A Symbiotic Meal Containing Extruded Sorghum and Probiotic (Bifidobacterium longum) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial.

BACKGROUND: Chronic kidney disease increases uremic toxins concentrations, which have been associated with intestinal dysbiosis. Sorghum bicolor L. Moench has dietary fiber and bioactive compounds, while Bifidobacterium longum can promote beneficial health effects. METHODS: It is a controlled, randomized, and single-blind clinical trial. Thirty-nine subjects were randomly separated into two groups: symbiotic group (SG), which received 100 mL of unfermented probiotic milk with Bifidobacterium longum strain and 40 g of extruded sorghum flakes; and the control group (CG), which received 100 mL of pasteurized milk and 40 g of extruded corn flakes for seven weeks. RESULTS: The uremic toxins decreased, and gastrointestinal symptoms improved intragroup in the SG group. The acetic, propionic, and butyric acid production increased intragroup in the SG group. Regarding α-diversity, the Chao1 index was enhanced in the SG intragroup. The KEGG analysis revealed that symbiotic meal increased the intragroup energy and amino sugar metabolism, in addition to enabling essential amino acid production and metabolism, sucrose degradation, and the biosynthesis of ribonucleotide metabolic pathways. CONCLUSIONS: The consumption of symbiotic meal reduced BMI, improved short-chain fatty acid (SCFA) synthesis and gastrointestinal symptoms, increased diversity according to the Chao1 index, and reduced uremic toxins in chronic kidney disease patients.

IgG4-related disease: Case report and 6-year follow-up of an elusive diagnosis mimicking malignancy.

Key Clinical Message: IgG4-related disease is a rare and emerging pathology, characterized by the appearance of pseudotumors. Due to the ability to mimic other pathologies, it is essential to consider it as a differential diagnosis in multisystemic processes. The diagnosis is challenging, requiring a multidisciplinary approach, to minimize the associated morbidity and mortality. Abstract: IgG4-related disease (IgG4-RD) is a rare, emerging, systemic and chronic pathology, characterized by the appearance of pseudotumors resulting from tissue infiltration by IgG4-positive plasma cells that promote eosinophilic inflammation of the tissue with subsequent fibrosis. We present the case of a male, 45-year-old patient, with marked weight loss and skin pallor detected by his family doctor during a child health consultation of his daughter. When questioned, the patient referred complaints of postprandial discomfort in the left hypochondrium with a feeling of fullness, weight loss, chronic fatigue and hyperhidrosis that had lasted for a month. On physical examination, he was pale, and had pain at palpation of the left hypochondrium. Laboratory data showed increased inflammation markers, abdominal ultrasound and CT demonstrated numerous enlarged lymph nodes in the upper quadrants, raising concern for a malignant lymphoproliferative process. Serological, imaging, clinical and laparoscopic excisional biopsy revealed features of IgG4-related disease and excluded malignant lymphoproliferative disease. The immediate response to treatment with oral prednisolone 30 mg/day also contributed for diagnosis confirmation. Due to refractory disease after gradual prednisolone reduction, second-line therapy with rituximab was initiated. Over the 6 years of follow-up, the patient presented multiple exacerbations characterized by the emergence of systemic symptoms, being maintained under close clinical and imaging follow-up by reumathology, infectious diseases, and family medicine specialists.

Desafios de profissionais no atendimento à diversidade de cuidadores de bebês na Atenção Básica / Challenges for professionals to assist the diversity of baby caregivers in Primary Care / Desafíos de los profesionales para atender la diversidad de cuidadores de bebés en Atención Primaria

INTRODUÇÃO: As políticas de saúde infantil da Atenção Básica preconizam pela perspectiva do cuidado integral, associadas ao princípio da territorialidade. Contudo, abarcar a diversidade do território constitui-se enquanto um importante desafio para os profissionais de saúde responsáveis pelas consultas periódicas dos bebês, sobretudo em locais com forte tradição cultural hegemônica. OBJETIVO: O presente estudo buscou investigar as experiências e desafios de profissionais de saúde com a diversidade de cuidadores, saberes e práticas de cuidado nos atendimentos a bebês de 0 a 2 anos na Atenção Básica de Caxias do Sul, RS. MÉTODO: Trata-se de um estudo qualitativo envolvendo entrevistas online com 12 profissionais de saúde de quatro UBS da cidade, cujos dados foram analisados através de uma leitura psicanalítica. RESULTADOS e DISCUSSÃO: Constatou-se que há uma diversidade de cuidadores nas consultas dos bebês, sobretudo mães italianas, avós italianas e cuidadores imigrantes não italianos. Ainda, as consultas acabam se tornando um palco de embates entre profissionais e cuidadores, especialmente no tocante às dissonâncias sobre os saberes e práticas de cuidado ao bebê. CONCLUSÃO: Os saberes dos cuidadores que não estão em consonância com as políticas de saúde são percebidos pelos profissionais de saúde enquanto desafios na efetivação do cuidado integral dos bebês.

