Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review.

Cardiovascular diseases remain the main cause of death worldwide which makes it essential to better understand, diagnose, and treat atherosclerosis. Artificial intelligence (AI) and novel technological solutions offer us new possibilities and enable the practice of individually tailored medicine. The study was performed using the PRISMA protocol. As of January 10, 2023, the analysis has been based on a review of 457 identified articles in PubMed and MEDLINE databases. The search covered reviews, original articles, meta-analyses, comments, and editorials published in the years 2009-2023. In total, 123 articles met inclusion criteria. The results were divided into the subsections presented in the review (genome-wide association studies, radiomics, and other studies). This paper presents actual knowledge concerning atherosclerosis, in silico, and big data analyses in cardiology that affect the way medicine is practiced in order to create an individual approach and adjust the therapy of atherosclerosis.

Harmful female footwear: A public health perspective.

Footwear fashion is an instance of a socially formed attitude affecting somatic population health. High-heeled, particularly pointy-toed shoes are posed to structurally distort and overload feet leading to musculoskeletal sequelae. Here we compiled multilanguage website images presenting female footwear produced by the top manufacturers to assess the advertising effects on the prevailing height of heels worn by women. The method was based on the analysis of websites using the command "woman shoes" in scores of languages of the Internet Google browser. We then compared the results of the internet search with those of a live street surveillance of the footwear worn by 100 adult women in the downtown Warsaw metropolis in Poland. We found that stiletto heels with pointed shoe tips significantly predominated in images representing the countries belonging to the Western cultural sphere compared to less affluent world areas where low or flat heels prevailed. However, we noted a gradual departure from the fashion of high heels over the last decade, confirmed by live street surveillance, liable to reflect changes in the website presentations of top shoe manufacturers consistent with increasing awareness of potential harm by high heels. Yet the female aptitude for wearing more physiologic shoe models appears to exceed that resulting from marketing campaigns. Doing away with high-heeled pointy-toed shoes requires intensification of pro-health preventive measures in the field of public health.

Symmetry and asymmetry in atherosclerosis.

Atherosclerosis remains the main cause of death worldwide. Most important issues concerning atherosclerosis are hemodynamics and how it affects plaque prevalence and distribution, as well as the symmetry and asymmetry of vasculature and plaques. To present the symmetry in the vascular system an analysis of PubMed and MEDLINE databases was performed. As of February 21, 2023, the results were as follows: for "symmetry" AND "atherosclerosis" there were 47 results; for "symmetry" AND "atherosclerotic lesions" - 20 results; for "symmetry" AND "artery stenosis" - 82 results; for "asymmetry" AND "atherosclerosis" - 87 results. Not without meaning are preventive measures. In the light of the Fourth Industrial Revolution artificial intelligence (AI) solutions help to develop new tools outperforming already existing cardiovascular risk scales. The aim of this paper is to present a current view on symmetry within vasculature and atherosclerosis as well as present a new approach to assess individuals' cardiovascular risk in accordance with precision medicine assumptions. Symmetry and asymmetry within the human vascular system play a crucial role in understanding of arterial diseases, including atherosclerosis. Moreover, it is unavoidable to use AI in cardiovascular risk stratification. Int J Occup Med Environ Health. 2023;36(6):693-703.

Ventilatory function and oxygen delivery at high altitude in the Himalayas.

