Orthodontic board certifications: Global perspectives, challenges, and evolving trends.

The Society of Orthodontic Specialty Certifying Boards aims to encourage the formation of new certifying orthodontic boards worldwide and stimulate existing orthodontic certifying boards to review and revise their certification process. The main goal of Society of Orthodontic Specialty Certifying Boards is to motivate more orthodontists to become board certified by demonstrating their skills through time to protect the public and the specialty from unqualified practitioners. This article identifies the existing barriers in board certification and suggests a scenario-based clinical examination.

Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal.

The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was explored for a very poorly water soluble antifungal active, itraconazole (ITR), which was, for the first time, successfully converted into this multicomponent solid using an aromatic coformer, terephthalic acid (TER). The new cocrystal was characterized in terms of its solid-state and structural properties, and a panel of pharmaceutical tests including wettability and dissolution were performed. Evidence of the cocrystal formation was obtained from liquid-assisted grinding, but not neat grinding. An efficient method of the ITR-TER cocrystal formation was ball milling. The stoichiometry of the ITR-TER phase was 2:1 and the structure was stabilized by H-bonds. When comparing ITR-TER with other cocrystals, the intrinsic dissolution rates and powder dissolution profiles correlated with the aqueous solubility of the coformers. The rank order of the dissolution rates of the active pharmaceutical ingredient (API) from the cocrystals was ITR-oxalic acid > ITR-succinic acid > ITR-TER. Additionally, the ITR-TER cocrystal was stable in aqueous conditions and did not transform to the parent drug. In summary, this work presents another cocrystal of ITR that might be of use in pharmaceutical formulations.

Impact of polyethylene glycol polymers on the physicochemical properties and mucoadhesivity of itraconazole nanoparticles.

Itraconazole (ITR) is a broad-spectrum antifungal drug with a very low solubility. In this work, the application of a heat induced evaporative antisolvent nanoprecipitation process yielded disordered nanoparticles (NPs) of ITR. The inclusion of different types of poly(ethylene glycol) (PEG) allowed PEGylation of NPs by adsorption to be achieved. The NP dispersions were composed of monodispersed particles in a nanometric size range (<290 nm) and although PEGylation had no impact on the average particle size, the surface potential was partially neutralised in the modified NPs. The solid state analysis using powder X-ray diffraction and thermal analysis revealed a disordered, liquid crystalline smectic organisation of the non-PEGylated NPs, while some of the PEGylated NPs were more crystalline. The PEGylated NPs exhibited mucoadhesive potential in stationary conditions (dynamic light scattering analysis) but when flow conditions were applied (nanoparticle tracking analysis and quartz crystal microbalance with dissipation) the particles had mucopenetrative properties. The non-PEGylated ITR NPs did not interact with mucin and therefore, this system was considered as having a mucopenetrative character. This study demonstrates that the properties of NPs made of organic drug molecules can be modified by the addition of polymers, which may impact on their interaction with mucin and therefore on their potential systemic absorption.

An interview with Sylvia Frazier-Bowers.

Dr. Frazier-Bowers is an associate professor at the University of North Carolina, Chapel Hill (UNC-CH), in the Department of Orthodontics. She received a BA from the University of Illinois, Urbana-Champaign, and a DDS from the University of Illinois, Chicago. After completing the NIH Dentist-Scientist Program at UNC-CH in Orthodontics (Certificate, 97') and Genetics and Molecular Biology (PhD, 99'), she completed a post-doctoral fellowship at the University of Texas Health Science Center, Houston (UTHSC), in the Department of Orthodontics. Leadership positions include president of local NC-AADR (North Carolina (2005-2006); director of the AADR Craniofacial Biology group (CBG) 2004-2007; IADR/AADR councilor for NC-AADR (2007, 2008, 2012) and for the CBG (2012-2015); member of Southern Association of Orthodontists Scientific Affairs Committee (2005-2013) and the American Association of Orthodontists Council on Scientific Affairs (2014 ­ Present). Dr. Frazier-Bowers also serves various editorial boards including the Journal of Dental Research and the Scientific Advisory board for the Consortium on Orthodontic Advances in Science and Technology. Her current role as faculty at UNC-CH includes conducting human genetic studies to determine the etiology of inherited tooth disorders, mentoring students at all levels, teaching graduate and pre-doctoral level Growth and Development courses and treating patients in the UNC School of Dentistry faculty practice in Orthodontics.