Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading: A mechanistic study.

The successful application of magnesium (Mg) alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity. This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks' Balanced Salt Solution (HBSS) with and without in situ cyclic compression (30 N/1 Hz). The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation. Although in situ cyclic compression induced acceleration of the corrosion rate, probably due to local disruption of the coating layer where fatigue microcracks were formed, no critical failures in the overall scaffold were observed, indicating that the mechanical integrity of the Mg scaffolds was preserved. Structural changes, due to the accumulation of corrosion debris between the scaffold fibres, resulted in a significant increase (p < 0.05) in the material volume fraction from 0.52 ± 0.07 to 0.47 ± 0.03 after 14 days of corrosion. However, despite an increase in fibre material loss, the accumulated corrosion products appear to have led to an increase in Young's modulus after 14 days as well as lower third principal strain (εp3) accumulation (-91000 ± 6361 µÎµ and -60093 ± 2414 µÎµ after 2 and 14 days, respectively). Therefore, this innovative Mg scaffold design and composition provide a bone replacement, capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs.

Effect of Fibre Orientation on Impact Damage Resistance of S2/FM94 Glass Fibre Composites for Aerospace Applications: An Experimental Evaluation and Numerical Validation.

This study aims to investigate the influence of fibre orientation and varied incident energy levels on the impact-induced damage of S2/FM94, a kind of aerospace glass fibre epoxy/composite regularly used in aircraft components and often subjected to low-velocity impact loadings. Effects of varying parameters on the impact resistance behaviour and damage modes are evaluated experimentally and numerically. Laminates fabricated with four different fibre orientations 0/90/+45/-458s, 0/90/90/08s, +45/-4516s, and  032 were impacted using three energy levels. Experimental results showed that plates with unidirectional fibre orientation failed due to shear stresses, while no penetration occurred for the 0/90/90/08s and +45/-4516s plates due to the energy transfer back to the plate at the point of maximum displacement. The impact energy and resulting damage were modelled using Abaqus/Explicit. The Finite Element (FE) results could accurately predict the maximum impact load on the plates with an accuracy of 0.52% to 13%. The FE model was also able to predict the onset of damage initiation, evolution, and the subsequent reduction of the strength of the impacted laminates. The results obtained on the relationship of fibre geometry and varying incident impact energy on the impact damage modes can provide design guidance of S2/FM94 glass composites for aerospace applications where impact toughness is critical.

Spatial resolution and measurement uncertainty of strains in bone and bone-cement interface using digital volume correlation.

The measurement uncertainty of strains has been assessed in a bone analogue (sawbone), bovine trabecular bone and bone-cement interface specimens under zero load using the Digital Volume Correlation (DVC) method. The effects of sub-volume size, sample constraint and preload on the measured strain uncertainty have been examined. There is generally a trade-off between the measurement uncertainty and the spatial resolution. Suitable sub-volume sizes have been be selected based on a compromise between the measurement uncertainty and the spatial resolution of the cases considered. A ratio of sub-volume size to a microstructure characteristic (Tb.Sp) was introduced to reflect a suitable spatial resolution, and the measurement uncertainty associated was assessed. Specifically, ratios between 1.6 and 4 appear to give rise to standard deviations in the measured strains between 166 and 620 µÎµ in all the cases considered, which would seem to suffice for strain analysis in pre as well as post yield loading regimes. A microscale finite element (µFE) model was built from the CT images of the sawbone, and the results from the µFE model and a continuum FE model were compared with those from the DVC. The strain results were found to differ significantly between the two methods at tissue level, consistent in trend with the results found in human bones, indicating mainly a limitation of the current DVC method in mapping strains at this level.

Characterisation of a metallic foam-cement composite under selected loading conditions.

An open-cell metallic foam was employed as an analogue material for human trabecular bone to interface with polymethyl methacrylate (PMMA) bone cement to produce composite foam-cement interface specimens. The stress-displacement curves of the specimens were obtained experimentally under tension, shear, mixed tension and shear (mixed-mode), and step-wise compression loadings. In addition, under step-wise compression, an image-guided failure assessment (IGFA) was used to monitor the evolution of micro-damage of the interface. Microcomputed tomography (µCT) images were used to build a subject-specific model, which was then used to perform finite element (FE) analysis under tension, shear and compression. For tension-shear loading conditions, the strengths of the interface specimens were found to increase with the increase of the loading angle reaching the maximum under shear loading condition, and the results compare reasonably well with those from bone-cement interface. Under compression, however, the mechanical strength measured from the foam-cement interface is much lower than that from bone-cement interface. Furthermore, load transfer between the foam and the cement appears to be poor under both tension and compression, hence the use of the foam should be discouraged as a bone analogue material for cement fixation studies in joint replacements.

A subject-specific pelvic bone model and its application to cemented acetabular replacements.

A subject-specific three-dimensional finite element (FE) pelvic bone model has been developed and applied to the study of bone-cement interfacial response in cemented acetabular replacements. The pelvic bone model was developed from CT scan images of a cadaveric pelvis and validated against the experiment data obtained from the same specimen at a simulated single-legged stance. The model was then implanted with a cemented acetabular cup at selected positions to simulate some typical implant conditions due to the misplacement of the cup as well as a standard cup condition. For comparison purposes, a simplified FE model with homogeneous trabecular bone material properties was also generated and similar implant conditions were examined. The results from the homogeneous model are found to underestimate significantly both the peak von Mises stress and the area of the highly stressed region in the cement near the bone-cement interface, compared with those from the subject-specific model. Non-uniform cement thickness and non-standard cup orientation seem to elevate the highly stressed region as well as the peak stress near the bone-cement interface.