This study aimed to evaluate changes in lung function assessed by spirometry and blood gas content in healthy high-altitude sojourners during a trek in the Himalayas. A group of 19 Italian adults (11 males and 8 females, mean age 43 ± 15 years, and BMI 24.2 ± 3.7 kg/m2) were evaluated as part of a Mount Everest expedition in Nepal. Spirometry and arterial blood gas content were evaluated at baseline in Kathmandu (≈1400 m), at the Pyramid Laboratory - Observatory (peak altitude of ≈5000 m), and on return to Kathmandu 2-3 days after arrival at each site. All participants took 250 mg of acetazolamide per os once daily during the ascent. We found that arterial hemoglobin saturation, O2 and CO2 partial pressures, and the bicarbonate level all decreased (in all cases, p < 0.001 with R2 =0.70-0.90), while pHa was maintained stable at the peak altitude. Forced vital capacity (FVC) remained stable, while forced expiratory volume in 1 s (FEV1) decreased (p = 0.010, n2p =0.228), resulting in a lower FEV1/FVC ratio (p < 0.001, n2p =0.380). The best predictor for acute mountain sickness was the O2 partial pressure at the peak altitude (p = 0.004, R2 =0.39). Finger pulse oximetry overestimated peripheral saturation relative to arterial saturation. We conclude that high-altitude hypoxia alters the respiratory function and the oxygen saturation of the arterial blood hemoglobin. Additionally, air rarefaction and temperature reduction, favoring hypoxic bronchoconstriction, could affect respiration. Pulse oximetry seems not enough to assist medical decisions at high altitudes.

Surgical safety checklist: an element of work organization in the operating theater / Lista de verificação de segurança cirúrgica: um elemento de organização do trabalho no bloco cirúrgico

Objectives: the surgical safety checklist (SSC) is a document that is intended to increase patient safety in the operating theater by eliminating avoidable errors. The original document has been published in English by the WHO which recommends its obligatory use. The document's name is often distorted when translated into European languages, for instance into the "surgical control list". This article aims to assess the consequences of the distortion of the originally intended meaning for the completion of SSC in the operating theater. Methods: we compared the exactness of the meaning of translation in 29 European languages based on Google translator. Particular attention was paid to the presence of essential words such as "checklist" and "safety" in the translation. Results: we found that in 15 out of the 29 languages, the translation of these two words was incorrect, particularly in Slavic languages. The most often mistranslation was the "control card" or "control list", which was a misnomer. Conclusions: the translation of the SSC name into native languages is inadequate in about one-half of the cases, which may jeopardize its proper use by team members of the operating theater, and thus the patient perioperative safety.

Objetivo: a lista de verificação de segurança cirúrgica (SSC) é um documento que visa aumentar a segurança do paciente no centro cirúrgico, eliminando possíveis erros. O documento original foi publicado em inglês pela OMS que recomenda seu uso obrigatório. O nome do documento é frequentemente distorcido quando traduzido para idiomas europeus, por exemplo, na "lista de controle cirúrgico". Este artigo visa avaliar as consequências da distorção do significado originalmente pretendido para a realização do SSC na sala de cirurgia. Métodos: para isso, comparamos a exatidão do significado da tradução em 29 idiomas europeus com base no tradutor do Google. Atenção especial foi dada para a presença de palavras essenciais como "lista de verificação" e "segurança" na tradução. Resultados: descobrimos que em 15 dos 29 idiomas, a tradução dessas duas palavras estava incorreta, principalmente em idiomas eslavos. A tradução incorreta mais frequente era o "cartão de controle" ou "lista de controle", o que era um equívoco. Conclusão: a tradução do nome do SSC para as línguas nativas é inadequada em cerca de metade dos casos, o que pode comprometer seu uso adequado pelos membros da equipe de centro cirúrgico e, portanto, a segurança perioperatória do paciente.

Medical Records: A Historical Narrative.

The history of medical records is thousand-year-long, with earlier roots in ancient civilizations. Until the 19th century, medical records mainly served educational purposes, later assuming other roles such as in insurance or legal procedures. This article comprehensively describes and reviews the development of medical records from ancient to modern times in Europe and North America, reflecting alterations and adaptations compliant with the mental and technological capabilities of a given period. We searched PubMed and Google Scholar databases to collect pertinent articles. English articles or those having English abstracts were considered. The search terms included "Medical Records," "Health Records," "History of Medicine," and "eHealth" and covered the last hundred years. References were also picked out from the identified articles. Overall, 600 articles were identified, 158 of which were judged thematically relevant. The general conclusion is that medical records undergo a revolutionary change from paper-based to electronic format, which reflects the development of eHealth systems. The migration process to eHealth records involves the use of artificial intelligence (AI) algorithms that streamline medical services by using faster and simpler working methods. AI benefits both patients and providers as it improves patient management and communication among medical centers, spares resources, identifies contamination or infections, and limits health costs. These advantages have become pointedly apparent during the recent COVID-19 scourge.

