Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Int Immunopharmacol ; 93: 107341, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33486334

RESUMO

Although acute stress generally exerts positive effects on the immune system, chronic stress typically causes immunosuppression via the hypothalamic-pituitary-adrenal (HPA) axis. In this study, the effects of capsaicin (1.28 mg/kg intraperitoneally [i.p.] for 7 days) on immune parameters were evaluated under conditions of chronic stress. Capsaicin treatment significantly increased the immune response as evaluated by the delayed-type hypersensitivity (DTH) reaction to dinitrofluorobenzene (DNFB) and splenocyte proliferation assays- It also is able to rescue the splenocytes of the apoptosis induced by stress. The capsaicin treatment increased the production of Th1 cytokines and decreased the production of Th2 cytokines and TGF-ß1 in the plasma and culture supernatants of immunosuppressed mice, which is associated with the modulation of Th2 induced by stress cells. Moreover, the production of corticosterone significantly decreased in capsaicin-treated animals as compared to control groups. The capsaicin treatment further attenuated the immunosuppression induced by the corticosterone treatment (40 mg/kg i.p. for 7 days), albeit less potently, as exhibited in the DTH response. Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-ß1 through high doses of corticosterone, indicating direct cellular immunomodulation. These results show, that capsaicin is able to modulate chronic stress-induced immunosuppression, mediating corticosterone released inhibition, but also, that capsaicin significantly modulates the pharmacological action of corticosterone in vivo.


Assuntos
Capsaicina/farmacologia , Tolerância Imunológica/efeitos dos fármacos , Fatores Imunológicos/farmacologia , Estresse Fisiológico/efeitos dos fármacos , Animais , Proliferação de Células/efeitos dos fármacos , Corticosterona/farmacologia , Citocinas/sangue , Citocinas/imunologia , Dinitrofluorbenzeno , Hipersensibilidade Tardia/imunologia , Masculino , Camundongos Endogâmicos BALB C , Baço/citologia , Estresse Fisiológico/imunologia , Fator de Crescimento Transformador beta1/sangue , Fator de Crescimento Transformador beta1/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA