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Lung cancer is a leading cause of cancer-related mortality worldwide, profoundly affecting patients' quality of life. Patient-reported outcomes (PROs) provide essential insights from the patients' perspective, a crucial aspect often overlooked by traditional clinical outcomes. This review synthesizes research on the role of PROs in lung cancer surgery to enhance patient care and outcomes. We conducted a comprehensive literature search across PubMed, Scopus, and Web of Science up to March 2024, using terms such as "lung cancer," "Patient Reported Outcome," "lobectomy," "segmentectomy," and "lung surgery." The criteria included original studies on lung cancer patients who underwent surgical treatment and reported on PROs. After screening and removing duplicates, reviews, non-English articles, and irrelevant studies, 36 research articles were selected, supported by an additional 53 publications, totaling 89 references. The findings highlight the utility of PROs in assessing post-surgical outcomes, informing clinical decisions, and facilitating patient-centered care. However, challenges in standardization, patient burden, and integration into clinical workflows remain, underscoring the need for further research and methodological refinement. PROs are indispensable for understanding the quality-of-life post-surgery and enhancing communication and decision-making in clinical practice. Their integration into routine care is vital for a holistic approach to lung cancer treatment, promising significant improvements in patient outcomes and quality of care.
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BACKGROUND: Nursing job competency is critical for talent development both globally and in China, relating to work readiness and transition shock. Previous studies, which have typically relied on average measurements at fixed time points, have not provided comprehensive longitudinal insights. AIM: This study aimed to investigate the developmental trajectories of transition shock in new nurses at oncology specialty hospitals. Furthermore, we sought to explore the longitudinal mediating role of transition shock in the relationship between work readiness and the development of nursing job competency. DESIGN: Longitudinal follow-up study. METHODS: We conducted three follow-up surveys over 8 months using the Work Readiness Scale, the Transition Shock Scale, and the Nursing Job Competency Scale to assess 252 novice nurses at two high-volume oncology centers. The surveys were conducted at 0, 4, and 8 months, with demographic information collected during the first survey. Data were analyzed using R 4.1.2 and Mplus 8.0. RESULTS: (1) Over the 8-month period, transition shock exhibited a linear decrease. Notably, nurses with a higher initial transition shock experienced a slower rate of decline. (2) There were positive correlations between work readiness and nursing job competency at all three measurement points. Conversely, transition shock was negatively correlated with both work readiness and nursing job competency. (3) Transition shock functioned as a longitudinal mediator in the relationship between work readiness and nursing job competency. CONCLUSION: This study clarified the longitudinal mediating role of transition shock in the relationship between work readiness and job competency in oncology settings. Targeted interventions are necessary to mitigate excessive transition shock, thereby improving the nursing job competency of new nurses in oncology hospitals. REGISTRATION: 23/313-4055.
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PURPOSE: We aimed to investigate cancer patients' experiences of psychological distress after surgery and the factors that influence it, and to analyze the relationship between this and the nursing humanistic care demands. METHODS: This study used a convenience sampling method to survey 432 cancer patients undergoing surgical treatment in the specialized cancer hospital in Beijing. The survey used socio-demographic information, the Distress Management Screening Measures, and the Nursing Humanistic Care Demands questionnaire. Questionnaire Star was used to collect data online. SPSS24.0 software was used to test the relationship between psychological distress and nursing humanistic care demands. RESULTS: The mean scores for psychological distress and nursing humanistic care demands were 3.95 ± 2.71 and 147.02 ± 19.88, respectively, and showed a moderately positive correlation. The main issues that caused psychological distress in patients were: worry, financial problems, surroundings, nervousness, sleep, and pain. Regression analysis showed that gender, financial burden, personality trait, and need for humanistic care in nursing explained 24.5% of the total variance in the model and were independent predictors of psychological distress. CONCLUSION: Cancer inpatients have significant psychological distress after surgery and exhibit high levels of nursing humanistic care demands. This study fills the research gap on humanistic care for psychological distress management, nursing humanistic care demands positively predicted psychological distress. Nursing staff should pay attention to the psychological suffering of patients and develop individualized care measures to alleviate their psychological suffering by accurately identifying their nursing humanistic care demands.
