A proof-of-concept study testing the factor structure of the Stop Signal Task: overlap with substance use and mental health symptoms.

Background: Research utilizing experimental tasks usually does not report estimates of internal reliability of measurement. However, modern measurement theories conceptualize reliability as sample dependent indicating that reliability should be empirically demonstrated in the samples used to make inferences.Objectives: Test whether confirmatory factor analytic (CFA) estimates of reliability can be applied to a commonly used task measuring response inhibition (the Stop Signal Task) to predict substance use (alcohol and cannabis) and mental health symptoms.Methods: Thirty-seven participants between the ages of 18-20 (72% female; 16% Asian, 3% Native American, 11% Black or African American, 59% White; 32% Latino/a/x) were recruited via social media advertisement and attended a laboratory visit. The Stop Signal Reaction Time (SSRT) was calculated as the outcome for three experimental blocks and used as indicators in a CFA.Results: CFA suggests the task yields reliable scores; factor loadings were statistically significant (p < .05) and substantial (standardized loadings ranged from .74 to .94). However, reliability increased across experimental blocks and error was non-trivial (ranging from 50% to 12% of the variance). The inhibition factor predicted higher maximum number of drinks consumed (ß = .37, p < .05), higher frequency of cannabis use (ß = .39, p < .05), and more cannabis use occasions within using days (ß = .40, p < .05), as well as facets of mental health (anxious/depression, attention, and anxiety problems; all p's < .05).Conclusion: Results support the utility of CFA to test for reliability of measurement, with the ability to inhibit dominant responses serving as a transdiagnostic correlate of substance use and mental health problems.

Intersection of minority health, health disparities, and social determinants of health with psychopharmacology and substance use.

These articles provide a window into the breadth of issues at the intersection of MHDS with psychopharmacology and substance use. Integrating the fields of psychopharmacology and basic behavioral addictions science with research on MHDS is not only of public health importance, but can help further elucidate our understanding of human behavior in all of its complexity. As demonstrated here, a better understanding of the synergy between societal context(s) and individual-level processes can lead to interventions tailored to specific risk and resilience factors; interventions that are personalized and contextualized have the potential to improve the health of our society. We are very grateful to the authors for their contributions to this special issue. We hope that professionals from various disciplines who read this special issue become inspired to bridge psychopharmacological and social determinants perspectives in their own work, and, in turn, accelerate scientific progress within each field. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The cultural equivalence of measurement in substance use research.

Across a wide range of substance use outcomes, ethnic/racial minorities in the U.S. experience a disproportionately higher burden of negative health outcomes and/or lower levels of access to care (relative to non-Latinx White individuals). Various explanations for these substance use-related health disparities have been proposed. This narrative review will not focus on the theoretical content of these explanations but will instead focus on the underlying statistical frameworks that are used to test such theories. Here, we provide a narrative review of psychometric critiques of cross-cultural research, which collectively suggest that (a) research testing similarities and differences among ethnic/racial groups often miss or omit to test statistical assumptions of equal instrument functioning across the ethnic/racial groups being compared; (b) testing the assumptions of equal instrument functioning is feasible using established guidelines from modern measurement theories; and (c) substance use research may need to explicitly incorporate the tests of equal instrument functioning to prevent bias when making inferences across ethnic/racial groups. We provide recommendations for evaluating the cultural equivalence of measurement using structural equation modeling, and advocate that cross-cultural substance use research move toward statistical approaches that are better positioned to test for (and model) bias in measurement. Explicitly testing the cultural equivalence of measurement when making inferences across cultural groups (within a falsifiable psychometric framework) can advance our understanding of similarities and differences among ethnic/racial groups, and hence can provide a more socially just (and statistically robust) scientific base. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Social determinants of alcohol and cigarette use by race/ethnicity: Can we ignore measurement issues?

