[Predictive value of prognostic inflammatory and tumor score in intrahepatic cholangiocarcinoma].

Objective: To compare and analyze the predictive value of different inflammatory factors and tumor markers in intrahepatic cholangiocarcinoma and to develop a new and effective preoperative prognostic scoring system. Methods: 102 and 72 cases with intrahepatic cholangiocarcinoma who underwent radical surgery in Tianjin Medical University Cancer Institute and Hospital and the Affiliated Hospital of Weifang Medical University were selected as the experimental group and the validation group, respectively. Clinicopathological and follow-up data were collected. Cox proportional-hazards model was used to analyze the predictive value of different prognostic markers. The relationship between prognostic markers and clinicopathological data was analyzed by rank sum test, χ2 or Fisher's exact test. Results: Among the direct inflammatory factors, tumor markers and combined inflammatory factors, prognostic inflammatory index (PII), carbohydrate antigen (CA) 19-9 and systemic inflammation score (SIS) were the most significant predictive factors for postoperative survival outcomes in patients with intrahepatic cholangiocarcinoma. The prognostic inflammatory and tumor score (PITS) was proposed as a new prognostic scoring system for intrahepatic cholangiocarcinoma. PII and CA19-9 were included into the scoring criteria for prognostic stratification of patients. PITS was an independent predictor of tumor-free survival and overall survival in patients with intrahepatic cholangiocarcinoma. Patients with high-grade PITS had later tumor grade and higher frequency of vascular invasion. Conclusion: PITS is highly effective prognostic scoring system for patients with intrahepatic cholangiocarcinoma. In addition, PITS is recommended for preoperative prognostic stratification in patients with intrahepatic cholangiocarcinoma.

Variable dimensionality from mononuclear and trinuclear to one and two dimensions: a series of copper(II) compounds with 4,4'-dipyridine dioxide.

Reaction of 4,4'-dipyridine dioxide (dpdo) and CuCl(2).6H(2)O in aqueous solution gave an adduct [Cu(H(2)O)(6)]Cl(2).2dpdo.2H(2)O 1, which has a hydrogen-bonded three-dimensional network. While substituting CuCl(2).6H(2)O with Cu(ClO(4))(2).6H(2)O, three pseudopolymorphs, namely, [Cu(dpdo)(6)][ClO(4)](2) 2, [Cu(3)(dpdo)(8)(H(2)O)(6)][ClO(4)](6).2dpdo.6H(2)O 3, and [Cu(dpdo)(H(2)O)(4)][ClO(4)](2).2dpdo 4, were isolated. 2 consists of a mononuclear copper coordinated with six terminal dpdo ligands. Adjacent mononuclear units are overlapped through pi-pi stacking of pyridine rings to give a 2D sheet with a triangular channel. 3 forms a trinuclear cluster bridged by two dpdo molecules. The solvate and terminal dpdo molecules are interwoven through hydrogen bonding and pi-pi stacking to lead to a rectangular channel with a dimensionality of 12.98 A x 13.44 A. 4 has a one-dimensional chain structure bridged by dpdo. Two solvate dpdo ligands link these chains through hydrogen bonding to generate two sets of three-dimensional networks which are interwoven through a common conjunctive point [Cu(H(2)O)(4)](2+), yielding a three-dimensional open framework with triangular channels. ClO(4)(-) anions are included within these channels in 2-4 through weak C-H...O hydrogen bonding. The introduction of the second spacer, 4,4'-bipyridine, generated a 2D architecture [Cu(dpdo)(4,4'-bipy)][ClO(4)](2).2H(2)O.dpdo 5, which is constructed by 4,4'-bipy and 4,4'-dpdo simultaneously, exhibiting a large channel with approximate dimensionality 11.1 A x 12.6 A, in which solvate 4,4'-dpdo ligand and perchlorate anions are accommodated.

Structures and magnetism of two novel heptanuclear lanthanide-centered trigonal prismatic clusters: [LnCu6(mu 3-OH)3(HL)2(L)4](ClO4)2.25H2O (Ln = La, Tb; H2L = iminodiacetic acid).

The new heteronuclear iminodiacetic acid (H2L) complexes [LnCu6(mu 3-OH)3(HL)2(L)4](ClO4)(2).25H2O with Ln = La (1) and Tb (2) have been prepared in aqueous solution and characterized by single-crystal X-ray diffraction to be isomorphous (crystallographic data for 1 and 2: hexagonal, P63/m; a = b = 12.6425(14) A, c = 24.541(5) A, Z = 2 (1); a = b = 12.5802(9) A, c = 24.285(4) A, Z = 2 (2)). Ln3+ was found to be located in the center of the trigonal prismatic cage formed by six Cu2+ ions, with a tricapped trigonal prismatic coordination environment of nine O atoms. The magnetic properties of complexes 1 and 2 have been studied. The results indicate the presence of ferromagnetic couplings between Tb3+ and Cu2+ in compound 2.