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AIMS: To explore the current situation, influencing factors and pathways of safety behaviour of nurses in tumour specialized hospitals, in order to provide a theoretical basis for managers to manage and train nurses, improve their safety behaviour level and ensure medical safety. DESIGN: An anonymous cross-sectional survey. METHOD: A total of 2147 nurses from Grade A cancer hospitals in 15 provinces of China were selected by a convenient sampling method. Questionnaires were collected through the Questionnaire Star platform. Nurses' safety behaviour was measured using the nurse Safety Behaviour Scale, Self-efficacy by the General Self-efficacy Scale, and nurses' occupational burnout was measured by the occupational Burnout Scale, and work engagement through the the Work Engagement Scale. Structural equation modelling was used to test the relationship among nurses' safety behaviour, general self-efficacy, occupational burnout and work engagement. SPSS25.0 software was used to test the relationship among the safety behaviour of nurses, general self-efficacy, occupational burnout and work engagement. RESULTS: The total score of safety behaviour of nurses was 55.45 ± 6.879, the total score of general self-efficacy was 31.39 ± 5.729, the total score of occupational burnout was 44.99 ± 26.587, and the total score of work engagement was 38.48 ± 13.433; the scores of the Nurse Safety Behaviour Scale, Self-Efficacy Scale, and Work Engagement Scale were positively correlated (all p < .001); the occupational burnout scale was negatively correlated with the scores of self-efficacy scale, work engagement scale and nurse safety behaviour scale (all p < .001); Structural equation model analysis shows that self-efficacy and work engagement have a direct positive impact on nurse safety behaviour(ß = .103, ß = .096, all p < .001); Occupational burnout has a direct negative impact on self-efficacy, work engagement and nurse safety behaviour(ß = -.371, ß = -.413, ß = -.328 all p < .001). Bootstrap analysis showed that occupational burnout and job involvement had a significant chain mediating effect between self-efficacy and the safety behaviour of nurses (95% CI: 0.148-0.21). The total effect of self-efficacy on the safety behaviour of nurses was 0.283 (p < .001, 95% CI: 0.225-0.301), the direct effect was 0.096 (p < .001, 95% CI: 0.042-0.15), and the indirect effect was 0.179 (p < .001, 95% CI: 0.085-0.215), The mediating effect accounted for 63.3% of the total effect size. CONCLUSION: Occupational burnout and work engagement play a partial mediating role between self-efficacy and nurse safety behaviour. It is necessary to strengthen training on nurse safety culture awareness, improve the nurse self-efficacy and work engagement, reduce nurse occupational burnout, and thereby improve the level of nurses' safety behaviour.
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Esgotamento Profissional , Enfermeiras e Enfermeiros , Humanos , Autoeficácia , Estudos Transversais , Modelos Teóricos , Inquéritos e Questionários , Engajamento no Trabalho , Satisfação no EmpregoRESUMO
BACKGROUND: Newly graduated nurses face a dilemma of transitioning from student to clinical nurse roles, resulting in a low level of work readiness. The special professional environment of oncology hospitals requires newly graduated nurses to have specialized and novel theoretical knowledge and nursing skills. Therefore, they are constantly expected to develop better core competence. However, whether the core competence of newly graduated nurses mediates the relationship between transition shock and work readiness has not been investigated. OBJECTIVE: This study examined the relationship among transition shock, core competence, and work readiness of newly graduated nurses in cancer hospitals. DESIGN: A descriptive, cross-sectional study design. SETTING: This study was conducted at a tertiary cancer hospital in Beijing. PARTICIPATIONS: A convenience sample of 188 newly graduated nurses was studied from July to August 2022. METHODS: Sociodemographic data and Transition Shock Scale for Newly Graduated Nurses, Work Readiness Scale for Newly Graduated Nurses, and Core Competence Scale scores were collected using the online Questionnaire Star support platform. Pearson correlation and multiple regression analysis were applied using the Statistical Package for the Social Sciences version 24 to test the relationship among transition shock, core competencies, and work readiness. The Analysis of Moment Structures version 24.0 software was used to construct structural equation models. This report followed the Strengthening the Reporting of Observational studies in Epidemiology checklist. RESULTS: The transition shock of newly graduated nurses was negatively correlated with work readiness and core competence, whereas core competence was positively correlated with work readiness. Core competence partially mediated the effect between transition shock and work readiness, accounting for 19 % of the total effect. CONCLUSION: Core competence is the mediating variable between transition shock and work readiness of newly graduated nurses in oncology hospitals. During the transition period of newly graduated nurses, clinical nursing managers and teachers should pay attention to cultivating the core competence of newly graduated nurses to improve their work readiness.