In Silico Finite Element Modeling of Stress Distribution in Osteosynthesis after Pertrochanteric Fractures.

A stabilization method of pertrochanteric femur fractures is a contentious issue. Here, we assess the feasibility of rapid in silico 2D finite element modeling (FEM) to predict the distribution of stresses arising during the two most often used stabilization methods: gamma nail fixation (GNF) and dynamic hip screw (DHS). The modeling was based on standard pre-surgery radiographs of hip joints of 15 patients with pertrochanteric fractures of type A1, A2, and A3 according to the AO/OTA classification. The FEM showed that the stresses were similar for both GNF and DHS, with the medians ranging between 53-60 MPa and consistently lower for A1 than A3 fractures. Stresses also appeared in the fixation materials being about two-fold higher for GNF. Given similar bone stresses caused by both GNF and DHS but shorter surgery time, less extensive dissection, and faster patient mobilization, we submit that the GNF stabilization appears to be the most optimal system for pertrochanteric fractures. In silico FEM appears a viable perioperative method that helps predict the distribution of compressive stresses after osteosynthesis of pertrochanteric fractures. The promptness of modeling fits well into the rigid time framework of hip fracture surgery and may help optimize the fixation procedure for the best outcome. The study extends the use of FEM in complex orthopedic management. However, further datasets are required to firmly position the FEM in the treatment of pertrochanteric fractures.

Artificial Intelligence and Precision Medicine: A Perspective.

This article aims to present how the advanced solutions of artificial intelligence and precision medicine work together to refine medical management. Multi-omics seems the most suitable approach for biological analysis of data on precision medicine and artificial intelligence. We searched PubMed and Google Scholar databases to collect pertinent articles appearing up to 5 March 2021. Genetics, oncology, radiology, and the recent coronavirus disease (COVID-19) pandemic were chosen as representative fields addressing the cross-compliance of artificial intelligence (AI) and precision medicine based on the highest number of articles, topicality, and interconnectedness of the issue. Overall, we identified and perused 1572 articles. AI is a breakthrough that takes part in shaping the Fourth Industrial Revolution in medicine and health care, changing the long-time accepted diagnostic and treatment regimens and approaches. AI-based link prediction models may be outstandingly helpful in the literature search for drug repurposing or finding new therapeutical modalities in rapidly erupting wide-scale diseases such as the recent COVID-19.

Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge.

Pedobarography is a modern technology enabling the assessment of the locomotor system based on the plantar pressure distribution. The technic is useful in the rehabilitation of various types of dysfunction of body movement. This chapter aims to describe the application of pedobarography in clinical therapy. The qualitative analysis is based on a review of articles in English, French, German, Polish, Portuguese, Spanish, Turkish, and Chinese in Medline/PubMed, Cochrane Library, Embase, and PEDro databases. The search covered the articles on clinical trials, randomized controlled trials, meta-analyses, and reviews published over 1984-2020. The literature shows that pedobarography is a safe non-invasive method that is useful for the examination of foot biomechanics with a reference to the entire musculoskeletal system. A pedobarographic examination enables insight into a motion disorder, its plausible relation to a systemic pathology, and monitoring the course of treatment and rehabilitation.

Compliance with the Surgery Safety Checklist: An Update on the Status.