Psychometric critiques of cross-cultural research emphasize testing whether instruments measure the same construct across cultural groups. We tested for measurement invariance (by race/ethnicity) of instruments used to evaluate the relationship between alcohol and tobacco use with perceived discrimination and socioeconomic status (SES). Tests of psychometric equivalence across race/ethnicity focused on: the latent organization of constructs (configural invariance); if observed indicators have equal factor loadings or "true score" variance (metric invariance); and whether manifest indicators change uniformly contingent on change in the latent variable (scalar invariance). A cross-sectional survey of 2,376 cigarette smokers (794 Black, 786 Latinx, 796 White; mean age = 43 [SD = 12]; 58% female) was recruited via an online research panel. Discrimination was indicated by self-report; SES was indicated by self-reported education, employment, income, and the "SES Ladder;" alcohol use was indicated by frequency and typical quantity of drinking, and frequency of heavy drinking; tobacco use was indicated by frequency of smoking, cigarettes per smoking day, and time to first cigarette. All instruments demonstrated configural invariance; either full metric invariance (alcohol and discrimination) or partial metric invariance (tobacco and SES); and all constructs demonstrated partial scalar invariance. Results support psychometric critiques; for example, all of the SES indicators violated assumptions of classical measurement theory for valid between group comparisons. All of our instruments displayed some degree of systematic bias in measurement across race/ethnicity. Studies testing ethnic/racial differences may need to move beyond classical measurement theory, and may benefit from using statistical approaches that can test for (and model) bias in measurement. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Dysregulation as a correlate of cannabis use and problem use.

OBJECTIVE: Cannabis users with a dysregulatory risk factor may be particularly vulnerable to engaging in more frequent and problematic cannabis use. Contemporary models of dysregulated behavior suggest that dysregulation emerges due to distinct mechanisms. The current study seeks to examine the dysregulatory correlates of cannabis involvement, including working memory capacity, delay discounting, impulsivity, and reward sensitivity. METHOD: Participants were 104 non-treatment seeking frequent cannabis users (the average participant used cannabis 71% of the days/past 60 days [SD = 22%], with an average of two uses per day [SD = 1.2]). Mean age was 21.3 (SD = 4.3); 36.5% were female. Working memory was assessed via the Trail-Making Test-B and the Digit Span subtests of the WAIS-III, delay discounting was assessed via a computer-based task, trait impulsivity was self-reported via the Barratt Impulsiveness Scale, and reward sensitivity was self-reported via the Reward Dependence Scale and the Snaith-Hamilton Pleasure Scale. RESULTS: Structural equation modeling estimated the associations between different facets of dysregulation and cannabis involvement. Results suggest that poor working memory capacity and high trait impulsivity were associated with both use and problem use. Greater delay discounting was associated with problem use, but not with frequency of use. Low reward sensitivity was associated with more frequent cannabis use, but not with problem use. CONCLUSIONS: Results confirm that the dysregulatory correlates of cannabis involvement consist of multiple dimensions of functioning. Prospective studies that assess the multidimensional structure of dysregulation and cannabis involvement are needed in order to disaggregate the dysregulatory antecedents and consequences of cannabis involvement.

Parental drinking as context for parental socialization of adolescent alcohol use.

INTRODUCTION: While alcohol-specific parenting practices have demonstrated unique effects on adolescent substance use, their efficacy in the context of parental drinking levels has not been studied. This study assessed the influence of three alcohol-specific parenting practices (rules, punishment, communication) on adolescent alcohol use, and the degree to which those associations varied by parents' own drinking. METHODS: We conducted logistic regression analyses among US adolescents (N = 1023; 52% female; 12% Hispanic; 76% Caucasian, 5% Black, 8% mixed race, 11% other race/ethnicity; mean age at enrollment = 12.2 years) to examine the relationship between alcohol-specific parenting practices and the odds of ever having experienced two drinking milestones, having a full drink of alcohol and a heavy drinking episode, and whether parental drinking levels moderated those associations. RESULTS: Strict rules for drinking, higher levels of cautionary communication messages, and punishment for drinking were associated with lower odds of alcohol use. Witnessing parent drinking increased the risk for both alcohol outcomes. Furthermore, parental drinking modified the influence of parental cautionary messages on alcohol use such that the effect was particularly salient for those youth who witnessed and whose parents reported higher levels of alcohol use. CONCLUSIONS: Family-based preventive interventions should include skills training in alcohol-specific parenting practices with emphasis on reducing parental alcohol use particularly when children are present.

Testing variability in response to a brief alcohol intervention: The role of self-regulation and the therapeutic relationship.

