The prevalence and predictive value of individual criteria for metabolic syndrome in schizophrenia: a Northern Finland 1966 Birth Cohort Study.

The metabolic syndrome (MetS) is associated with elevated risk of diabetes and cardiovascular morbidity. However, little is known of the sensitivity, specificity and predictive value of individual criteria in patients with schizophrenia. We studied the prevalence of MetS using the International Diabetes Federation (IDF) and adapted National Cholesterol Education Program (NCEP-ATPIII) criteria in the Northern Finland 1966 Birth Cohort population. In addition, the sensitivity, specificity and predictive values for individual criteria were determined. Both adapted NCEP-ATPIII and IDF criteria for MetS identified the same cases (29% of all schizophrenia patients). Among the IDF criteria, hypertriglyceridemia had the highest sensitivity, correctly identifying 77.8% of the patients. Reduced HDL cholesterol was the most specific criteria, with 95% specificity equalling a positive likelihood ratio of 9.78. Thus both the IDF and NCEP-ATPIII criteria may be equally useful in identifying MetS.

The effect of eating behavior on weight loss and maintenance during a lifestyle intervention.

OBJECTIVE: To investigate the effects of intensive counseling on eating behavior and weight loss and maintenance and their associations. METHODS: A randomized weight loss counseling intervention with follow-up of 18 months, conducted between 2002-2004 at Oulu University Hospital, Finland included obese adults (n=82, body mass index >27 kg/m(2)). Subjects were randomized into 1) intensive counseling and 2) short-term counseling. Forty-nine subjects who completed the study were included. Eating behavior was repeatedly assessed by the Three Factor Eating Questionnaire-18 and Binge Eating Scale. RESULTS: Eating behavior improved in both groups. Effect of counseling was -5.0+/-5.7 kg compared with -2.4+/-2.5 kg in the control group (p<0.05 between the groups) during the first 6 months. At 18 months the weight loss results were -2.6+/-6 kg and -0.7+/-3.5 kg, respectively (NS). Success in weight loss maintenance is associated with improved eating behavior (p<0.05). By contrast, failure in weight loss is associated with high scores of uncontrolled eating and binge eating symptoms at the baseline (p<0.05). CONCLUSIONS: Both intensive and short-term interventions improved eating behavior and weight loss but there was no difference between the two modes of intervention. The association between the improvement of eating behaviour and the success of weight loss suggests a causal relationship which however should be confirmed in a prospective study focusing specifically on this aspect.

A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study.

OBJECTIVE: Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with, e.g., cardiovascular disorders. One major risk factor for these disorders is the metabolic syndrome, which has been reported to have a higher frequency in schizophrenic patients. Our objective was to study the prevalence of metabolic syndrome in a population-based birth cohort. METHOD: The study sample consisted of 5613 members of the Northern Finland 1966 Birth Cohort who participated in the field study from 1997 to 1998. Subjects were divided into 4 diagnostic categories (DSM-III-R): (1) schizophrenia (N = 31), (2) other functional psychoses (N = 22), (3) nonpsychotic disorders (N = 105), and (4) no psychiatric hospital treatment (N = 5455, comparison group). Subjects were assessed for the presence of metabolic syndrome according to the criteria of the National Cholesterol Education Program. RESULTS: The prevalence of metabolic syndrome was higher in subjects with schizophrenia compared with the comparison group (19% vs. 6%, p = .010). The prevalence of metabolic syndrome in subjects with other psychoses was 5%. After controlling for sex, the results of logistic regression analysis showed that the risk of metabolic syndrome in schizophrenia was 3.7 (95% CI = 1.5 to 9.0). CONCLUSIONS: The high prevalence of metabolic syndrome in schizophrenia even at such a relatively young age underscores the need to select antipsychotic medications with no or little capability to induce metabolic side effects. Also, developing comprehensive efforts directed at controlling weight and diet and improving physical activity are needed.