[Intensity of lipid peroxidation in the kidneys in nephrotoxic acute renal failure (experimental study)]. / Intensivnost' perikisnogo okisleniia lipidov v pochkakh pri nefrotoksicheskoi ostroi pochechnoi nedostatochnosti (eksperimental'noe issledovanie)

Mercury chloride was injected cubcutaneously in rats to induce nephrotoxic acute renal failure (ARF). Renal dysfunction in ARF occurs under intensification of lipid peroxidation in the kidneys. Pretreatment with antioxidant ionol diminishes lipid peroxidation intensity in the kidneys in ARF and restricts the severity of renal dysfunction.

[The rate of renal lipid peroxidation in myoglobinuric acute renal failure]. / Intensivnost' perekisnogo okisleniia lipidov v pochkakh pri miogemoglobinuricheskoi ostroi pochechnoi nedostatochnosti.

Rat experiments demonstrated that acute renal myoglobinuria was characterized by high renal lipid peroxidation rates. Prior administration of the antioxidant ionol reduced the activation of lipid peroxidation in renal tissue and diminished the severity of renal dysfunctions.

[Metabolism of proteins in the kidney during acute kidney failure]. / Obmen belkov v pochkakh pri ostroi pochechnoi nedostatochnosti.

Acute kidney insufficiency was simulated in rats by means of intramuscular administration of glycerol. Intensity of protein biosynthesis and content of proteins were increased, while their catabolism was decreased in kidney under these conditions. At the same time, half-life and a period of the proteins turnover were elongated, whereas the rate of their substitution was decreased.