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1.
Bull Exp Biol Med ; 168(5): 618-620, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32246363

RESUMO

We studied the effect of peptide drugs deltalicin and Semax on lipid metabolism disturbances in diabetes mellitus. Diabetes mellitus was modeled by single injection of streptozotocin (45 mg/kg) and rats with blood glucose ≥12 mmol/liter were selected for the further experiments. Deltalicin in a dose 100 µg/kg and Semax in a dose 200 µg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. Deltalicin produced more potent effect on lipid metabolism in rats with diabetes mellitus than sulodexide and Semax, which manifested in a significant decrease in total cholesterol and LDL concentration and index of atherogenicity.


Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Hipolipemiantes/uso terapêutico , Transtornos do Metabolismo dos Lipídeos/tratamento farmacológico , Peptídeos/uso terapêutico , Hormônio Adrenocorticotrópico/análogos & derivados , Hormônio Adrenocorticotrópico/uso terapêutico , Animais , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/complicações , Diabetes Mellitus Experimental/metabolismo , Glicosaminoglicanos/farmacologia , Glicosaminoglicanos/uso terapêutico , Metabolismo dos Lipídeos/efeitos dos fármacos , Transtornos do Metabolismo dos Lipídeos/complicações , Masculino , Fragmentos de Peptídeos/uso terapêutico , Ratos , Ratos Wistar , Estreptozocina
2.
Bull Exp Biol Med ; 167(1): 47-49, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31177448

RESUMO

We studied the influence of synthetic indolicidin analogues on the development of acute periodontitis. The corrective effect was found in indolicidin analogues Nos. 7 and 8; it manifested in a decrease in the edema of gingival epithelium and lamina propria, a decrease in the relative area of inflammatory infiltrates, and a significant increase in the relative area of normal connective tissue. These changes were revealed as soon as on day 14 and were most pronounced in 21 days after the removal of the ligature. Indolicidin analogues Nos. 7 and 8 demonstrated similar effectiveness on the model of acute periodontitis.


Assuntos
Peptídeos Catiônicos Antimicrobianos/uso terapêutico , Periodontite/tratamento farmacológico , Animais , Peptídeos Catiônicos Antimicrobianos/química , Tecido Conjuntivo/efeitos dos fármacos , Tecido Conjuntivo/metabolismo , Gengiva/citologia , Gengiva/metabolismo , Mucosa/efeitos dos fármacos , Mucosa/metabolismo , Ratos Wistar
3.
Bull Exp Biol Med ; 162(3): 313-315, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28091903

RESUMO

Blood levels of nonesterified fatty acids, total cholesterol, triglycerides, and LDL increased in rats subjected to forced swimming stress. Administration of opioid peptides dynorphin A(1-13), DSLET, or DAGO reduced stress-induced disturbances in lipid metabolism. Dynorphin A(1-13) and DAGO produced the most pronounced effects and prevented an increase in concentrations of nonesterified fatty acids, triglycerides, total cholesterol, and LDL as soon as 39 h after treatment. Only DSLET increased HDL content in the plasma of stressed rats. The observed effects can be explained by the stress-limiting effects of opioids, e.g. attenuation of the effect of catecholamines on the adipose tissue and inhibition of the generation LPO products suppressing activity of the cholesterol metabolizing enzyme.


Assuntos
Analgésicos Opioides/farmacologia , Dinorfinas/farmacologia , Ala(2)-MePhe(4)-Gly(5)-Encefalina/farmacologia , Encefalina Leucina/análogos & derivados , Metabolismo dos Lipídeos/efeitos dos fármacos , Fragmentos de Peptídeos/farmacologia , Estresse Psicológico/sangue , Animais , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Encefalina Leucina/farmacologia , Ácidos Graxos não Esterificados/sangue , Masculino , Ratos , Ratos Wistar , Estresse Psicológico/tratamento farmacológico , Estresse Psicológico/fisiopatologia , Natação , Triglicerídeos/sangue
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