INTRODUCTION: Child health policies in Primary Health Care (PHC) operate from the perspective of comprehensive care, associated with the principle of territoriality. However, embracing the diversity of the territory is an important challenge for health professionals responsible for the infant's periodic consultations, especially in territories with a strong hegemonic cultural tradition. OBJECTIVE: This study sought to investigate the experiences and challenges of health professionals with the diversity of caregivers, traditional knowledge, and care practices regarding infants aged 0 to 2 years in PHC, in a southern city of Brazil. METHOD: This qualitative study involved online interviews with 12 health professionals from four PHC Centers, whose data were analyzed through a psychoanalytical reading. RESULTS and DISCUSSION: It was found that there is a diversity of caregivers in the infant's consultations, especially Italian mothers, Italian grandmothers and non-Italian immigrant caregivers. Moreover, the consultations become a stage for disparities between professionals and caregivers, especially because of the disagreements about the traditional knowledge and baby care practices. CONCLUSIONS: The caregiver's traditional knowledge that differs from the health policies end up being perceived by health professionals as challenges in the achievement of comprehensive care for infants.

INTRODUCCIÓN: Las políticas de salud infantil en Atención Primaria abogan por prácticas profesionales basadas en la perspectiva de la atención integral, asociada al principio de territorialidad. Sin embargo, acoger la diversidad del territorio es un desafío para los profesionales de la salud responsables de las consultas periódicas con los bebés, especialmente en lugares con una fuerte tradición cultural hegemónica. OBJETIVO: Este estudio investigó las experiencias y desafíos de los profesionales de salud con la diversidad de cuidadores, saberes y prácticas de cuidado en consultas de bebés de 0 a 2 años, en Atención Primaria de una ciudad del sur de Brasil. MÉTODO: Se trata de una investigación cualitativa que involucra entrevistas online con 12 profesionales de cuatro centros de salud, cuyos datos fueron analizados a través de una lectura psicoanalítica. RESULTADOS y DISCUSSIÓN: Se encontró que existe diversidad de cuidadores, especialmente madres/abuelas italianas y cuidadoras inmigrantes no italianas. Las consultas se convierten en escenario de enfrentamientos entre profesionales y cuidadores en lo que se refiere a los diferentes conocimientos y prácticas del cuidado. CONCLUSIÓN: Los conocimientos de los cuidadores que no se ajustan a las políticas de salud acaban siendo percibidos por los profesionales como desafíos en la concreción de la atención integral al bebé.

Giant Intrathoracic Desmoid Tumor - a Case Report.

Desmoid tumors are soft tissue neoplasms arising from fascial and muscle-aponeurotic structure. These tumors are locally aggressive and have a high recurrence rate, even after complete resection. We present the case of a female with a giant intrathoracic desmoid tumor. She underwent complete surgical resection with no disease recurrence. Desmoid tumors' natural history is not well defined and is often enigmatic, making these tumors difficult to manage. Currently, for intrathoracic desmoid tumors, medical treatment is the recommended approach, nevertheless, surgery can be considered in selected patients.

Periprosthetic shoulder infection management: one-stage should be the way: a systematic review and meta-analysis.

BACKGROUND: There is still no consensus among surgeons on whether to perform a 1- or 2-stage surgical revision in infected shoulder arthroplasties. The aim of this systematic review and meta-analysis is to rigorously synthesize published studies evaluating the clinical outcomes, recurrence of infection, and other clinical complications in order to discuss which is the best strategy for treating periprosthetic joint infection after shoulder arthroplasty. METHODS: Upon research using the PubMed, Scopus, and Web of Science databases, in November 2022, studies that presented 1- or 2-stage surgical revision as a treatment for periprosthetic joint infection after shoulder arthroplasty and assessed the reinfection rate on these patients, as well as other clinical outcomes, with a minimum follow-up of 12 months, were included. Study quality was evaluated using the Methodological Index for Non-Randomized Studies (MINORS) score. Reinfection and complication rates were extracted, and pooled estimates were calculated using the random-effect model. RESULTS: After careful screening, 44 studies were included, 5 reporting on 1-stage and 30 on 2-stage revisions and 9 assessing both strategies. A total of 185 shoulders were reported in 1-stage revision studies, whereas 526 shoulders were reported in 2-stage revision studies. The overall pooled random-effects reinfection rate was 6.68% (95% confidence interval [CI]: 3.76-10.13), with low heterogeneity (I2 = 28%, P = .03). One-stage revision showed a reinfection rate of 1.14% (95% CI: 0.00-4.88), whereas 2-stage revision analysis revealed a reinfection rate of 8.81% (95% CI: 4.96-13.33). There were significant statistical differences between 1- and 2-stage reinfection rates (P = .04). The overall pooled rate for other clinical complications was 16.76% (95% CI: 9.49-25.15), with high heterogeneity (I2 = 70%, P < .01). One-stage revision had a complication rate of 6.11% (95% CI: 1.58-12.39), whereas the 2-stage revision complication rate was 21.26% (95% CI: 11.51-32.54). This difference was statistically significant (P = .03). CONCLUSIONS: This is the first systematic review and meta-analysis showing significant statistical differences between 1- and 2-stage surgical revision in infected shoulder arthroplasties. Provided the right conditions exist, 1-stage revision shows better results in infection control, with lower clinical complications and possible better clinical outcomes.

