RESUMO
Several studies have shown that major depression is accompanied by significantly increased plasma levels of positive acute-phase proteins such as haptoglobin (Hp). A significant higher frequency of the HP*1 allele has recently been detected in patients with unipolar major depression. Pursuing the hypothesis that certain unipolar and bipolar disorders may be genetically related, this study analyzed Hp genotype and allele frequencies in bipolar patients, taking into account their family history of major affective disorders. An increase of HP*1 allele frequency was found in the subgroup of patients with family history of exclusively unipolar disorder (70% in patients vs. 38% in controls, chi2 = 8.34, p = 0.004). The relative risk for the HP*1 carriers in this subgroup was 3.8 (chi2 = 7.29, p = 0.007). These results suggest a genetic and etiological heterogeneity in the bipolar disorder.
Assuntos
Transtorno Bipolar/genética , Haptoglobinas/genética , Alelos , Transtorno Bipolar/sangue , Feminino , Frequência do Gene , Humanos , Masculino , Fenótipo , Polimorfismo Genético/genéticaRESUMO
By this investigation we want to contribute to our knowledge on the genetic characteristics of the Corsican population. The distribution of seven genetic serum protein markers (PI, TF, GC, ORM, HP, C3, PLG) was analyzed in a sample of 291 individuals coming from the central and northern areas of Corsica, i.e. from Corte and Bastia. The two samples do not show significant differences in the distribution of the genetic markers under study. The comparisons with other Mediterranean populations confirm the results of previous investigations on genetic red cell enzyme markers (Vona et al. 1995), i.e. a relatively high genetic heterogeneity of Corsicans compared with other Mediterranean populations.
Assuntos
Proteínas Sanguíneas/genética , Marcadores Genéticos/genética , Variação Genética , Genética Populacional , Adulto , Feminino , França , Frequência do Gene/genética , Humanos , Masculino , FenótipoRESUMO
The variation in the third component of human complement (C3) and orosomucoid (ORM1) serum proteins, and 6-phosphogluconate dehydrogenase (6PGD), adenosine deaminase (ADA), esterase D (ESD), and acid phosphatase (ACP1) red cell enzymes was examined in two samples from autochthonous populations living on either side of the Sierra de Gredos range in Central Spain. These results support only a moderate differentiation between Gredos subpopulations, which is discussed in relation to other Iberian Peninsula groups. Allele frequencies in Gredos show a remarkable heterogeneity as contrasted with other Iberian populations for most of the markers examined; relatively high C3*S, ORM1*F, ADA*1, ESD*2, and ACP1*C gene frequencies are characteristics of Gredos samples. This differentiation was more marked for the Northern Gredos population and could be related to the geographical peculiarities of this region.