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Neoplasias , Enfermeiras e Enfermeiros , Humanos , Estudos Transversais , Institutos de Câncer , Papel do Profissional de Enfermagem , Análise Multivariada , Inquéritos e QuestionáriosRESUMO
PURPOSE: To study the level of fear of cancer recurrence (FCR) in patients receiving surgery for non-small cell lung cancer (NSCLC) and explore related factors that can increase levels of hope in this population, enhance the confidence to defeat the disease, and thus increase the quality of life. METHODS: A total of 327 postoperative NSCLC patients from the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were enrolled. All participants completed the General Questionnaire, Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Herth Hope Index (HHI) Scale, and Social Support Rating Scale (SSRS). RESULTS: The mean FoP-Q-SF score was (30.3 ± 9.48) points in postoperative NSCLC patients, Among them, there were 188 patients (57.5%) who had psychological dysfunction, indicated by a score of > / = 34. Patient sex and family income were independent risk factors for FCR (both p < 0.05). Correlation analysis revealed a negative association between FCR and hope level (p < 0.05) and a positive association between hope level and social support (p < 0.05). Notably, social support mediated the association between FCR and hope in patients receiving surgery for NSCLC (contribution effect: 30.24%). CONCLUSION: Postoperative NSCLC patients experience a moderate level of FCR, especially females and those with a low family income. Social support partially mediates the relationship between FCR and hope in this population. Therefore, an increase in the level of social support can increase hope among these patients and advancing recovery.
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Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Feminino , Humanos , Qualidade de Vida , Carcinoma Pulmonar de Células não Pequenas/cirurgia , Recidiva Local de Neoplasia/epidemiologia , Recidiva Local de Neoplasia/psicologia , Neoplasias Pulmonares/cirurgia , Medo/psicologia , Apoio Social , Inquéritos e QuestionáriosRESUMO
PURPOSE: Discuss the application effect of the six-step standard communication process in the communication ability training of newly recruited nurses. METHODS: This is a before and after control study. The control group included 45 newly recruited nurses in our hospital in 2019, and the observation group included 40 newly recruited nurses in our hospital in 2020. The control group completed the training according to the existing communication training program, and the observation group implemented a training program based on the "six-step standard communication process" on the basis of the existing communication training. The training period was 12 months. The training effect of the two groups of new nurses was compared. RESULTS: After training, the total scores of clinical communication skills of the new nurses in the control group and observation group were 252.56 ± 24.950 and 268.05 ± 19.335 points, respectively; the total scores of communication behavior were 39.00 ± 4.676 and 48.08 ± 2.515 points, respectively; the total scores of general self-efficacy were 26.89 ± 3.017 and 31.25 ± 5.027 points, respectively; the satisfaction scores of communication training were 17.56 ± 2.018 and 19.45 ± 0.986 points, respectively, and the differences were statistically significant (P < 0.05). CONCLUSION: The implementation of a training program based on the "six-step standard communication process" can effectively improve the clinical communication skills and self-efficacy of newly recruited nurses, and can be promoted and applied to the communication training of newly recruited nurses.
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A novel direct dual Z-scheme 3DOM (three-dimensional ordered macropores) SnS2-ZnS/ZrO2 composite was prepared by the template method combined with the in situ sulfur replacement technology. The composition, structure, morphology, and surface physicochemical properties of the composites were well characterized. The results indicate that it possesses a uniform and periodical macroporous structure, a large surface area (121.1 m2 g-1), broad visible light absorption, and high separation ability of photoinduced electron/hole pairs. 3DOM SnS2-ZnS/ZrO2 composite removed 96.8% of methyl orange within 210 min of simulated sunlight irradiation. Moreover, photocatalytic hydrogen production achieved the rate of 928.1 µmol g-1, which was 66.3 times as high as that of the commercial P25 after 8 h simulated sunlight irradiation. The enhanced photocatalytic performance mainly attributed to the direct dual Z-scheme system, which improves the charge separation efficiency and optimizes the charge transfer pathway. The charge transfer mechanism over the 3DOM SnS2-ZnS/ZrO2 is discussed in detail based on the results of radical trapping experiments. Our work paves a new way to design 3DOM materials with direct dual Z-scheme structure.
