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J Physiol Sci ; 63(1): 79-85, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22983821

RESUMO

The aim of the study was to determine the association between ACE I/D, ACTN3 R577X and PPARA intron 7 G/C gene polymorphisms and strength-related traits in 457 middle school-age children (219 boys and 238 girls; aged 11 ± 0.4 years). The assessment of different phenotypes was conducted with a number of performance tests. Gene polymorphisms were determined by PCR. The ACE D allele was associated with high results of standing long-jump test in boys [II 148.3 (16.3) cm, ID 152.6 (19.6) cm, DD 158.2 (19.1) cm; P = 0.037]. The ACTN3 R allele was associated with high results of performance tests in males only in combination with other genes (standing long-jump test: P = 0.021; handgrip strength test: P < 0.0001). Furthermore, the male carriers of the PPARA gene C allele demonstrated the best results of handgrip strength testing than GG homozygotes [GG 14.6 (4.0) kg, GC/CC 15.7 (4.3) kg; P = 0.048]. Thus, the ACE, ACTN3 and PPARA gene variants are associated with strength-related traits in physically active middle school-age boys.


Assuntos
Actinina/genética , Força Muscular/genética , PPAR alfa/genética , Peptidil Dipeptidase A/genética , Alelos , Índice de Massa Corporal , Peso Corporal/genética , Criança , Feminino , Força da Mão , Homozigoto , Humanos , Íntrons , Masculino , Fenótipo , Polimorfismo Genético , Esportes
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