The current study tests individual differences in response to a mandated brief motivational intervention (BMI) for college student drinking. Participants consisted of 99 (45% female) students who were referred for violating campus alcohol policy. Within-subject analyses suggest that the BMI led to a significant reduction in frequency of drinking and alcohol-related problems at the 1-month follow-up, with a nonsignificant trend in reduction of quantity of drinking and no difference in maximum level of drinking. However, there was a statistically significant amount of variability in response to the BMI across frequency, quantity, maximum, and alcohol-related problems. Individual differences in self-regulation and the strength of the therapeutic relationship were used to predict variability in change associated with participating in the intervention. Lower levels of self-regulation predicted more alcohol-related problems at 1 month following the BMI. A stronger therapeutic relationship predicted lower frequency, quantity, and maximum level of drinking at 1 month following the BMI. At the 12-month follow-up, there was a significant decay in the efficacy of the intervention, with a statistically significant amount of variability across all outcomes. Lower self-regulation was associated with more problems at 12 months. Individual differences in the therapeutic relationship were not associated with decay of efficacy between 1 and 12 months across any of the outcome variables. Results are consistent with both etiological heterogeneity and common factors models of the efficacy of psychotherapy, and extend these models to explaining outcomes of brief alcohol interventions in students mandated to treatment. (PsycINFO Database Record

Social and Individual-Level Predictors of Alcohol Use Initiation and Escalation: Replicating and Extending Tests of Differential Effects.

OBJECTIVE: Although alcohol use is considered a developmental phenomenon, there is a relative dearth of studies disaggregating predictors of alcohol use initiation versus early escalation of drinking. One perspective that has emerged is that social levels of influence may be relevant for the initiation of drinking, whereas individual levels of influence may be relevant for the early escalation in level of drinking among initiators, which we refer to as the specificity hypothesis. METHOD: A sample of alcohol-naive youth (n = 944; mean age = 12.16 years, SD = 0.96) was prospectively assessed for 3 years, spanning six waves of data collection. RESULTS: Both social (parental conflict, perceived prevalence of peer drinking) and individual-level (higher sensation seeking) variables uniquely predicted increases in the likelihood of alcohol initiation. Likewise, both social (perceived descriptive norms of peer drinking) and individual-level (lower school grades, higher sensation seeking) variables uniquely predicted escalation in level of drinking among initiators (although only marginally for sensation seeking). CONCLUSIONS: Overall, there was little support for the specificity hypothesis. Our findings suggest that to assume that social and individual-level processes differentially predict drinking outcomes may be a false dichotomy. Theoretical work may benefit from drawing from developmental models emphasizing the interplay between individual and environmental factors in the prediction of the early development of drinking. The emergence of drinking behaviors is likely to result from a developmental cascade of interacting variables that make the ontogeny of drinking unlikely to emerge from a single class of variables.

Cognitive appraisals of alcohol use in early adolescence: Psychosocial predictors and reciprocal associations with alcohol use.

Early adolescence is a dynamic period for the development of alcohol appraisals (expected outcomes of drinking and subjective evaluations of expected outcomes), yet the literature provides a limited understanding of psychosocial factors that shape these appraisals during this period. This study took a comprehensive view of alcohol appraisals and considered positive and negative alcohol outcome expectancies, as well as subjective evaluations of expected outcomes. Developmental-ecological theory guided examination of individual, peer, family, and neighborhood predictors of cognitive appraisals of alcohol and use. A community sample of 378 adolescents (mean age 11.5 years at Wave 1, 52% female) was assessed annually for 4 years. Longitudinal path analysis suggested that the most robust predictors of alcohol appraisals were peer norms. Furthermore, perceived likelihood of positive and negative alcohol outcomes prospectively predicted increases in drinking. There was limited support for appraisals operating as mediators of psychosocial risk and protective factors.

Hypothetical evaluations of positive and negative alcohol consequences in adolescents across various levels of drinking experience.