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Sulfetos , Compostos de Zinco , Catálise , HidrogênioRESUMO
Novel Ag3PO4/Bi2WO6 heterostructured materials with enhanced visible-light catalytic performance were successfully synthesized by assembly combined with a hydrothermal treatment. The microstructures, morphologies, and optical properties of the prepared samples were characterized by multiple techniques. The irregular Ag3PO4 nanospheres dispersed on the surface of Bi2WO6 nanoflakes, and their catalytic performances were evaluated via the degradation of organic pollutants including rhodamine B (RB), methylene blue (MB), crystal violet (CV), methyl orange (MO), and phenol (Phen) under visible-light irradiation. The resulting Ag3PO4/Bi2WO6 heterostructured materials displayed higher photocatalytic activity than that of either pure Bi2WO6 or Ag3PO4. The enhanced photocatalytic activity was due to the good formation of heterostructures, which could not only broaden the spectral response range to visible light but also effectively promoted the charge separation. Meanwhile, the reasonable photoreactive plasmonic Z-scheme mechanism was carefully investigated on the basic of the reactive species scavenging tests, photoelectrochemical experiments, and photoluminescence (PL) spectrum. In addition, the excellent photostability of Ag3PO4/Bi2WO6 was obtained, which Ag formed at the early photocatalytic reaction acted as the charge transmission-bridge to restrain the further photoreduction of Ag3PO4.
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A series of hydroxyanthraquinones having an alkylating N-mustard pharmacophore at 1'-position were synthesized via a bioisostere approach to evaluate their cytotoxicity against four tumor cell lines (MDA-MB-231, HeLa, MCF-7 and A549). These compounds displayed significant in vitro cytotoxicity against MDA-MB-231 and MCF-7 cells, reflecting the excellent selectivity for the human breast cancer. Among them, compound 5k was the most cytotoxic with IC50 value of 0.263 nM and is more potent than DXR (IC50 = 0.294 nM) in inhibiting the growth of MCF-7 cells. The excellent cytotoxicity and good selectivity of compound 5k suggest that it could be a promising lead for further design and development of anticancer agents, especially for breast cancer.
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Antraquinonas/farmacologia , Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Desenho de Fármacos , Compostos de Mostarda Nitrogenada/síntese química , Compostos de Mostarda Nitrogenada/farmacologia , Antraquinonas/síntese química , Antraquinonas/química , Antineoplásicos/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Células HeLa , Humanos , Células MCF-7 , Estrutura Molecular , Compostos de Mostarda Nitrogenada/química , Relação Estrutura-AtividadeRESUMO
Taking polystyrene latex spheres (PS) and EO20PO70EO20 (P123) as dual templates, and TiO2 was used as substrate, a series of multi-layer three dimensionally ordered macroporous (3DOM) composites Bi2O3/TiO2 were successfully synthesized with sol-gel method and post-processing calcination. The fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), UV-vis diffuse reflectance (UV-vis/DRS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HR-TEM) and nitrogen adsorption-desorption measurements were employed to analyze the crystalline phase, chemical composition, morphology, and surface physicochemical properties of as-synthetized samples. The results showed that as-composites were provided with obvious crystalline phase structure and periodically highly uniform ordered macroporous structure with mesoporous walls; moreover, of which was multi-layer three dimensionally ordered structure. As a result of unique optical properties of Bi2O3 and composite material structural characteristic being propitious to reactant molecular transmission and diffusion, the photocatalytic activities of 3DOM Bi2O3/TiO2 were enhanced, and the sample 3DOM Bi2O3/TiO2-2 was significantly higher than that of direct photolysis, P25, Bi2O3, and other 3DOM Bi2O3/TiO2-X (X=1, 3, 4) during the photocatalytic degradation of crystal violet under multi-modes such as UV, visible light, simulated solar light, and microwave-assisted irradiation. The centrifugal samples water solution phase of TOC analysis indicated that water solution products formed with continued ultraviolet radiation, the intermediates eventually mineralized, volatilized, or were converted to other products. In addition, the photocatalytic activity of 3DOM Bi2O3/TiO2-2 composite was basically kept even after three cycles. Meanwhile, the possible photocatalytic reaction mechanism of as-synthesized material based on the experimental results was proposed.