Função de Cuidar na Educação Infantil: Contribuições de Grupos de Discussão de Trabalho com Educadoras / Role of Caring in Early Childhood Education: Contributions from Working Discussion Groups with Educators / Función de Cuidado en la Educación Infantil: Grupos de Discusión de Trabajo con Maestros

As educadoras que atuam na Educação Infantil participam da subjetivação de bebês e crianças pequenas, o que pode ser extremamente exigente. Nesse sentido, este estudo teve como objetivo oferecer um espaço de escuta para educadoras, com vistas a refletir sobre os desafios da função de cuidar de bebês e crianças bem pequenas na Educação Infantil. Foram realizadas duas edições de um grupo de discussão de trabalho, nas quais participaram cinco educadoras. O material produzido no grupo de discussão de trabalho, juntamente com relatos discutidos em supervisão, foi analisado qualitativamente, a partir de análise temática indutiva. Os resultados evidenciam que o cuidado exige presença, previsibilidade, intimidade e sensibilidade, o que, muitas vezes, é solicitado pelos próprios bebês/crianças que convocam o adulto. Entretanto, responder a essas demandas de forma individualizada num ambiente coletivo pode trazer desconforto, mal-estar e angústia. O grupo de discussão de trabalho oportunizou às educadoras tomarem consciência de como se utilizavam, por vezes, de um estilo de cuidado mais mecanizado e controlador, de forma a se protegerem dessas demandas. Em síntese, o bebê/criança desacomoda o adulto e o convoca a (re)pensar sobre seu fazer, apontando a importância de espaços de escuta e reflexão aos profissionais da educação.

Working in Early Childhood Education implies that the adult caregiver participates in the subjectivation of babies, which can be extremely demanding. This study aimed to offer a listening space for nursery educators to reflect on the challenges of the role of caring for babies and very young children in Early Childhood Education. Two editions of the work discussion group were held, in which five educators participated. The material was qualitatively analyzed, considering the inductive thematic analysis. The results showed that care requires presence, predictability, intimacy, and sensitivity, requests often made by the babies and the children themselves who call the adult to respond from this place. However, responding to this demand individually in a collective environment can bring discomfort, malaise, and anguish. The group made it possible for educators to become aware of how they used a more mechanized and controlling style of care, to protect themselves from these demands. In summary, the baby and the children discomfort the adult and invite him/her to (re) think about his actions, pointing out the importance of spaces for listening and reflection to education professionals.

Trabajar en Educación Infantil implica que el adulto cuidador participe enlasubjetivación de los bebés, lo que puede ser extremadamente exigente. Por eso, este estudio tuvo como objetivo ofrecer un espacio de escucha a los educadores, con el fin de reflexionar sobre los retos del cuidado de los bebés y niños muy pequeños en la Educación Infantil. Se realizaron dos ediciones de los grupos de discusión de trabajo, en las que participaron cinco educadores. El material fue analizado cualitativamente, a partir del análisis temático inductivo. Los resultados muestran que el cuidado requiere presencia, previsibilidad, intimidad y sensibilidad, peticiones, muchas veces, realizadas por los propios bebés y niños que convocan al adulto. Sin embargo, responder a esta demanda de forma individual en un entorno colectivo puede traer malestar y angustia. Los grupos hizo posible que los educadores tomaran conciencia de cómo utilizaban un estilo de atención más mecanizado y controlador, para protegerse de estas demandas. En resumen, el bebé y los niños incomodan al adulto y lo invitan a (re) pensar en sus acciones, señalando la importancia de los espacios de escucha y reflexión de los profesionales de la educación.

Metabolic stability and metabolite profiling of emerging synthetic cathinones.