Research supports the importance of the subjective evaluation of alcohol-related consequences, and theory suggests that these evaluations may depend on one's prior experience. The goal of the present study was to understand how adolescents subjectively evaluate the potential negative and positive consequences of drinking and to test the hypothesis that evaluations differ as a function of personal experience with alcohol use and consequences. Participants were 697 adolescents (55% female) who completed online surveys assessing lifetime drinking experience and hypothetical evaluations of 13 negative and 9 positive consequences. Never having consumed a full drink of alcohol (vs. having consumed a full drink, but not having negative consequences) was significantly associated with higher mean negative evaluations and lower mean positive evaluations. Those who had a full drink (vs. those who had not) rated close to half of the negative consequence items as significantly less bothersome, and all of the positive consequences as significantly more enjoyable. However, there was little evidence in this sample that evaluations differ between drinkers with and without experience with negative consequences. Overall, findings suggest that youth who have experience with simply consuming alcohol may place more value on the positive and less value on some of the negative consequences of drinking, which has the potential to impact decisions to continue to drink. Longitudinal research uncovering the direction of evaluation-experience effects and mechanisms other than consequence experience, are essential next steps. (PsycINFO Database Record

Developmental trends in alcohol use initiation and escalation from early to middle adolescence: Prediction by urgency and trait affect.

Studies on adolescent drinking have not always been able to distinguish between initiation and escalation of drinking, because many studies include samples in which initiation has already occurred; hence, initiation and escalation are often confounded. The present study draws from a dual-process theoretical framework to investigate: if changes in the likelihood of drinking initiation and escalation are predicted by a tendency toward rash action when experiencing positive and negative emotions (positive and negative urgency) and whether trait positive and negative affect moderate such effects. Alcohol naïve adolescents (n = 944; age M = 12.16, SD = .96; 52% female) completed 6 semiannual assessments of trait urgency and affect (Wave 1) and alcohol use (Waves 2-6). A 2-part random-effects model was used to estimate changes in the likelihood of any alcohol use versus escalation in the volume of use among initiators. Main effects suggest a significant association between positive affect and change in level of alcohol use among initiators, such that lower positive affect predicted increased alcohol involvement. This main effect was qualified by a significant interaction between positive urgency and positive affect predicting changes in the escalation of drinking, such that the effect of positive urgency was augmented for those high on trait positive affect, though only at extremely high levels of positive affect. Results suggest risk factors in the development of drinking depend on whether initiation or escalation is investigated. A more nuanced understanding of the early developmental phases of alcohol involvement can inform prevention and intervention efforts. (PsycINFO Database Record

Testing a "content meets process" model of depression vulnerability and rumination: Exploring the moderating role of set-shifting deficits.

BACKGROUND AND OBJECTIVES: MacCoon and Newman's (2006) "content meets process" model posits that deficits in cognitive control make it difficult to disengage from negative cognitions caused by a negative cognitive style (NCS). The present study examined if the interactive effect of cognitive set-shifting abilities and NCS predicts rumination and past history of depression. METHODS: Participants were 90 previously depressed individuals and 95 never depressed individuals. We administered three laboratory tasks that assess set-shifting: the Wisconsin Card-Sorting Task, the Emotional Card-Sorting Task, and the Internal Switch Task, and self-report measures of NCS and rumination. RESULTS: Shifting ability in the context of emotional distractors moderated the association between NCS and depressive rumination. Although previously depressed individuals had more NCS and higher trait rumination relative to never depressed individuals, shifting ability did not moderate the association between NCS and depression history. LIMITATIONS: The cross-sectional correlational design cannot address the causal direction of effects. It is also not clear whether findings will generalize beyond college students. CONCLUSIONS: NCS was elevated in previously depressed individuals consistent with its theoretical role as trait vulnerability to the disorder. Furthermore, NCS may be particularly likely to trigger rumination among individuals with poor capacity for cognitive control in the context of emotional distraction.

An examination of the specificity of motivation and executive functioning in ADHD symptom-clusters in adolescence.

OBJECTIVE: Motivation and executive functioning are central to the etiology of attention-deficit/hyperactivity disorder (ADHD). Furthermore, it has been hypothesized that motivation should show specificity of association with ADHD-impulsivity/hyperactivity symptoms, whereas executive functioning should show specificity of association with ADHD-inattention symptoms. This study tests this specificity-hypothesis and extends previous research by conceptualizing motivation to include both reactivity to reward and punishment. METHODS: Executive functioning was assessed using two different laboratory measures (the Wisconsin-Card-Sort and Stop-Signal Tasks) and motivation was measured using a laboratory measure of sensitivity to reward and punishment (the Point-Scoring-Reaction-Time Task). RESULTS: Findings suggested specificity of association between executive functioning and symptoms of inattention, and between motivation and symptoms of impulsivity/hyperactivity. However, support varied across indices of executive functioning. CONCLUSIONS: Results provide support for multiple component models of ADHD symptoms and extend the literature by providing a theoretically based conceptualization of motivation grounded on developmental neuroscience models of motivated behavior.

