosages. There were 67%, 81%, 96%, 100% of the patients had good analgesia for their operation in the four respective group. The percentages of hypotension were significanly more in the 15 mg and 18 mg groups. However, we did not find the hypotension in the 15 mg and 18 mg group need more ephedrine to correct than the lower dosages. In addition, all babies had good Apgar scores and there was no statistical difference among the four groups.