Assuntos
Neurônios Dopaminérgicos/metabolismo , Epilepsias Mioclônicas/genética , Canal de Sódio Disparado por Voltagem NAV1.1/metabolismo , Transtornos Parkinsonianos/terapia , Adulto , Epilepsias Mioclônicas/complicações , Epilepsias Mioclônicas/diagnóstico , Síndromes Epilépticas/complicações , Síndromes Epilépticas/diagnóstico , Síndromes Epilépticas/metabolismo , Humanos , Masculino , Canal de Sódio Disparado por Voltagem NAV1.1/genética , Transtornos Parkinsonianos/complicações , Transtornos Parkinsonianos/diagnóstico , Espasmos Infantis/complicações , Espasmos Infantis/diagnóstico , Espasmos Infantis/metabolismoRESUMO
Little is known about the clinical aspects and medico-legal consequences of disrobing in the context of epileptic seizures. Seizure-related disrobing may occur either as an ictal automatism or during the postictal period. Some patients may experience a seizure while already in the unclothed state, engage in ictal wandering, and thereby appear in public in the nude. Two cases involving disrobing associated with seizures captured via video-monitored electroencephalography are offered. An additional case reveals the legal consequences endured by one patient who experienced a nocturnal seizure and began wandering in an unclothed state. Collectively, these cases illustrate the medical reality of seizure-related disrobing and the related adverse effects on patients' quality of life. Disrobing associated with epileptic seizures carries the potential for serious legal consequences if not properly identified as an ictal phenomenon.
Assuntos
Comportamento , Vestuário , Convulsões/psicologia , Adulto , Feminino , Humanos , Masculino , Estudos RetrospectivosRESUMO
Clinical studies from over half a century ago suggested efficacy of a variety of diuretics in focal and generalized epilepsies as well as in status epilepticus, but these findings have not been translated into modern epilepsy training or practice. Recent advances in our understanding of neuronal maturation and the pathophysiology of neonatal seizures provide fresh insight into the mechanisms by which diuretics might reduce susceptibility to seizures. In vitro and in vivo rodent studies and human epilepsy surgical cases have shown that specific diuretic agents targeting the cation-chloride cotransporters decrease neuronal synchrony and neuronal hyperexcitability. These agents are thought to convey their antiepileptic activity by either expanding the extracellular space or promoting a cellular chloride transport balance that reflects a more developmentally "mature," less excitable state. It may be time to reexamine whether diuretics could serve as adjunctive therapies in the treatment of refractory epilepsies.
Assuntos
Anticonvulsivantes/uso terapêutico , Diuréticos/uso terapêutico , Epilepsia/tratamento farmacológico , Sistemas de Transporte de Aminoácidos Básicos/metabolismo , Animais , Animais Recém-Nascidos , Anticonvulsivantes/farmacologia , Córtex Cerebral/efeitos dos fármacos , Córtex Cerebral/patologia , Cloretos/metabolismo , Diuréticos/farmacologia , Epilepsia/patologia , Humanos , Técnicas In Vitro , Recém-Nascido , Neurônios/efeitos dos fármacos , Neurônios/fisiologia , Ácido gama-Aminobutírico/metabolismoRESUMO
Counseling patients who suffer first-time or break- through seizures can be difficult, particularly when controllable external factors may be contributing to the lowering of their seizure threshold. High altitude as a potential trigger for seizures is a common question in our epilepsy clinics in Colorado, and this article reviews the existing anecdotal literature, presents our local experience with high altitude seizures (HAS), offers possible mechanisms to explain how high altitude may trigger seizures, and suggests an initial work-up and prophylactic strategies for future high altitude exposures.
Assuntos
Doença da Altitude/diagnóstico , Hipóxia/complicações , Convulsões/etiologia , Viagem , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Convulsões/terapia , Adulto JovemRESUMO
As increasing numbers of people live, work, and play at high altitudes, awareness of the neurological consequences of hypobaric hypoxic environments becomes paramount. Despite volumes of studies examining the pathophysiology of altitude sickness, the underlying mechanisms of the spectrum of altitude related illnesses is still elusive. High altitude headache, acute mountain sickness, high altitude cerebral edema and other neurological presentations including sleep disturbances and seizures at high altitude are reviewed. As our knowledge advances in the field of altitude physiology, the clinical and research techniques developed may help our understanding of hypoxic brain injury in general.
Assuntos
Doença da Altitude/complicações , Córtex Cerebral/patologia , Hipóxia Encefálica/complicações , Hipóxia Encefálica/etiologia , Doenças do Sistema Nervoso/etiologia , Doença da Altitude/epidemiologia , Doença da Altitude/genética , Doença da Altitude/terapia , Edema Encefálico/etiologia , Edema Encefálico/patologia , Transtornos Cognitivos/etiologia , Humanos , Hipóxia Encefálica/epidemiologia , Hipóxia Encefálica/genética , Transtornos dos Movimentos/etiologia , Transtornos dos Movimentos/terapia , Doenças do Sistema Nervoso/terapia , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/terapia , Transtornos da Visão/etiologiaRESUMO
Discontinuity in the silicone insulation over an electrode of a left vagus nerve stimulator (VNS) allowed the aberrant leak of current to the phrenic nerve and other structures. This resulted in ipsilateral diaphragmatic dysfunction, inability to vocalize, and severe radiating pain into the jaw and upper incisor for the duration of each stimulation. The device was explanted and a new device was implanted. All stimulation-related symptoms ceased immediately. A similar discontinuity in the silicone insulation is the likely explanation for several prior reports of poorly understood pains and phrenic nerve stimulation in patients with VNSs. The findings and analysis of this case establish a rationale for consideration of replacement of the VNS lead in all similarly symptomatic patients.