Synthetic cathinones constitute the second largest groups of new psychoactive substances (NPS), which are especially popular among adolescents and young adults. Due to their potential toxicity, the recreational use of these NPS constitute a serious worldwide public health problem. However, their fast appearance in the market renders the continuous updating of NPS information highly challenging for forensic authorities. The unavailability of pharmacokinetic data for emerging NPS is critical for forensic and clinical verifications. With the ultimate goal of having a proactive approach towards the NPS issue, high resolution mass spectrometry was used in the current work to assess preliminary pharmacokinetic data for 8 selected cathinones: 4 reported substances (4-CIC, 3-CMC, 4-CMC and 4-MEAP) and 4 previously unreported ones (3-CIC, 4-MDMB, 4-MNEB and 4-MDMP) for which the emergence on the NSP market is expected to be eminent, were also included in this study. Based on the calculation of pharmacokinetic parameters, half-life and intrinsic clearance, 4-CMC and 4-MDMB are low and high clearance compounds, respectively, and all the remaining cathinones included in this study are intermediate clearance compounds. This fact anticipates the key role of metabolites as suitable biomarkers to extend detection windows beyond those provided by the parent cathinones. Reduction of the keto group and hydroxylation on the alkyl chains were the common metabolic pathways identified for all cathinones. However, the relative importance of these metabolic transformations is dependent on the cathinone substituents. The glucuronic acid conjugation to metabolites stemming for keto group reduction constituted the sole Phase II transformation identified. To our knowledge, this study constitutes the first metabolite profiling of the already reported synthetic cathinones 4-CIC, 3-CMC and 4-CMC. Noteworthy is the fact that 3-CMC accounts for almost a quarter of the quantity of powders seized during 2020. The analytical methods developed, and the metabolites characterized, are now available to be included in routine screening methods to attest the consumption of the 8 cathinones studied.

"É um bombardeio de sentimentos": experiências maternas no contexto do nascimento prematuro / "It's an explosion of feelings": maternal experiences in the context of preterm birth / "Es un bombardeo de sentimientos": experiencias maternas en el contexto del parto prematuro

O presente estudo investigou a experiência da maternidade de mães de bebês nascidos extremamente prematuros durante suas hospitalizações na UTI Neo. Em particular, buscou-se conhecer os sentimentos maternos relacionados a esse contexto. Participaram 18 mães cujos bebês tinham entre 25 e 28 semanas gestacionais e pesavam entre 625g e 1000g. As mães foram entrevistas 15 dias após o parto e as respostas foram examinadas por meio de análise de conteúdo qualitativa. Foram desenvolvidos três eixos, derivados das entrevistas: sentimentos sobre a UTI Neo; sentimentos sobre as manifestações do bebê; e sentimentos sobre a maternidade. Os achados revelaram uma complexidade de sentimentos maternos no contexto da UTI Neo. Porém, destacaram-se nas verbalizações maternas o investimento narcísico das mães nos seus bebês, que as levavam a se comunicar com eles a partir de pequenos gestos e expressões sensoriais, o que oportunizava, simultaneamente, a construção de um lugar simbólico para o bebê. (AU)

The present study investigated the motherhood experience of mothers of extremely preterm infants during their hospitalizations in the NICU. In particular, we sought to investigate the maternal feelings related to this context. Participants included 18 mothers whose babies were between 25 and 28 gestational weeks and weighed between 625g and 1000g. Mothers were interviewed 15 days after delivery and the responses were examined using qualitative content analysis. Three axes were developed, derived from the interviews: feelings about the NICU; feelings about the baby's manifestations; and feelings about motherhood. The findings revealed the complexity of maternal feelings in the context of the NICU. However, the mothers' narcissistic investment in their babies, which led them to communicate with them using small gestures and sensory expressions, stood out in the maternal verbalizations, which simultaneously made it possible to build a symbolic place for the infant. (AU)

El presente estudio investigó la experiencia de maternidad de madres de bebés nacidos extremadamente prematuros durante sus hospitalizaciones en la UCI Neonatal. En particular, se buscó conocer los sentimientos maternos relacionados con este contexto. Participaron 18 madres cuyos bebés tenían entre 25 y 28 semanas de gestación y pesaban entre 625 g y 1000 g. Las madres fueron entrevistadas 15 días después del parto y las respuestas se examinaron mediante análisis de contenido cualitativo. Se desarrollaron tres ejes, derivados de las entrevistas: sentimientos sobre la UCI Neonatal; sentimientos sobre las manifestaciones del bebé; y sentimientos sobre la maternidad. Los hallazgos revelaron una complejidad de los sentimientos maternos en el contexto de la UCI Neonatal. Sin embargo, la inversión narcisista de las madres en sus bebés se evidenció en sus verbalizaciones, que las llevaba a comunicarse con ellos a través de pequeños gestos y expresiones sensoriales que, simultáneamente, permitían la construcción de un lugar simbólico para el bebé. (AU)

Gratitude intersects with affect as a boundary condition for daily satisfaction: An affective dynamics perspective.

