[Effects of short-term hyperglycemia on the state of brain function in patients with neurological neoplasms]. / Vliianie kratkovremennoi giperglikemii na sostoianie funktsii golovnogo mozga neiroonkologicheskikh bol'nykh.

The paper is concerned with the results of investigation of the effect of short-term hyperglycemia on main cerebral functions in neuro-oncological patients. Clinical and paraclinical control in the course of investigation revealed insignificant and transient changes of the neurological status, ECG and investigated cerebral functions. In a lesser group of patients changes over time were unobserved. Taking into account good tolerance of short-term hyperglycemia and the results of its effective use in general oncology, one can recommend it as a modifier in radiation therapy of brain gliomas. Proceeding from the obtained experimental data on a similar tumor model as well as positive results of the use of short-term hyperglycemia in general oncology, its use appeared to be most effective after tumor irradiation. Taking into account a certain degree of unreliability of the method (catheterization of the subclavicular vein), requiring strict control on the part of medical personnel, the use of short-term hyperglycemia could be effectively implemented during large-fractionated irradiation of brain gliomas.

[Enhancement of ionizing radiation effects on transplantable cerebral gliomas using short-term hyperglycemia]. / Usilenie éffekta deistviia ioniziruiushchego izlucheniia na perevivnye gliomy golovnogo mozga posredstvom kratkovremennoi giperglikemii.

Experiments were staged on rats with transplantable anaplastic cerebral right hemisphere astrocytomas. Hyperglycemia was induced by means of intraperitoneal fractional administration of 40% glucose solution. Single local x-ray tumor irradiation followed on the 4-5th, 7-8th and 10-12th days after strain transplantation at the doses of 30 and 40 Gy without hyperglycemia and in combination with it. The irradiation effect was assessed by the mean survival time of the animals. Hyperglycemia was shown to increase significantly radiation injury of highly resistant experimental malignant cerebral glial tumors.

[Concentration of lactate concentration in experimental glial tumors and brain tissue during brief artificial hyperglycemia]. / Soderzhanie laktata v glial'nykh opukholiakh i mozgovoi tkani v éksperimente pri iskusstvennoi kratkovremennoi giperglikemii.

The authors studied the content of lactic acid in glial tumors of the brain and brain tissue of rats in short-term artificial hyperglycemia. In short-term artificial glycemia the lactic acid content in glial tumors of animals was almost twice the level of this metabolite in the brain tissue, which is due to the high potential rate of glucose consumption by the tumor and the increased glycolytic activity in it in these conditions. The lactate content in the glial brain tumors significantly increases when the sugar concentration in the blood of animals is artificially increased. It is suggested that accumulation of lactic acid in brain gliomas of experimental animals contributes to diminution of tumor cell viability, which will increase sensitivity of the tumor to irradiation.

[Concentration of glucose in the tissues of glial tumors of the brain in rats with artificial hyperglycemia of short duration]. / Soderzhanie gliukozy v tkaniakh glial'nykh opukholei golovnogo mozga krys pri iskusstvennoi kratkovremennoi giperglikemii.

The glucose content in the tissues of rat brain glial tumors and in the brain tissue during short-term induced hyperglycemia was studied. It was shown that in artificial increase of the concentration of glucose in blood, its content in the tumor grows sharply and exceeds considerably the level of this metabolite in the brain tissue. In distinction from the brain tissue, the tumor was marked by a high rate of glucose consumption and utilization under these conditions. It is concluded that brain glial tumors are also capable of increasing glucose consumption in artificial hyperglycemia. It is suggested the the accumulation of glucose by the tumor creates the preconditions for improving the efficacy of radiotherapy combined with short-term artificial hyperglycemia in the management of brain glial tumors.