WHO has recommended the implementation of the Surgery Safety Checklist (SSC) to reign in often simple logistic errors that lead to numerous complications, some of them being fatal, in the perioperative period. This study aims to discuss doubts presented in the medical literature concerning the effectiveness of SSC in the currently existing form. The article is based on the literature search performed in PubMed using the command phrase "Surgery Safety Checklist". The search yielded 1,476 articles up to March 2021. Out of this group, we selected 811 articles for further detailed analysis. The selection was based on the meritorious SSC-related topicality and scrutinized content of the articles. Out of these articles, we identified 59 studies that specifically raised the issue of the effectiveness of SSC use in its current form, which we discussed herein in detail. The review distinctly indicates that the SSC reduces perioperative complications including fatalities. However, there are issues reported with the itemized content of the checklist that hardly correspond to the diverseness of patients' conditions and operating room settings. Further, it is unclear if a reduction in the complications stems from the use of SSC or the algorithms for performing procedures it contains. The consensus arises that SSC should be periodically updated so that it would catch up with the advances in medical knowledge and the emerging technologies, which would safeguard the SSC from becoming just another paperwork nuisance for the operating room staff.

Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by symmetrical arthritis, and deterioration of articular cartilage and epiphyses leading to progressive destruction and deformation of joints, resulting in disability. The purpose of this chapter is to evaluate the effects of treatment with anti-inflammatory biologic medication, Enbrel (Etanercept), during therapeutic rehabilitation in RA patients. The sample comprised 10 hospitalized patients (8 females and 2 males) of the mean age of 32.2 ± 13.4 years treated with Enbrel in 2008-2010. The drug was administered subcutaneously in a dose of 50 mg once a week. Outcomes consisted of differences in the Disease Activity Score (DAS-28) and the degree of joint impairment based on the Health Assessment Questionnaire (HAQ) noted 2 months after treatment onset. The average pre-/post-treatment DAS-28 score was 4.1/2.6, with improvement in 9 patients. The average HAQ score was 1.5/0.6, respectively. We conclude that treatment with Enbrel significantly reduces RA activity and improved joint impairment. The beneficial influence of the drug enabled an earlier commencement of physical rehabilitation, which may have a preventive bearing on the development of disability.

Surgical Safety Checklist: Polychromatic or Achromatic Design.

The Surgical Safety Checklist (SSC) has been created based on the recommendations of the WHO and obligatorily introduced worldwide. SSC is used to increase the patient's safety and reduce complications while in the hospital, especially in the perioperative period. The original SSC template was of a multicolor polychromatic design. However, an achromatic black-and-white or gray-gray design on plain printer paper appears often used in clinical practice. This review aims to assess the level of SSC use in the polychromatic versus achromatic versions and the pros and cons of using either in practice. We used the Google browser for the identification and collection of SSC graphic images available as of June 2021 using the following search commands: "surgical safety checklist WHO" or "surgical safety checklist" or "SSC WHO." The commands were repeated in 103 languages representing the five continents with the back answers provided in 41 languages. The successive top 10 thematically relevant images or fewer if not available in the cases of some foreign languages were considered for analysis, providing a mean of 5 ±2 images per language. The numbers of achromatic and polychromatic two-color or multicolor images were calculated. The number of images corresponding to the respective color designs ranged as follows: 0-6 (27.6%), 0-9 (41.6%), and 0-6 (27.6%) We conclude that polychromatic imaging of SSC documents predominates in practical use. The polychromatic SSC design catches the doctor's eye, which likely increases the effectiveness of completing the document.

Differential evolution and cost-maps for needle path planning in Baker's cyst aspiration.