This study is based on the affective events theory to investigate the situational predictors for gratitude-related differences in daily affect and satisfaction. We tested a moderated mediation model in which daily microevents (daily hassles and uplifts) were related to satisfaction through affect, at the within-person level. We also tested the cross-level interaction of gratitude on this indirect relationship. A total of 195 participants participated in a 5-day diary study (195 * 5 = 975 measurement occasions). Multilevel modeling showed that, at the person-level of analysis, daily microevents were significantly related to daily affect and, in turn, to daily satisfaction. At the daily level of analysis, trait-based gratitude moderated the mediation of daily positive affect on the relationship between daily uplifts and daily satisfaction, such that it become stronger for individuals who scored lower on gratitude, but gratitude did not moderate the relationship between daily hassles, negative affect, and satisfaction. These findings make relevant theoretical contributions to understanding the power of gratitude for daily affective dynamics. These results also expand knowledge on within-person processes that explain daily affect and satisfaction, in addition to more traditional between-person factors. In sum, the present research demonstrates that "being grateful" may be associated with being happy and that individuals who are less grateful need to experience more daily uplifts and positive affect to feel satisfied.

Compartilhar experiências ou prescrever orientações?: um estudo a partir de blogs sobre maternidade / Sharing experiences or prescribing guidelines?: a study from mom blogs / ¿Compartir experiencias o prescribir pautas?: un estudio de blogs sobre

Atualmente, muitas mães têm utilizado o ambiente digital, a exemplo dos blogs, como ferramenta de compartilhamento de experiências sobre a maternidade. No presente estudo, buscamos analisar as temáticas das postagens, bem como em que medida apresentam uma função prescritiva ou informativa, para além da função de compartilhamento de experiências. No caso das postagens com função prescritiva ou informativa, o presente estudo buscou também verificar o embasamento explícito dessas postagens. Foi realizada uma análise de frequência de 845 postagens dos 10 blogs brasileiros sobre maternidade mais acessados. As principais temáticas abordadas estão relacionadas a preocupações quanto ao desenvolvimento infantil, gestação e parto, práticas parentais e exigências da maternidade. Com exceção das postagens envolvendo a última temática, a maioria tinha função prescritiva ou informativa. Os resultados deste estudo confirmam que os conteúdos que circulam nesses blogs se apoiam em discursos construídos no campo da saúde, essencialmente prescritivos, sobre como agir como mãe

Currently, many mothers have used the digital environment, such as blogs, as a tool for sharing motherhood experiences. This study analyzed mom blogs posts' themes, as well as whether they are prescriptive or informative in addition to sharing experiences. We also verifi ed the explicit basis of the prescriptive and informative posts. A frequency analysis of 845 posts from the 10 most accessed Brazilian mom blogs was performed. The results showed that the most frequent themes are related to concerns about child development, pregnancy and childbirth, parenting practices and motherhood demands. Most mom blog posts analyzed had a prescriptive or informative function, except for the motherhood demands theme. Results confi rm that the content circulating in these blogs is based on the health sciences knowledge, which is essentially prescriptive on how to act as a mother

Actualmente, muchas madres han utilizado los blogs como herramienta para compartir experiencias de maternidad. Este estudio analizó los temas de las publicaciones de los blogs de mamás, así como si son prescriptivos o informativos además de compartir experiencias. También verificamos la base explícita de las publicaciones prescriptivas e informativas. Se realizó un análisis de frecuencia de 845 publicaciones de los 10 blogs de mamás brasileñas más visitados. Los temas más frecuentes están relacionados con las preocupaciones sobre el desarrollo infantil, el embarazo y el parto, las prácticas de crianza y las exigencias de la maternidad. La mayoría de las publicaciones analizadas tenían una función prescriptiva o informativa, a excepción del tema de las exigencias de la maternidad. Los resultados confirman que el contenido que circula en estos blogs se basa en el conocimiento de las ciencias de la salud, que es esencialmente prescriptivo sobre cómo actuar como madre

Telas na infância: postagens de especialistas em grupos de cuidadores no facebook / Screens in childhood: posts of specialists in caretakers' groups in the facebook / Pantallas en la infancia: las publicaciones de expertos en grupos de cuidadores en facebook

Apesar das crescentes investigações sobre uso de telas na infância, essa é uma temática complexa e ainda recente, que traz diversos desafios para pesquisadores e cuidadores. Comunidades virtuais em redes sociais são utilizadas por mães e pais para esclarecer dúvidas e receber conselhos acerca da parentalidade e saúde infantil, podendo, simultaneamente, assumir uma função prescritiva e normativa quanto ao seu modo de agir. Sendo assim, este artigo pretende compreender como o uso de telas na infância vem sendo abordado por especialistas em grupos de mães e pais no Facebook. Foi realizado um estudo qualitativo envolvendo 49 postagens de especialistas, sobretudo psicólogos e educadores, extraídas de cinco grupos públicos de mães e pais nessa rede social. Os textos das publicações foram verificados por meio de análise temática e discutidos com base no referencial teórico psicanalítico. Os resultados mostraram que os especialistas destacam os possíveis prejuízos do uso de telas na infância, além de fornecer orientações aos pais sobre como lidar com sua presença no cotidiano das crianças e de suas famílias. Concluiu-se que apesar dos grupos de cuidadores no Facebook serem uma ferramenta de divulgação de informações acerca do uso de telas na infância, cabe não naturalizar a presença de especialistas nesses espaços virtuais criados por pais e mães, interpondo-se nos saberes e nas trocas horizontalizadas entre os cuidadores.(AU)

