1.
Org Lett
; 24(15): 2832-2836, 2022 Apr 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35394282
RESUMO
A copper-catalyzed 1,4-protosilylation of α-alkynyl-enones to form the functionalized chiral homoallenylsilanes was developed. In the presence of a chiral monopyridine oxazoline ligand, a variety of trisubstituted allene derivatives bearing a contiguous stereogenic center and axis were prepared in good yields with excellent enantioselectivities and diastereoselectivities.