1.
Bioorg Med Chem Lett
; 18(15): 4393-6, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18614364
RESUMO
High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.