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A series of mesoporous sulfated zirconia materials functionalized by alkyl-bridged organosilica moieties (SO(4)(2-)/ZrO(2)-SiO(2)(R) with various S/Si or Zr/Si molar ratios and R=CH(2)CH(2) or C(6)H(4)) were developed by a one-step co-condensation technique combined with hydrothermal treatment with the aid of a triblock copolymer surfactant (P123). The structures, morphologies, porosities, and acid properties of the materials were well characterized. Subsequently, the catalytic performances (activity and stability) of SO(4)(2-)/ZrO(2)-SiO(2)(R) were evaluated by the transesterification of both pure triglyceride (tripalmitin) and low-cost virgin plant oil (Eruca sativa Gars. oil) with methanol for biodiesel production under mild conditions (atmospheric pressure, 65 °C), and the enhanced catalytic activity with respect to alkyl-free sulfated zirconia was obtained. This excellent catalytic activity was explained in terms of the inherent Brønsted acidity, well-defined mesoporosity, and increased hydrophobicity of the as-prepared, hybrid, solid acid catalyst.
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Alcanos/química , Biocombustíveis , Compostos Organometálicos/síntese química , Compostos de Organossilício/química , Sulfatos/química , Zircônio/química , Biocombustíveis/provisão & distribuição , Catálise , Interações Hidrofóbicas e Hidrofílicas , Compostos Organometálicos/química , Porosidade , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
Heterostructured metallic silver-layered bismuth niobate two-component system (Ag/Bi(5)Nb(3)O(15)) was developed for the first time by a mild hydrothermal method combined with photodeposition. The Ag/Bi(5)Nb(3)O(15) exhibited single-crystalline orthorhombic structure with small particle size (50-200 nm) and octahedral as well as sheet-like shape; additionally, it possessed photoresponse in both UV and visible region. As a novel alternative photocatalysts to TiO(2), the photocatalytic activity of the Ag/Bi(5)Nb(3)O(15) was evaluated by the degradation of tetrabromobisphenol A, a member from the family of the brominated flame retardant, under solar simulating Xe lamp irradiation, and enhanced photocatalytic activity in compared to Bi(5)Nb(3)O(15) itself and Degussa P25 was obtained.
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Luz , Bifenil Polibromatos/química , Bifenil Polibromatos/efeitos da radiação , Bismuto/química , Catálise , Recuperação e Remediação Ambiental/métodos , Retardadores de Chama , Nanoestruturas/química , Prata/química , Luz SolarRESUMO
A series of porous polyoxotungstate/titania nanocomposites (PW(12)/TiO(2)) with particle size lower than 10nm and BET surface area of ca. 200 m(2)g(-1) was prepared by sol-gel chemistry combined with solvothermal treatment. The composites were successfully applied to the degradation of aqueous phthalate esters (PAEs) including di-n-butyl phthalate (DBP), diethyl phthalate (DEP), and dimethyl phthalate (DMP) under the simulated sunlight irradiation (lambda=320-680 nm) for the first time, and the conversion of DBP, DEP, and DMP reached to 98%, 84%, and 80%, respectively, after the simulated sunlight irradiation the suspension including PAE (5 mg L(-1), 100 mL) and PW(12)/TiO(2)-19.8 (100 mg) for 90 min. In addition, nearly total mineralization of DBP and DEP was realized by further increasing light irradiation time to 12h. Based on the intermediates identified in the reaction system, the photocatalytic degradation pathway of PAEs was put forward.
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Nanoestruturas , Ácidos Ftálicos/química , Ácidos Ftálicos/efeitos da radiação , Luz Solar , Titânio/química , Catálise , Fotoquímica , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta , Difração de Raios XRESUMO
Titania nanocomposite codoped with metallic silver and vanadium oxide was prepared by a one-step sol-gel-solvothermal method in the presence of a triblock copolymer surfactant (P123). The resulting Ag/V-TiO(2) three-component junction system exhibited an anatase/rutile (weight ratio of 73.8:26.2) mixed phase structure, narrower band gap (2.25 eV), and extremely small particle sizes (ca. 12 nm) with metallic Ag particles well distributed on the surface of the composite. The Ag/V-TiO(2) nanocomposite was used as the visible- and UV-light-driven photocatalyst to degrade dyes rhodamine B (RB) and coomassie brilliant blue G-250 (CBB) in an aqueous solution. At 1.8% Ag and 4.9% V doping, the Ag/V-TiO(2) system exhibited the highest visible- as well as UV-light photocatalytic activity; additionally, the activity of the three-component system exceeded that of Degussa P25, pure TiO(2), single-doped TiO(2) system (Ag/TiO(2) or V-TiO(2)) as well as P123-free-Ag/V-TiO(2) codoped system. The reasons for this enhanced photocatalytic activity were revealed.