Executive functioning moderates the relationship between motivation and adolescent depressive symptoms.

We investigated the association between adolescent depressive symptoms and components of executive functioning (EF), including planning (Tower of London), set-shifting (Wisconsin Card Sorting Task), and inhibition (Stop Signal Task) in a community sample of 12-14 year olds. Further, EF was tested as a moderator of motivation (as operationalized by revised Reinforcement Sensitivity Theory) effects on depressive symptoms. Results suggested that planning ability was associated with depressive symptoms. Furthermore, planning ability moderated the relationship between motivation (fight-flight- freeze system; FFFS) and depressive symptoms, such that among adolescents with poor planning ability the FFFS positively predicted depressive symptoms, but among adolescents with strong planning ability the FFFS negatively predicts depressive symptoms. Neither set-shifting nor inhibition was associated with depressive symptoms. Findings highlight the need to consider multiple components of EF and to integrate motivational and executive dysfunction models to the study of depression.

Reinforcement sensitivity theory and alcohol outcome expectancies in early adolescence.

BACKGROUND: Little research has examined the development of alcohol expectancies in childhood, a notable omission as expectancies are viable targets for prevention programs. Moreover, limited alcohol expectancies research has been conducted from the perspective of psychobiological models of motivation despite the strong conceptual links between such models and cognitive models of alcohol use. OBJECTIVE: To examine if the associations between individual differences from the revised reinforcement sensitivity theory (Gray JA, McNaughton N. The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System (2nd ed.). Oxford, UK: Oxford University Press, 2000) and alcohol use is mediated by alcohol expectancies in a large community sample of early adolescents using a prospective design. METHODS: 378 families (1 caregiver; 1 child) were recruited via random digit phone call using a prospective design. RESULTS: Our findings suggest that both a strong behavioral approach system and fight-flight or freeze system were associated with high levels of positive outcome expectancies, which subsequently predicted an increase in likelihood of alcohol use. There was also some evidence that drive (an aspect of behavioral approach system) was also positively associated with negative expectancies, which subsequently predicted a low probability of alcohol use. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Individual differences in reinforcement sensitivity may influence the acquisition of positive and negative outcome expectancies, thereby potentially influencing the likelihood of alcohol use in early adolescence. Thus, reinforcement sensitivity theory is a promising theory to account for the link between neural models of addiction and early acquisition of alcohol use in humans.

Implicit cognition and substance use: the role of controlled and automatic processes in children.

OBJECTIVE: Most cognitive models of substance abuse and dependence posit that controlled and automatic processes are central to substance use. Tests of these models rely on methods that are interpreted to measure one or the other of these processes. There has been growing interest in the use of implicit substance use tasks, which are posited to reflect automatic processes. Recent model advancements suggest that behavior is determined by multiple cognitive processes and that dual-process models may provide an overly simplistic account of the cognitive process involved in the assessment of implicit cognition. The goal of the current study was to apply the Quad Model to children's performance on implicit substance use tasks and consider associations with early substance use. METHOD: Children (N = 378; 52% girls) ranging from 10 to 12 years old completed alcohol and cigarette Single Category Implicit Association Tests (SC-IATs) and self-reports of substance use. RESULTS: Four distinct cognitive processes were found to influence SC-IAT performance, one of which reflected automatic activation, the process typically viewed as central to IAT performance. Differences across drinking status revealed weaker automatic activation of negative alcohol associations for those who had (vs. had not) initiated drinking, and a strong likelihood to overcome biased attitudes was supported for all children. The low prevalence of cigarette use in our young sample prohibited examination of the model across smoking status. CONCLUSIONS: Findings suggest that performance on implicit substance use tasks is not process pure. Quantifying and interpreting the multiple influencing processes are crucial for further development and evaluation of cognitive risk models of substance use.