Although investigations on the use of screens in childhood are increasing, this is a complex and recent topic, which poses several challenges for researchers and caregivers. Virtual communities in social networks are used by mothers and fathers to clarify doubts and receive advice regarding parenting and child health, at times, simultaneously, assuming a prescriptive and normative role on their way of acting. Therefore, this study aimed to understand how the use of screens in childhood has been approached by experts in groups of mothers and fathers on Facebook. A qualitative study was carried out involving 49 posts from specialists, mainly psychologists and educators, extracted from five public groups of mothers and fathers in this social network. The publications' texts were verified via thematic analysis and discussed based on the psychoanalytical theoretical framework. The results showed that experts highlight the possible damage of the use of screens in childhood, in addition to providing guidance to parents on how to deal with the presence of digital technology in the daily lives of children and families. It was concluded that, although caregivers' groups on Facebook are a tool for disseminating information about the use of screens in childhood, it is important not to naturalize the presence of specialists in these virtual spaces created by fathers and mothers, interposing in the horizontally interchanges that occur between the caregivers.(AU)

A pesar de las crecientes investigaciones sobre el uso de pantallas en la infancia, este es un tema complejo y aún reciente, que plantea varios desafíos para investigadores y cuidadores. Las comunidades virtuales en las redes sociales son utilizadas por madres y padres para aclarar dudas y recibir consejos sobre educación y salud infantil, pudiendo, al mismo tiempo, asumir un rol prescriptivo y normativo sobre su forma de actuar. Por lo tanto, este estudio tuvo como objetivo comprender cómo el uso de las pantallas en la infancia ha sido abordado por especialistas en grupos de madres y padres en Facebook. Se realizó un estudio cualitativo a partir de 49 publicaciones de especialistas, principalmente de psicólogos y educadores, extraídas de cinco grupos públicos de madres y padres en esta red social. Se realizó en los textos de las publicaciones un análisis temático y se utilizó el marco teórico psicoanalítico. Los resultados mostraron que los expertos destacan posibles daños que provoca el uso de pantallas en la infancia, además de orientar a los padres sobre cómo afrontar esta presencia de la tecnología digital en el día a día de los niños y sus familias. Se concluyó que, a pesar de que los grupos de cuidadores en Facebook son una herramienta de difusión de información sobre el uso de pantallas en la infancia, es importante no naturalizar la presencia de especialistas en estos espacios virtuales creados por padres y madres que se interpone entre los saberes e intercambios horizontales de los cuidadores.(AU)

Operative Pediatric Hand Trauma.

This study aims to describe the epidemiology of hand injuries in pediatric patients undergoing surgical treatment. A retrospective analysis of patients with traumatic hand injuries surgically treated over a 7-year period. A total of 155 patients were included. Fracture was the most common injury type (74.8%), most of which were open (54.3%). Incidence of articular fractures increased with age. The predominant mechanism of injury before age 10 was crush. In toddlers, only central digits were affected. Good functional results were achieved (Quick-DASH 1.37 ± 4.90). The incidence of hand injuries requiring surgery increased with age. The mechanism and segment affected varied with age groups. Although good functional results are expected, complications may occur 33% and secondary surgical procedures in 7.7%.

Coparentalidade aos 24 meses da criança: um estudo qualitativo / Coparentalidad a los 24 meses del niño: un estudio cualitativo / Co-Parenting with 24-Month-Old Children: A Qualitative Study

O objetivo deste estudo foi investigar a coparentalidade aos 24 meses da criança. Trata-se de pesquisa qualita-tiva, da qual participaram 10 famílias nucleares, com um único filho. A mãe e o pai responderam entrevista sobre sua experiência de maternidade e paternidade, res-pectivamente. Essas entrevistas foram examinadas por análise temática dedutiva, considerando os temas com-ponentes do modelo de coparentalidade de Feinberg: divisão de trabalho, acordo nos cuidados, apoio versusdepreciação coparental e gerenciamento das interações familiares. Os resultados revelaram que cuidados bási-cos e tarefas domésticas estavam sob responsabilidade predominantemente materna, enquanto o envolvimento paterno se dava sobretudo em atividades de lazer, tais como brincadeiras e passeios. Houve predomínio de relatos de satisfação quanto à divisão de trabalho. So-bre acordo nos cuidados, os participantes enfatizaram especialmente os desafios de negociar e estabelecer limites apropriados à criança aos 24 meses, visando à promoção das novas habilidades e da autorregulação infantil, bem como à prevenção de acidentes. Relatos de apoio e de depreciação coparental coexistiram nas famílias. Assim, evidenciou-se respeito de um genitor às contribuições do outro, admiração e manutenção da autoridade, embora também culpabilização, crítica e competição entre a mãe e o pai. Quanto ao gerencia-mento das interações familiares, houve predomínio de estratégias construtivas para resolução de confli-tos, com destaque às conversações entre os genitores. Discutem-se aspectos gratificantes e desafiadores da coparentalidade aos 24 meses da criança, com ênfase aos estressores normativos nessa etapa do desenvolvi-mento infantil e às potencialidades dos genitores para enfrentá-los colaborativamente.