PURPOSE: The Baker's cysts appear within the popliteal fossa along with the progression of degenerative changes. Removal of its contents through aspiration is often a necessary complement to treatment at various stages of the development of gonarthritis. METHODS: The paper presented a procedure for needle automatic needle path planning in cyst aspiration in transverse plane. The method was based on optimization and used a custom objective function, which utilized cost maps obtained from preprocessed, segmented images of the knee. The optimization was carried out with Differential Evolution. Furthermore, a preliminary sensitivity analysis was carried out. The obtained paths were compared to the reference paths proposed by an experienced surgeon. RESULTS: The procedure was tested on 165 numerical simulations. In all of the obtained paths, the needle successfully avoided crucial objects, such as veins, arteries and nerves. Furthermore, the overall travel distance in the joint was also minimized. When compared to the reference from the surgeon, 90% of the paths were almost the same or only slightly different. Furthermore, the remaining 10% of the generated paths were viable but different. CONCLUSION: Based on the obtained results, the proposed solution could be a viable solution for planning the aspiration of Baker's cyst.

Causes and Effects of Introducing Surgery Safety Checklist: A Review.

The medical treatment process, particularly surgery, is inescapably bound to potential complications or undesirable adverse events. This narrative review aims to present the causes and effects of the introduction of the WHO Surgery Safety Checklist (SSC), the use of which is expected to reduce the number of perioperative errors, complications, and mortality. To achieve this objective, we performed a bibliometric analysis of medical citations indexed in the PubMed database using the SSC subject heading. Findings revealed a total of 1441 articles meeting inclusion status, with 1171 published during the last decade. After the screening of titles and abstracts, the members of the research team selected 75 articles, deemed most relevant for inclusion in the review, which were then thoroughly analyzed. All in all, the findings were that the use of SSC appreciably reduced the number of simple logistic errors in the perioperative period decreasing the frequency of resulting complications and mortality.

Artificial Intelligence in the Healthcare System: An Overview.

This chapter aims to present insights into the influence of artificial intelligence (AI) on medicine, public health, and the economy. PubMed and Google Scholar databases were used for the identification and collection of articles with search commands of "artificial intelligence" AND "public health" and "artificial intelligence" AND "medicine". A total of 273 articles specifically handling the issue of artificial intelligence, dating ten years back, in three major medical journals: Science, The Lancet, and The New England Journal of Medicine, were analyzed. Computational power gets stronger by the day, giving us new solutions and possibilities. Current medicine problems like personalized medicine, storage of data, and documentation overload will likely be replaced by AI shortly. The application of AI may also bring substantial benefits to other areas of medicine like the diagnostic and therapeutic processes. The development and spread of AI are inescapable as it lowers healthcare and administrative costs, improves medical efficiency, and predicts and prevents major disease complications. The use of AI in medicine seems destined to carry the day.

Smart homes for the older population: particularly important during the COVID-19 outbreak.

Osteoporosis, one of the leading causes of disability in older adults, significantly reduces the quality of life and leads to loss of independence. Dynamic development of "smart" solutions based on artificial intelligence more and more commonly applied in older people's houses may be an answer to the above issues. The aim of this study is to present selected "smart home" solutions for the diagnosis and prevention of falls in the older population through a literature review. The conducted meta-analysis based on a review of the scientific literature available in English and Polish in the Medline/PubMed, Embase, Scopus, and GBL databases was undertaken from 01.01.2015 to 01.10.2020 with the string search method using key words. According to the authors of this study, the development of new technology based on artificial intelligence allows older people to live independently, which contributes to a higher level of life satisfaction and quality.

Falls as One of the Atypical Presentations of COVID-19 in Older Population.