El objetivo de este estudio fue investigar la coparentalidad a los 24 meses del niño. La investigación fue cualitativa y participaron 10 familias nucleares con un solo hijo. La madre y el padre respondieron una entrevista sobre su experiencia de maternidad y paternidad, respectivamente. Estas entrevistas fueron examinadas por análisis temático deductivo, considerando los te-mas componentes del modelo de coparentalidad de Feinberg: división del trabajo, acuerdo en el cuidado, apoyo vs.depreciación coparental y manejo de las interacciones familiares. Los resultados revelaron que los cuidados básicos y las tareas del hogar eran predo-minantemente responsabilidad materna, mientras que la participación paterna se producía principalmente en actividades de ocio como juegos y salidas. Hubo predominio de relatos de satisfacción con respecto a la división del trabajo. En cuanto a la concordancia en el cuidado, los participantes destacaron los desafíos de negociar y establecer límites adecuados para el niño a los 24 meses, con el objetivo de promover nuevas habilidades y la autorregulación del niño, así como la prevención de accidentes. Coexistieron relatos de apoyo y desvalorización. Así, se evidenció el respeto de uno de los padres por las contribuciones del otro, la admiración y el mantenimiento de la autoridad, aunque también reproches, críticas y competencia entre la madre y el padre. En el manejo de las interacciones familiares, hubo predominio de estrategias constructivas para la resolución de conflictos, con énfasis en conversaciones entre padres. Se discuten los aspectos gratificantes y desafiantes de la coparentalidad de una crianza a los 24 meses de edad, con énfasis en los factores estresantes normativos en esta etapa del desarrollo y el potencial de los padres para enfrentarlos en colaboración.

The current study aimed to investigate co-parenting in children of 24 months of age. It was a qualitative study in which the participants were 10 nuclear families, each with an only child. The mother and father attended an interview about their experience of maternity and pa-ternity, respectively. These interviews were examined using the deductive thematic analysis, considering the component themes of Feinberg's co-parenting model: division of labor, childrearing agreement, support versus undermining, and joint family management. The results revealed that essential childcare and household chores were predominantly under maternal responsibility, while paternal involvement was mainly in leisure activities such as play and strolls. Reports on satisfaction regard-ing the division of labor were predominant. Concerning the childrearing agreement, the participants particularly emphasized the challenges of negotiating and setting appropriate limits for the child at 24 months, aiming to promote new skills and self-regulation in the toddlers, as well as to prevent accidents. Reports of support and undermining coexisted in the families. Thus, respect of one parent for the contributions of the other, admiration and sustaining of authority, on the one hand, and blaming, criticism, and competition between mother and father, on the other, were evidenced. Regarding joint family management, there was a predominance of constructive strategies for conflict resolution with an emphasis on conversations between parents. Rewarding and chal-lenging aspects of co-parenting at 24 months of age are discussed, highlighting the normative stressors at this stage of child development and the potential of parents to cope with them cooperatively.

Thoracic Epithelioid Hemangioendothelioma: clinical demonstration and therapeutic procedures.

Epithelioid hemangioendotheliomais a low to intermediate grade malignant vascular tumors that can involve any organ. About 60-80%of patients are women, patient ages range 7 to 81 years, with a median age of 38 years. Four cases of thoracic epithelioid hemangioendotheliomas with different clinical presentation and disease progression are reported. Cases 1 and 2 are pulmonary epithelioid hemangioendotheliomas diagnosed at different advanced stages and patients died after 6 and 2,5 months of medical treatment, respectively. Case 3 corresponds to pleural epithelioid hemangioendothelioma, submit- ted to left lung decortication and pleuro-pericardial window; patient is free either from symptoms and radiographic manifestations for 10 months of follow-up. Case 4, of mediastinal epithelioid hemangioendothelioma, represented by a mass in the upper left mediastinum adherent to the aortic arch; patient underwent block excision of the mass followed by chemotherapy; subsequent recurrence 41 months later and the patient died 8 months after. The reported 4 cases reveal the heterogeneous clinical presentation of epithelioid hemangioendotheliomas with behavior in between benign and high-grade tumors, raising difficulty in either differentiating from other vascular tumors and previewing clinical outcome.

Adapting to a New Country During an Expatriate Mission: The Vital Role of Events and Emotions.

The aim of this study was to identify the most relevant positive and negative events, and their consequent emotional experiences, occurring during the adaptation to a new country in an expatriate mission. We opted to train an artificial neural network to explore the relation between events and emotions since there is increasing evidence of the nonlinear patterns characterizing the adaptation to a new country as well as regarding the superior performance of nonlinear methods for understanding the experience of emotions. We surveyed 99 expatriate workers who reported a total of 221 events and 2,467 associated emotions. Three judges categorized the events, reducing them into 11 categories. The neural network architecture grouped the events into 3 hidden layers, two of them leading to positive emotions and the other one leading exclusively to negative emotions. We found that events related to self-realization and recognition and to overall well-being were the most relevant to the experience of positive emotions while those related to security were the most important predictors of negative emotions. This study addresses a major gap in the expatriates' literature by relating specific occurrences with the phenomenological emotional experience. Practical implications are further discussed.

Gastroesophageal Reflux Disease Diagnosis by New Consensus in Clinical Practice: The Additional Value of Mean Basal Impedance.

BACKGROUND: Recently, Lyon consensus and ROME IV were published as there was a need to create a more objective evaluation for gastroesophageal reflux disease (GERD) in order to better predict treatment outcomes. However, with classical pH-impedance measures, some patients would still have diagnostic uncertainty, and new metrics, such as mean nocturnal basal impedance (MNBI), have emerged to corroborate with GERD diagnosis. The aim of the present study was to describe the prevalence of GERD, functional heartburn (FH), reflux hypersensitivity (RH), and undetermined diagnosis using current consensuses and to evaluate if MNBI could be considered a supportive measure for the diagnosis of GERD. METHODS: Patients who underwent pH-multichannel intraluminal impedance (MII-pH) for suspected GERD between 2013 and 2018 were included. Subjects with previous diagnosis of GERD (e.g., esophagitis grade C or D according to Los Angeles classification, Barrett's esophagus, or peptic stricture), atypical symptoms, major esophageal motor disorder, eosinophilic esophagitis, or under proton pump inhibitor were excluded from the analysis. RESULTS: We included 75 patients. The prevalence of GERD, FH, RH and undetermined diagnosis was 44%, 14.7%, 12%, and 29.3%, respectively. MNBI was lower in patients with GERD (GERD: 1,307.5 ± 817.9 Ω vs. FH: 3,039.6 ± 1,040.8 Ω, RH: 2,617.1 ± 1,342.2 Ω, undetermined: 2,351.9 ± 1,018.2, p < 0.001), although it was similar between patients with FH and RH (p = 0.44) or between undetermined diagnosis and FH/RH (p = 0.15). More patients with a GERD diagnosis had a MNBI under 2,292 Ω (GERD: 93.9% vs. non-GERD: 31.7%, p < 0.001). CONCLUSION: In our study, using MII-pH criteria, less than half of the patients had a GERD diagnosis. MNBI showed additional value as another metric for the diagnosis of GERD.

Gynecological history to diagnosis and pregnancy outcomes in diagnosed Wilson's disease patients under therapy - A bicentric matched-control cohort study.

INTRODUCTION: most studies narrowly focus on pregnancy outcome comparisons between Wilson's disease (WD) patients on and off treatment. We aimed to identify menses irregularities in untreated WD, and to evaluate pregnancy outcomes in treated WD patients as compared to matched controls (with and without liver disease). METHODS: females with WD, hepatitis C (liver disease controls), and other gastrointestinal conditions (controls without liver disease) were identified at two tertiary hospital gastroenterology departments. Gynecological and obstetric data were retrospectively collected. A comparison of gynecological and obstetric outcomes was performed between the groups, and regression models were used to further assess obstetric outcomes. RESULTS: a total of 18 females with WD were identified, comprising 19 pregnancies under treatment in 11 patients, and 20 females were included in each control group. Age and liver disease stage were adjusted between groups. The incidence of menses irregularities was higher for WD (late menarche, 83 % vs. 10 % vs. 10 %, p < 0.01; irregular cycles, 100 % vs. 20 % vs. 20 %, p < 0.01; amenorrhea, 67 % vs. 10 % vs. 5 %, p < 0.01). Logistic regression models identified WD as a predictor of miscarriage and low birth weight (OR: 6.0; CI: 1.1-33.3; p < 0.05) but not of birth defects. Neither therapies (D-penicillamine 300 mg or zinc acetate 150 mg) nor disease presentation (hepatic and/or neurological) were associated with obstetric complications in WD subjects. CONCLUSION: there was a higher incidence of menses irregularities in untreated females with WD. In addition, our data suggest that treated WD still carries a higher risk of spontaneous abortion and low birth weight when compared to matched control groups with and without liver disease.