INTRODUCTION: Studies revealed COVID-19 atypical symptoms such as falls, delirium, confusion, dizziness, unusual fatigue in older patients. Falls in the older population and their consequences are one of the leading causes of disability; they significantly reduce the quality of life and lead to loss of independence and impaired social functioning. The aim of this study is to present the possible correlation between COVID-19 and diseases of the musculoskeletal system, in particular the occurrence of fall-related injuries. SIGNIFICANCE: This article highlights the importance of falls as one of the atypical symptoms of COVID-19 infection in older adults, which is not directly associated with infection and could be misinterpreted. METHODS: The conducted meta-analysis is based on a review of the scientific literature available in English, French, Dutch, Polish in the PubMed/MEDLINE, Cochrane Library, Embase, Scopus, PEDro, GBL databases from December 1, 2019 to July 30, 2020, covering Clinical Trial, Randomized Controlled Trial, Meta-Analysis, Systematic Reviews and Case Reports. The following keywords were taken into account: fall, (hip/pertrochanteric/proximal femur) fracture, aged and COVID-19. Twenty-seven references were accepted for final analysis. RESULTS: It was found that symptoms such as falls observed in the older adults can be associated with COVID-19 infection. Falls and slips are also the most common mechanism for hip fracture during the pandemic outbreak. CONCLUSIONS: According to authors of this study, atypical presentations of COVID-19 should be considered when screening and testing the people at increased risk due to their age. However, further prospective studies are urgently needed to investigate the possible correlation between COVID-19 and falls in older adults.

Overload of Medical Documentation: A Disincentive for Healthcare Professionals.

This review addresses the theories concerning the development and functioning of medical bureaucracy creating an excess of the patient records. An ever-growing number of medical files comply with the typical development of the bureaucratic management of an entrepreneurial organization, an essential feature of which is the life cycle of documentation. When the life cycle ends, an update is created with a multiplication of forms and items to be filled out, resembling that of what happens with the outdated computer program. Yet medical records should have a logical and well-functioning structure using the language of computer science in the form of a cascade or evolutionary model. Further, we believe that mass computerization, in contradistinction to the primary predestination purpose, increases the number of time-consuming medical records, with the evidence that it enhances the occupational burnout among physicians. Clear and concise medical documentation is necessary to handle economic and legal issues in medicine. However, the creation of medical records sits at the crux between a health-conscious provision of the best evidence-driven treatment and the continuum of care and a potential health detriment caused by taking away the time and care devoted to the patient by healthcare professionals. We submit that the hitherto pattern of creating medical records requires a turnabout to attain the intended reasons and user-friendliness for practical ends.

In Silico Evaluation of Treatment of Periprosthetic Fractures in Elderly Patients After Hip Arthroplasty.

The aim of this study was to investigate the soundness of in silico finite element model (FEM) in the assessment of strain in the femur and in the components fixing the periprosthetic fracture in elderly patients after hip arthroplasty. From a group of 55 patients, aged 27-95, treated due to fractures after hip replacement in 2012-2018, 18 patients were separated out, aged over 85, out of whom 7 had type C fractures, according to the Vancouver classification. These seven patients formed the study group. The fractures were stabilized with a locking compression plate system and wire loops or by replacement of the endoprosthesis stem. The FEM was performed by processing radiological images of the femur, considering the stabilization type and osteoporotic bone characteristics. Each patient's FEM was counter compared to virtual in silico control showing a non-osteoporotic bone structure. We found that the strain was distinctly greater at the bone-implant interface after surgical stabilization with a multi-hole plate and cerclage wire loops in osteoporotic periprosthetic fractures when compared to the virtual non-osteoporotic bone. We conclude that the in silico model enables the assessment of strain distribution at the bone-implant interface, which helps identify the biomechanical incongruity of traditional bone stabilization methods in patients with osteoporotic bones.

Shortage of Physicians: A Critical Review.

A recent report of the Organization for Economic Co-operation and Development (OECD) points out an insufficient number of physicians in Europe. The issue seems especially relevant in the face of the COVID-19 pandemic. In this review, based on papers found in the PubMed database, we drew on the available information on the aspects of medical education and terms and rate of employment of physicians to submit potential solutions of how to increase the availability of physicians in Europe. We offer the following improvements in tackling the issue: (i) standardization of the method of verification of the number of physicians in practice for a meaningful comparison between European states; (ii) managerial reorganization of medical education to increase the flexibility of teaching; (iii) education shortening, e.g., to 4 years, for nurses, paramedics, and the like; (iv) circumscription of unnecessary health records and the use of artificial intelligence to streamline the recording system to ease the burden on the medical staff.